Component-based and whole-mixture techniques for addressing the toxicity of drinking-water disinfection by-product mixtures

Journal of Toxicology and Environmental Health - Part A

Volumn 67, Issue 8-10, 2004, Pages 741-754

  Simmons, Jane Ellen ^a,b   Teuschler, Linda K ^b   Gennings, Chris ^c   Speth, Thomas F ^d   Richardson, Susan D ^b   Miltner, Richard J ^d   Narotsky, Michael G ^a   Schenck, Kathleen D ^d   Hunter III, E Sidney ^a   Hertzberg, Richard C ^e   Rice, Glenn ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e Homeland Security Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMIDE; CHEMICAL AGENT; DRINKING WATER; IODIDE; ORGANIC MATTER; ORGANOHALOGEN DERIVATIVE;

CHLORINATION; CONFERENCE PAPER; DISINFECTION; HEALTH HAZARD; HUMAN; LIVER TOXICITY; MUTAGENICITY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PUBLIC HEALTH; REVERSE OSMOSIS; RISK ASSESSMENT; TOXICITY; WATER SUPPLY;

CHLORINE COMPOUNDS; DISINFECTANTS; HUMANS; RISK ASSESSMENT; WATER MICROBIOLOGY; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION; WATER SUPPLY;

EID: 11144354591     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390490428215     Document Type: Conference Paper

References (45)

