The Anxiolytic-like Effects of Scutellaria baicalensis Using Elevated Plus-Maze in Rats

Korean Journal of Pharmacognosy

Volumn 35, Issue 1, 2004, Pages 22-27

  Jung, Ji Wook ^a   Ahn, Nam Yoon ^a   Park, Sung Hwan ^a   Oh, Jin Kyung ^a   Oh, Hye Rim ^a   Lee, Bo Kyung ^a   Om, Ae Son ^b   Kim, Beom Soo ^c   Kim, Dong Hyun ^a   Ryu, Jong Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Hanyang University   (South Korea)

^c Nature Co LTD   (South Korea)

Author keywords

Anxiety; Elevated Plus Maze; GABA; Scutellaria baicalensis; Serotonin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ANXIOLYTIC AGENT; FLUMAZENIL; PINDOLOL; SCUTELLARIA BAICALENSIS EXTRACT; SEROTONIN 1A ANTAGONIST;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG ISOLATION; LOCOMOTION; MAZE TEST; NONHUMAN; RAT; TRANQUILIZING ACTIVITY;

EID: 11144356669     PISSN: 02533073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sandford, J. J., Argyropoulos, S. V., and Nutt. D. J. (2000). The psychobiology of anxiolytic drugs. Part 1: Basic neruobiology. Pharmacol. Ther. 88: 197-212.
2. Argyropoulos, S. V., Sandford, J. J., and Nutt. D. J. (2000). The psychobiology of anxiolytic drug. Part 2: Pharmacological treatment of anxiety. Pharmacol. Ther. 88: 213-227.
3. Peng W.H., Hsieh M.T., Lee Y.S., Lin Y.C., and Liao J. (2000). Anxiolytic effect of seed of Zyziphus jujube in mouse of anxiety. J. Ethnopharmacol., 72(3): 435-441.
4. S. X. Wu, J. X. Zhang, T. Xu, L. F. Li, S. Y. Zhao, and M. Y. Lan. (1993). Effects of seeds, leaves and fruits of Ziziphus spinosa and jujuboside A on central nervous system function. China Journal of Chinese Materia Medica, 18: 685-687, 703-704.
5. Kim Y.H, Choi H.C, Sohn U.D, Lee K.Y, Kim W.J, Park H.B., and Ha J.H. (1996). Anxiolytic action of Gastrodia elata Blume. J. Korean Society of Biological Therapies in Psychiatry., 2(2): 108-114.
6. Takagi, S., Yamaki, M., and Imoto, K. (1980). Studies on the water-soluble constituents of roots of Scutellaria baicalensis, Yakugaku Zasshi, 100(12): 1220-1224.
7. Takino, Y., Miyahara, T., and Arichi, E. (1987). Determination of some flavonoids in Scutellariae radix by HPLC. Chem. Pharm. Bull., 35(8): 3494-3497.
8. Choi, K. J., Ko, S. R., and Yang, J. W. (1990). Identification of index components of Scutellariae Radix and quantitative determination of baicalin from crude drug preparation. Kor. J. Pharmacogn., 21(2): 158-162.
9. Handley, S. R. and Tricklebank, M. D. (1995). Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn Schmiedebergs Arch Pharmacol. 327: 1-5.
10. Pellow, S., Chopin, P., File, S. E., and Briley, M. (1985). Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14: 149-167.
11. Bonetti E. P., Pieri, L. Cumin, R., Schaffner, R., Pieri, M., Gamzu, E. R., Muller, R. K. M., and Haefely, W. (1982). Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects. Psychopharmacology (Berl). 78: 8-18.
12. Imaizumi M. and Onodera K. (2000). Animal models of anxiety. Nippon Yakurigaku Zasshi, 115(1): 5-12.
13. Kent, J. M., Mathew, S. J., and Gorman, J. M. (2002). Molecular Targets in the Treatment of Anxiety. Society of Biological Psychiatry. 52: 1008-1030.
14. Liao, J. F., Hung, W. Y., and Chen, C. F. (2003). Anxiolytic-like effects of baicalein and bacalin in the Vogel conflict test in mice. European Journal of Pharmacology, 464: 141-146.
15. Harvey, R. A., Champe, M. J., and Mycek, M. J. (2000). Lippincott's Illustrated Reviews Pharmacology, 2nd edition. Lippincott Williams Wilkins. 89-93, 119-126.