A phase III randomised study comparing two different dose-intensity regimens as induction chemotherapy followed by thoracic irradiation in patients with advanced locoregional non-small-cell lung cancer

Annals of Oncology

Volumn 15, Issue 3, 2004, Pages 399-409

  Sculier, J P ^a   Lafitte, J J ^c   Berghmans, T ^a   Van Houtte, P ^a   Lecomte, J ^d   Thiriaux, J ^d   Efremidis, A ^e   Koumakis, G ^e   Giner, V ^f   Richez, M ^g   Corhay, J L ^h   Wackenier, P ⁱ   Lothaire, P ^a   Paesmans, M ^a   Mommen, P ^a   Ninane, V ^b  

^a JULES BORDET INSTITUTE   (Belgium)

^b SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d Centre Hospitalier Universitaire de Charleroi   (Belgium)

^e Hellenic Anti cancer Institute   (Greece)

^f HOSPITAL DE SAGUNTO   (Spain)

^g CHR Saint Joseph Warquignies   (Belgium)

^h CH Peltzer La Tourelle   (Belgium)

ⁱ Centre Hospitalier Universitaire Ambroise Pare   (Belgium)

Author keywords

Chemotherapy; Non small cell lung cancer; Radiotherapy; Stage III

Indexed keywords

CARBOPLATIN; CISPLATIN; IFOSFAMIDE; MESNA; MITOMYCIN C;

ADULT; AGED; ALOPECIA; ARTICLE; BLEEDING; CANCER MORTALITY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG WITHDRAWAL; FEMALE; HEARING LOSS; HEART DISEASE; HEMATOLOGIC DISEASE; HISTOPATHOLOGY; HUMAN; INFECTION; INTERMETHOD COMPARISON; KIDNEY DISEASE; LEUKOPENIA; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROLOGIC DISEASE; PHASE 3 CLINICAL TRIAL; PLEURA EFFUSION; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SKIN DISEASE; STOMATITIS; THROMBOCYTOPENIA; TREATMENT OUTCOME; URINARY TRACT DISEASE;

EID: 11144353616     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdh105     Document Type: Article

References (40)