1. Bove, F., Fulcomer, M., Klotz, J., Esmarat, J., Duffey, E. M. and Savrin, J. E. 1995. Public drinking water contamination and birth outcomes. Am. J. Epidemiol. 141:850-862.
2. Cantor, K. P., Lynch, C. F., Hildesheim, M. E., Dosemeci, M., Lubin, J., Alavanja, M., and Craun, G. 1998. Drinking water source and chlorination byproducts. I. Risk of bladder cancer. Epidemiology 9:21-28.
3. Centers for Disease Control and Prevention. 1999. Control of infectious diseases. Morbid. Mortal. Weekly Rep. 48(29):621-629.
4. DeAngelo, A. B., Geter, D. R., Rosenberg, D. W., Crary, C. K., and George, M. H. 2002. The induction of aberrant crypt foci (ACF) in the colons of rats by trihalomethanes administered in the drinking water. Cancer Lett. 187:25-31.
5. Dodds, L., and King W. D. 2001. Relation between trihalomethane compounds and birth defects. Occup. Environ. Med. 58:443-446.
6. Fair P. S. 1995. Influence of water quality on formation of chlorination by-products. In Drinking water: Critical issues in health effects research: Workshop report, pp. 14-17. Washington, DC: ILSI Press.
7. Gennings, C., Schwartz, P., Carter, H., and Simmons, J. E. 1997. An efficient approach for detecting departure from additivity in mixtures of many chemicals with a threshold additivity model. J. Agric. Biol. Environ. Stat. 2:198-211. Erratum, 2000, 5:257-259.
8. Hertzberg, R. C., and Teuschler, L. K. 2002. Evaluating quantitative formulas for dose-response assessment of chemical mixtures. Environ. Health Perspect. 110(suppl. 6):965-970.
9. Hildesheim, M. E., Cantor K. P., Lynch, C. F., Dosemeci, M. Lubin, J., Alavanja, M., and Craun, G. 1998. Drinking water source and chlorination byproducts. II. Risk of colon and rectal cancers. Epidemiology 9:29-35.
10. International Life Sciences Institute. 1998. Assessing toxicity of exposure to mixtures of disinfection byproducts: Research recommendations. Washington, DC: ILSI Risk Science Institute.
11. International Program on Chemical Safety. 2000a. Chemistry of disinfectants and disinfectant by-products. In Disinfectants and disinfectant by-products. Environmental health criteria 216, pp. 27-80. Geneva: World Health Organization.
12. International Program on Chemical Safety. 2000b. Toxicology of disinfectant by-products. In Disinfectants and disinfectant by-products. Environmental health criteria 216, pp. 110-276. Geneva: World Health Organization.
13. Keegan, T. E., Simmons, J. E., and Pegram, R. A. 1998. NOAEL and LOAEL determinations of acute hepatotoxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F-344 rats. J. Toxicol. Environ. Health 55:65-75.
14. King, W. D., and Marett, L. D. 1996. Case-control study of bladder cancer and chlorination byproducts in treated water (Ontario, Canada). Cancer Causes Control 7:596-604.
15. King, W. D., Dodds, L., and Allen, A. C. 2000. Relation between stillbirth and specific chlorination byproducts in public water supplies. Environ. Health Perspect. 108:883-886.
16. Krasner, S. W. 2001. Chemistry and occurrence of disinfection by-products. In Microbial pathogens and disinfection by-products in drinking water, eds. G. F. Craun, F. S. Hauchman, and D. E. Robinson, pp. 197-209. Washington, DC: ILSI Press.
17. Krasner, S. W., McGuire, M. J., Jacangelo, J. G., Patania, N. L., Reagan, K. M., and Aieta, E. M. 1989. The occurrence of disinfection byproducts in U.S. drinking water. J. Am. Water Works Assoc. 81:41-53.
18. Krasner, S. W., Pastor, S., Chinn, R., Sclimenti, M. J., Weinberg, H. S., Richardson, S. D., and Thruston, A. D., Jr. 2001. The occurrence of a new generation of DBPs (beyond the ICR). Proc. American Water Works Association Water Quality Technology Conference, 6-10 November, Nashville, TN. Denver, CO: American Water Works Association T8-01 (CD-ROM).
19. Lilly, P. D., Simmons, J. E., and Pegram, R. A. 1994. Dose-dependent vehicle differences in the acute toxicity of Bromodichloromethane. Fundam. Appl. Toxicol. 23:132-140.
20. Lilly, M. Z., Sey, Y. M., Seely, J. C., House, D. E., and Simmons, J. E. 2004 (accepted subject to revision). The influence of gavage vehicle and concurrent exposure to trichloroethylene on chloroform hepatic and renal toxicity. J. Toxicol. Environ. Health
21. Narotsky, M. G., Pegram, R. A., and Kavlock, R. J. 1997. Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride toxicity in rats. Fundam. Appl. Toxicol. 40:30-36.
22. National Cancer Institute. 1976. Report on the carcinogenesis bioassay of chloroform. NTIS PB-264-018. Bethesda, MD: National Cancer Institute.
23. National Toxicology Program. 1987. Toxicology and carcinogenesis studies of bromodichloromethane in F344/N rats and B6C3F1 mice (gavage studies). Tech. Rep. No. 321. NIH publication 88-2537. Research Triangle Park, NC:National Toxicology Program.
