The role of a common TNNT2 polymorphism in cardiac hypertrophy

Journal of Human Genetics

Volumn 49, Issue 3, 2004, Pages 129-133

  Komamura, Kazuo ^a   Iwai, Naoharu ^a   Kokame, Koichi ^a   Yasumura, Yoshio ^a   Kim, Jiyoong ^a   Yamagishi, Masakazu ^a   Morisaki, Takayuki ^a   Kimura, Akinori ^b   Tomoike, Hitonobu ^a   Kitakaze, Masafumi ^a   Miyatake, Kunio ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cardiomyopathy; Genetics; Hypertrophy; Polymorphism; Troponin T

Indexed keywords

MESSENGER RNA; TROPONIN T;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; EXON; FEMALE; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HEIGHT; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; MULTIPLE REGRESSION; PATIENT SELECTION; POPULATION RESEARCH;

AGED; ALLELES; BASE SEQUENCE; DNA; FEMALE; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; INTRONS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PLASMIDS; POLYMORPHISM, GENETIC; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; TROPONIN T;

INSERTION SEQUENCES;

EID: 11144353640     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-003-0121-4     Document Type: Article

References (23)

1. Anderson PAW, Malouf NN, Oakeley AE, Pagani ED, Allen PD (1991) Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res 69:1226-1233
2. Anderson PA, Greig A, Mark TM, Malouf NN, Oakeley AE, Ungerleider RM, Allen PD, Kay BK (1995) Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart. Circ Res 76:681-686
3. Casale PN, Devereux RB, Kligfield P, Eisenberg RR, Miller DH, Chaudhary BS, Phillips MC (1985) Electrocardiographic detection of left ventricular hypertrophy: development and prospective validation of improved criteria. J Am Coll Cardiol 6:572-580
4. Coolidge CJ, Seely RJ, Patton JG (1997) Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucl Acids Res 225:888-896
5. Devereux RB, Reichek N (1977) Echocardiographic determination of left ventricular mass in men. Circulation 55:613-618
6. Devereux RB, Lutas EM, Cacale PN, Kligfield P, Eisenberg RR, Hammod IW, Miller DH, Reis G, Alderman MH, Laragh JH (1984) Standardization of M-mode echocardiographic left ventricular anatomic measurements. J Am Coll Cardiol 4:1222-1230
7. Farza H, Townsend PJ, Carrier L, Barton PJ, Mesnard L, Baehrend E, Forissier JF, Fiszman M, Yacoub MH, Schwartz K (1998) Genomic organization, alternative splicing and polymorphisms of the human cardiac troponin T gene. J Mol Cell Cardiol 30:1247-1253
8. Gardin JM, Henry WL, Savage DD, Ware JH, Burn C, Borer JS (1979) Echocardiographic measurements in normal subjects: evaluation of an adult population without clinically apparent heart disease. J Clin Ultrasound 7:439-447
9. Gomes AV, Guzman G, Zhao J, Potter JD (2002) Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J Biol Chem 277:35341-35349
10. Iwai N, Baba S, Mannami T, Katsuya T, Higaki J, Ogihara T, Ogata J (2001) Association of sodium channel γ-subunit promoter variant with blood pressure. Hypertension 38:86-89
11. Kannel WB, Gordon T, Castelli WP, Margolis JR (1972) Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease: the Framingham Study. Ann Intern Med 72:813-822
12. Krumholz HM, Larson M, Levy D (1995) Prognosis of left ventricular geometric pattern in the Framingham Heart Study. J Am Coll Cardiol 25:879-884
13. Kuroda YT, Komamura K, Tatsumi R, Mori K, Yoneda K, Katayama Y, Shigemoto S, Miyatake K, Hanafusa T (2001) Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension. Am J Hypertens 14:868-872
14. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP (1990) Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322:1561-1566
15. Luer MS, Anderson KM, Kannel WB, Levy D (1991) The impact of obesity on left ventricular mass and geometry. JAMA 266:231-236
16. Maron BJ (2002) Hypertrophic cardiomyopathy: a systemic review. JAMA 287:1308-1320
17. Mesnard L, Logeart D, Taviaux S, Dirlong S, Mercadier JJ, Samson F (1995) Human cardiac troponin T: cloning and expression of new isoforms in the normal and failing heart. Circ Res 76:687-692
18. Mesnard-Rouiller L, Mercadier JJ, Butler-Browne G, Heimburger M, Logeart D, Allen PD, Samson F (1997) Troponin T mRNA and protein isoforms in the human left ventricle: pattern of expression in failing and control hearts. J Mol Cell Cardiol 29:3043-3055
19. Norton PA (1994) Polypyrimidine tract sequences direct selection of alternative branch sites and influence protein binding. Nucl Acids Res 22:3854-3860
20. Romhilt DW, Estes EH (1968) A point-score system for the ECG diagnosis of left ventricular hypertrophy. Am Heart J 75:752-758
21. Roscigno RF, Weiner M, Garcia-Blanco M (1993) A mutational analysis of the polypyrimidine tract of introns: effects of sequence differences in pyrimidine tracts on splicing. J Biol Chem 268:11222-11229
22. Saba Z, Nassar R, Ungerleider RM, Oakeley AE, Anderson PA (1996) Cardiac troponin T isoform expression correlates with pathophysiological descriptors in patients who underwent corrective surgery for congenital heart disease. Circulation 94:472-476
23. Torrealba JR, Lozano E, Griffin M, Stoker S, McDonald K, Greaser M, Wolff MR (2002) Maximal ATPase activity and calcium sensitivity of reconstituted myofilaments are unaltered by the fetal troponin T re-expressed during human heart failure. J Mol Cell Cardiol 34:797-805