Poor prognostic factors of hepatectomy in patients with resectable small hepatocellular carcinoma and cirrhosis

Journal of Cancer Research and Clinical Oncology

Volumn 130, Issue 4, 2004, Pages 197-202

  Ochiai, Toshia ^a   Sonoyama, Teruhisa ^a   Ichikawa, Daisuke ^a   Fujiwara, Hitoshi ^a   Okamoto, Kazuma ^a   Sakakura, Chohei ^a   Ueda, Yuji ^a   Otsuji, Eigo ^a   Itoi, Hirosumi ^a   Hagiwara, Akeo ^a   Yamagishi, Hisakazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Hepatectomy; Hepatocellular carcinoma; Liver transplantation; Risk factor

Indexed keywords

ALPHA FETOPROTEIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER PATIENT; CANCER SIZE; CONTROLLED STUDY; FEMALE; HEPATIC VEIN; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; METASTASIS; PORTAL VEIN; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; RISK FACTOR; SURVIVAL RATE; TREATMENT CONTRAINDICATION; TREATMENT INDICATION; TREATMENT OUTCOME;

AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATECTOMY; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 11144354457     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-003-0533-8     Document Type: Article

References (25)

1. Arii S, Yamaoka Y, Futagawa S, Inoue K, Kobayashi K, Kojiro M, Makuuchi M, Nakamura Y, Okita K, Yamada R (2000) Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinoma: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology 32:1224-1229
2. Bruix J, Llovet JM (2002) Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 35:519-524
3. Esnaola NF, Lauwers GY, Mirza NQ, Nagorney DM, Doherty D, Ikai I, Yamaoka Y, Regimbeau JM, Belghiti J, Curley SA, Ellis LM, Vauthey JN (2002) Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation. J Gastrointest Surg 6:224-232
4. Figueras J, Ibanez L, Ramos E, Jaurrieta E, Ortiz-de-Urbina J, Pardo F, Mir J, Loinaz C, Herrera L, Lopez-Cillero P, Santoyo J (2001) Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: results of a multicenter study. Liver Transpl 10:877-883
5. Gerunda GE, Neri D, Merenda R, Barbazza F, Zangrandi F, Meduri F, Bisello M, Valmasoni M, Gangemi A, Faccioli AM (2000) Role of transarterial chemoembolization before liver resection for hepatocarcinoma. Liver Transpl 6:619-626
6. Jonas S, Bechstein WO, Steinmuller T, Herrmann M, Radke C, Berg T, Settmacher U, Neuhaus P (2001) Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 33:1080-1086
7. Kaihara S, Kiuchi T, Ueda M, Oike F, Fujimoto Y, Ogawa K, Kozaki K, Tanaka K (2003) Living-donor liver transplantation for hepatocellular carcinoma. Transplantation 75:37-40
8. Liver Cancer Study Group of Japan (2000) The general rules for the clinical and pathological study of primary liver cancer (4th edn). Kanehara, Tokyo
9. Llovet JM, Fuster J, Bruix J (1999) Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection vs transplantation. Hepatology 39:1434-1440
10. Makuuchi M, Hasegawa H, Yamasaki S (1985) Ultrasonographically guided subsegmentectomy. Surg Gynecol Obstet 161:346-350
11. Margarit C, Charco R, Hidalgo E, Allende H, Castells L, Bilbao I (2002) Liver transplantation for malignant diseases: selection and pattern of recurrence. World J Surg 26:257-263
12. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334:693-699
13. Okano A, Hajiro K, Takakuwa H, Nishio A, Matsusue S, Sano A, Kobayashi Y (2000) Diffuse intrahepatic recurrence after resection of hepatocellular carcinoma. Hepatogastroenterology 47:1356-1359
14. Olthoff KM, Rosove MH, Shackleton CR, Imagawa DK, Farmer DG, Northcross P, Pakrasi AL, Martin P, Goldstein LI, Shaked A, Busuttil RW (1995) Adjuvant chemotherapy improves survival after liver transplantation for hepatocellular carcinoma. Ann Surg 221:734-743
15. Penn I (1991) Hepatic transplantation for primary and metastatic cancers of the liver. Surgery 110:726-735
16. Poon RT, Fan ST, Ng IO, Lo CM, Lin CL, Wong J (2000) Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 89:500-507
17. Poon RT, Fan ST, Lo CM, Liu CL, Wong J (2002) Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function. Ann Surg 235:373-382
18. Roayaie S, Frischer JS, Emre SH, Fishbein TM, Sheiner PA, Sung M, Miller CM, Schwartz ME (2002) Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Ann Surg 235:533-539
19. Salizzoni M, Romagnoli R, Lupo F, David E, Mirabella S, Cerutti E, Ottobrelli A (2003) Microscopic vascular invasion detected by anti-CD34 immunohistochemistry as a predictor of recurrence of hepatocellular carcinoma after liver transplantation. Transplantation 76:844-848
20. Shimada M, Hasegawa H, Gion T, Shirabe K, Taguchi K, Takenaka K, Tanaka S, Sugimachi K (1999) Risk factors of the recurrence of hepatocellular carcinoma originating from residual cancer cells after hepatectomy. Hepatogastroenterology 46:2469-2475
21. Stone MJ, Klintmalm GBG, Polter D, Husberg BS, Mennel RG, Ramsay MAE, Flemens EE, Goldstein RM (1993) Neoadjuvant chemotherapy and liver transplantation for hepatocellular carcinoma: a pilot study in 20 patients. Gastroenterology 104:196-202
22. Takata M, Yamanaka N, Tanaka T, Yamanaka J, Maeda S, Okamoto E, Yasojima H, Uematsu K, Watanabe H, Uragari Y (2000) What patients can survive disease-free after complete resection for hepatocellular carcinoma? A multivariate analysis. Jpn J Clin Oncol 30:75-81
23. Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hirohashi S, Ohashi Y, Kakizoe T (2000) Adoptive immunotherapy to lower post-surgical recurrence rates of hepatocellular carcinoma: a randomized trial. Lancet 356:802-807
24. Tamura S, Kato T, Berho M, Misiakos EP, O'Brien C, Reddy KR, Nery JR, Burke GW, Schiff ER, Miller J, Tzakis AG (2001) Impact of histological grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg 136:25-30
25. Yokoyama I, Todo S, Iwatsuki S, Starzl TE (1990) Role of liver transplantation in cancer therapy. Hepatogastroenterology 37:188-193