24. National Toxicology Program. 1989. Toxicology and carcinogenesis studies of bromoform in F344/N rats and B6C3F1 mice (gavage studies). Tech. Rep. No. 350. NIH. Research Triangle Park, NC:National Toxicology Program.
25. Richardson, S. D. 1998. Identification of drinking water disinfection byproducts. In Encyclopedia of environmental analysis and remediation, ed. R. A. Meyers, pp. 1398-1421. New York: John Wiley and Sons.
26. Richardson, S. D., Simmons, J. E., and Rice, G. 2002. DBPs: The next generation. Environ. Sci. Technol. 36:197A-205A.
27. Simmons, J. E., Teuschler, L. K., and Gennings, C. 2001. The toxicology of disinfection by-products: methods for multi-chemical assessment, present research efforts and future research needs. In Microbial pathogens and disinfection by-products in drinking water: Heath effects and management of risks, eds. G. F. Craun, F. S. Hauchman, and D. E. Robinson, pp. 325-340. Washington, DC: ILSI Press.
28. Simmons, J. E., Richardson, S. D., Speth, T. F., Miltner, R. J., Rice, G., Schenck, K. M., Hunter, S. E. III, and Teuschler, L. K. 2002. Development of a research strategy for integrated technology-based toxicological and chemical evaluation of complex mixtures of drinking water disinfection byproducts. Environ. Health Perspect. 110(suppl. 6):1013-1024.
29. Singer, P. C. 1995. Disinfection by-products: From source to tap. In Drinking water: Critical issues in health effects research: Workshop report, pp. 7-8. Washington, DC: ILSI Press.
30. Stevens, A. A., Moore, L. A., Slocum, C. J., Smith, B. L., Seeger, D. R., and Ireland, J. C. 1989. Disinfection by-products: Current perspectives. Denver, CO: American Water Works Association.
31. Teuschler, L. K., and Simmons, J. E. 2003. Approaching disinfection byproduct (DBP) toxicity as a mixtures problem. Am. Water Works Assoc. J. 95:131-138.
32. Teuschler, L. K., Gennings, C., Hartley, W. R., Stiller, W. M., Colman, J. T., Hertzberg, R. C., Thiyagarajah, A. Lipscomb, J. C., and Simmons, J. E. 2000. A multiple-purpose design approach to the evaluation of risks from mixtures of disinfection by-products. Drug Chem. Toxicol. 23:307-321.
33. Teuschler, L. K., Hertzberg, R. C., Rice, G. E., and Simmons, J. E. 2003 (in press). EPA project-level research strategies for chemical mixtures: Targeted research for meaningful results. Pharmacol. Toxicol.
34. U.S. Environmental Protection Agency. 1986. Guidelines for the Health Risk Assessment of Chemical Mixtures. Fed. Reg. 51(185):34014-34025.
35. U.S. Environmental Protection Agency. 1999. Research report on the risk assessment of mixtures of disinfection by-products (DBPs) in drinking water. EPA/600/R-03/039. Office of Research and Development/ National Center for Environmental Assessment. Cincinnati OH: U.S. Environmental Protection Agency.
36. U.S. Environmental Protection Agency. 2000a. Supplementary guidance for conducting health risk assessment of chemical mixtures. EPA/630/R-00/002. Washington, DC: U.S. Environmental Protection Agency.
37. U.S. Environmental Protection Agency. 2000b. Conducting a risk assessment for mixtures of disinfection by-products in drinking water treatment systems. EPA/600/R-03/040. Office of Research and Development/National Center for Environmental Assessment. Cincinnati OH: U.S. Environmental Protection Agency.
38. U.S. Environmental Protection Agency. 2003a. Integrated Risk Information System (IRIS). Bromoform. www.epa.gov/iris.
39. U.S. Environmental Protection Agency. 2003b. Integrated Risk Information System (IRIS). Chlorodibromomethane. www.epa.gov/iris.
40. U.S. Environmental Protection Agency. 2003c. Integrated Risk Information System (IRIS). Chloroform. www.epa.gov/iris.
41. U.S. Environmental Protection Agency. 2003d. Integrated Risk Information System (IRIS). Dichlorobromomethane. www.epa.gov/iris.
42. Waller, K., Swan, S. H., DeLorenze, G., and Hopkins, B. 1998. Trihalomethanes in drinking water and spontaneous abortion. Epidemiology. 9:134-140.
43. Waller, K., Swan, S. H., Windham, G. C., and Fenster, L. 2001. Influence of exposure assessment methods on risk estimates in an epidemiologic study of total trihalomethane exposure and spontaneous abortion. J. Expos. Anal. Environ. Epidemiol. 11:522-531.
44. Weinberg, H. S., Krasner, S. W., Richardson, S. D., and Thurston, S. D., Jr. 2002. The occurrence of disinfection by-products of health concern in drinking water: Results of a nationwide DBP occurrence study. National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, GA. EPA/600/ R-02/068. www.epa.gov/athens/publications/EPA_600-R02_068.pdf.
45. Woo, Y.-T., Lai, D., McLain, J. L., Manibusan, M. K., and Dellarco, V. 2002. Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products. Environ. Health Perspect. 110(suppl. 1):75-87.