1. Mattson K, Holsti LR, Holsti P et al. Inoperable non-small cell lung cancer: Radiation with or without chemotherapy. Eur J Cancer Clin Oncol 1988; 24: 477-482.
2. Dillman RO, Seagren SL, Propert KJ et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med 1990; 323: 940-945.
3. Dillman RO, Seagren SL, Propert KJ et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med 1990; 323: 940-945.
4. Dillman RO, Herndon J, Seagren SL et al. Improved survival in stage III non-small-cell lung cancer: Seven-year follow-up of Cancer and Leukemia Group B (CALGB) 8433 trial. J Natl Cancer Inst 1996; 88: 1210-1215.
5. Le Chevalier T, Arriagada R, Quoix E et al. Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: First analysis of a randomized trial in 353 patients. J Natl Cancer Inst 1991; 83: 417-423.
6. Arriagada R, Le Chevalier T, Pignon JP et al. Initial chemotherapeutic doses and survival in patients with limited small-cell lung cancer. N Engl J Med 1993; 329: 1848-1852.
7. Sause WT, Scott C, Taylor S et al. Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J Natl Cancer Inst 1995; 87: 198-205.
8. Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 1995; 311: 899-909.
9. Sculier JP, Berghmans T, Paesmans M et al. The role of chemotherapy in the treatment of non-metastatic, non-small cell bronchial cancers. Rev Med Brux 2001; 22:477-487.
10. Marino P, Preatoni A, Cantoni A. Randomized trials of radiotherapy alone versus combined chemotherapy and radiotherapy in stages IIIa and IIIb nonsmall cell lung cancer. A meta-analysis. Cancer 1995; 76: 593-601.
11. Pritchard RS, Anthony SP. Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced, unresectable, non-small-cell lung cancer. A meta-analysis (published erratum appears in Ann Intern Med 1997; 126: 670). Ann Intern Med 1996; 125: 723-729.
12. Donnadieu N, Paesmans M, Sculier JP. Chimiothérapie des cancers bronchiques non à petites cellules. Méta-analyse de la littérature en fonction de l'extension de la maladie. Rev Mal Respir 1991; 8: 197-204.
13. Gralla RJ, Casper ES, Kelsen DP et al. Cisplatin and vindesine combination chemotherapy for advanced carcinoma of the lung: A randomized trial investigating two dosage schedules. Ann Intern Med 1981; 95: 414-420.
14. Klastersky J, Sculier JP, Ravez P et al. A randomized study comparing a high and a standard dose of cisplatin in combination with etoposide in the treatment of advanced non-small-cell lung carcinoma. J Clin Oncol 1986; 4: 1780-1786.
15. Shinkai T, Saijo N, Eguchi K et al. Cisplatin and vindesine combination chemotherapy for non-small cell lung cancer. a randomized trial comparing two dosages of cisplatin. Jpn J Cancer Res 1986; 77: 782-789.
16. Gandara DR, Crowley J, Livingston RB et al. Evaluation of cisplatin intensity in metastatic non-small-cell lung cancer: A phase III study of the Southwest Oncology Group. J Clin Oncol 1993; 11: 873-878.
17. Rinaldi M, Crino L, Scagliotti GV et al. A three-week schedule of gemcitabine-cisplatin in advanced non-small-cell lung cancer with two different cisplatin dose levels: A phase II randomized trial. Ann Oncol 2000; 11: 1295-1300.
18. Sculier JP, Klastersky J, Giner V et al. Phase II randomized trial comparing high-dose cisplatin with moderate-dose cisplatin and carboplatin in patients with advanced non-small-cell lung cancer. European Lung Cancer Working Party. J Clin Oncol 1994; 12: 353-359.
19. Sculier JP, Paesmans M, Thiriaux J et al. Phase III randomized trial comparing cisplatin and carboplatin with or without ifosfamide in patients with advanced non-small-cell lung cancer. European Lung Cancer Working Party. J Clin Oncol 1998; 16: 1388-1396.
20. Sculier JP, Lafitte A Paesmans M et al. Phase III randomized trial comparing moderate-dose cisplatin to combined cisplatin and carboplatin in addition to mitomycin and ifosfamide in patients with stage IV non-small-cell lung cancer, Br J Cancer 2000; 83: 1128-1135.
21. Sculier JP, Lafitte JJ, Lecomte J et al. A three-arm phase III randomised trial comparing combinations of platinum derivatives, ifosfamide and/or gemcitabine in stage IV non-small-cell lung cancer. Ann Oncol 2002; 13: 874-882.
22. Freedman LS, White SJ. On the use of Pocock and Simon's method for balancing treatment numbers over prognostic factors in the controlled clinical trial. Biometrics 1976; 32: 691-694.
23. Sculier JP, Paesmans M, Lafitte JJ et al. A randomised phase III trial comparing consolidation treatment with further chemotherapy to chest irradiation in patients with initially unresectable locoregional. non-small-cell lung cancer responding to induction chemotherapy. European Lung Cancer Working Party. Ann Oncol 1999; 10: 295-303.
24. Sculier JP, Paesmans M, Bureau G et al. Randomized trial comparing induction chemotherapy versus induction chemotherapy followed by maintenance chemotherapy in small-cell lung cancer. European Lung Cancer Working Party. J Clin Oncol 1996; 14: 2337-2344.
25. Cullen MH, Billingham LJ, Woodroffe CM et al. Mitomycin, ifosfamide, and cisplatin in unresectable non-small-cell lung cancer: effects on survival and quality of life. J Clin Oncol 1999; 17: 3188-3194.
26. Sculier JP, Paesmans M, Thiriaux J et al. A comparison of methods of calculation for estimating carboplatin AUC with a retrospective pharmacokinetic-pharmacodynamic analysis in patients with advanced non-small cell lung cancer. European Lung Cancer Working Party. Eur J Cancer 1999; 35: 1314-1319.
27. Erkisi M, Doran F, Burgut R, Kocabas A. A randomised trial of two cisplatin-containing chemotherapy regimens in patients with stage III-B and IV non-small cell lung cancer. Lung Cancer 1995; 12: 237-246.
28. Dillman RO, Seagren SL, Propert KJ et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone instage III non-small-cell lung cancer. N Engl J Med 1990; 323: 940-945.
29. Le Chevalier T, Arriagada R, Quoix E et al. Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: First analysis of a randomized trial in 353 patients. J Natl Cancer Inst 1991; 83: 417-423.
30. Crino L, Latini P, Meacci M et al. Induction chemotherapy plus high-dose radiotherapy versus radiotherapy alone in locally advanced unresectable non-small-cell lung cancer. Ann Oncol 1993; 4: 847-851.
31. Gregor A, Macbeth FR, Paul J et al. Radical radiotherapy and chemotherapy in localized inoperable non-small-cell lung cancer: A randomized trial. J Natl Cancer Inst 1993; 85: 997-999.
32. Wolf M, Hans K, Becker H et al. Radiotherapy alone versus chemotherapy with ifosfamide/vindesine followed by radiotherapy in unresectable locally advanced non-small cell lung cancer. Semin Oncol 1994; 21 (3 Suppl 4): 42-47.
33. Planting A, Helle P, Drings P et al. A randomized study of high-dose split course radiotherapy preceded by high-dose chemotherapy versus high-dose radiotherapy only in locally advanced non-small-cell lung cancer. An EORTC Lung Cancer Cooperative Group trial. Ann Oncol 1996; 7: 139-144.
34. Brodin O, Nou E, Mercke C et al. Comparison of induction chemotherapy before radiotherapy with radiotherapy only in patients with locally advanced squamous cell carcinoma of the lung. The Swedish Lung Cancer Study Group. Eur J Cancer 1996; 32A: 1893-1900.
35. Johnstone DW, Byhardt RW, Ettinger D, Scott CB. Phase III study comparing chemotherapy and radiotherapy with preoperative chemotherapy and surgical resection in patients with non-small-cell lung cancer with spread to mediastinal lymph nodes (N2); final report of RTOG 89-01. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 2002; 54: 365-369.
36. Furuse K, Fukuoka M, Kawahara M et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol 1999; 17: 2692.
37. Grunenwald D, Le Chevalier T. Re: Stage IIIA category of non-small-cell lung cancer: A new proposal (published erratum appears in J Natl Cancer Inst 1997; 89: 328). J Natl Cancer Inst 1997; 89: 88-89.
38. Mountain CF. A new international staging system for lung cancer. Chest 1986; 89 (4 Suppl): 225S-233S.
39. Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest 1997; 111: 1710-1717.
40. Sculier JP, Paesmans M, Lafitte JJ et al. Prognostic factors analysis for response to chemotherapy and survival in a prospective cohort of patients with unresectable, locoregional non small cell lung cancer initially treated by induction chemotherapy. Rev Oncologia 1999; 1: 92-100.