Pure red-cell aplasia caused by the antibody to recombinant erythropoietin, epoetin-β, in a Japanese patient with chronic renal failure

American Journal of Hematology

Volumn 78, Issue 1, 2005, Pages 15-20

  Shinohara, Kenji ^a   Mitani, Noriyuki ^a   Miyazaki, Mutsuko ^a   Sakuragi, Shizu ^a   Matsuda, Kazuyuki ^a   Ogawara, Satoru ^b   Saito, Takao ^b   Kaneoka, Hidetoshi ^b   Ooji, Toshiharu ^c  

^a Yamaguchi Pref Central Hospital   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c Nagato General Hospital   (Japan)

Author keywords

Antibody; EPO; Erythropoietin; PRCA; Pure red cell aplasia

Indexed keywords

ANTIBODY; CYCLOSPORIN; ERYTHROPOIETIN ANTIBODY; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG;

AGED; ANEMIA; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CHRONIC KIDNEY FAILURE; CROSS REACTION; ERYTHROCYTE TRANSFUSION; HEMODIALYSIS; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PURE RED CELL ANEMIA;

AGED; ANEMIA; ANTIBODIES; ASIAN CONTINENTAL ANCESTRY GROUP; CROSS REACTIONS; ERYTHROPOIETIN, RECOMBINANT; HUMANS; IMMUNOPRECIPITATION; KIDNEY FAILURE, CHRONIC; MALE; RED-CELL APLASIA, PURE;

EID: 11144332960     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20245     Document Type: Article

References (14)

1. Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and anti-erythropoietin antibodies in patients with recombinant erythropoietin. N Engl J Med 2002;346:469-475.
2. Gershon SK, Lukesenburg H, Cote TR, Braun MM. Pure red-cell aplasia and recombinant erythropoietin. N Engl J Med 2002;346:1584-1585.
3. Shimane M, Motojima H, Fukushima M. Development of assay methods for anti-recombinant human erythropoietin antibodies. J Clin Ther Med 1990;6:33-50 (in Japanese with English abstract).
4. Matsubara K, Yoshimura T, Kamachi S, Fukushima M, Hino M, Morii H. Radioimmunoassay for erythropoietin using anti-recombinant erythropoietin antibody with high affinity. Clin Chim Acta 1989;185:177-184.
5. Miyazaki Y, Kuriyama K, Higuchi M, et al. Establishment and characterization of a new erythropoietin-dependent acute myeloid leukemia cell lines, AS-E2. Leukemia 1997;11:1941-1949.
6. Imai N, Higuchi M, Kawamura A. et al. Physicochemical and biological characterization of asialoerythropoietin. Suppressive effects of sialic acid in the expression of biological activity of human erythropoietin in vitro. Eur J Biochem 1990;194:457-462.
7. Higuchi M, Oh-eda M, Kuboniwa H, Tomonoh K, Shimonaka Y, Ochi N. Role of sugar chains in the expression of the biological activity of human erythropoietin. J Biol Chem 1992;267:7703-7709.
8. Tacey R, Greway A, Smiell J, et al. The detection of anti-erythropoietin antibodies in human serum and plasma. Part I. Validation of the protocol for a radioimmunoprecipitation assay. J Immunol Methods 2003;283:317-329.
9. Bergrem H, Danielson BG, Eckardt K-U, Kurtz A, Stridsberg M. A case of antierythropoietin antibodies following recombinant human erythropoietin treatment. In: Bauer C, Koch KM, Scigalla P, Wieczorek L, editors. Erythropoietin: molecular physiology and clinical application. New York: Marcel Dekker; 1993. p 266-275.
10. Rossert J (editor). PRCA communiqué: a global perspective. North Wales, PA: Nexus Communications, Inc.: 2003. Vol 1, issue 2, p 1-15.
11. Locatelli F, Aljama P, Barany P, et al. Erythropoiesis-stimulating agents and antibody-mediated pure red cell aplasia: where are we now and where do we go from here? Nephrol Dial Transplant 2004;19:288-293.
12. Macdougall IC. Pure red cell aplasia with anti-erythropoietin antibodies occurs more commonly with one formulation of epoetin alfa than another. Curr Med Res Opin 2004;20:83-86.
13. Bunn HF. Drug-induced autoimmune red-cell aplasia. N Engl J Med 2002;346:522-523.
14. Verhelst D, Rossert J, Casadevall N, MacDougall IC, Kruger A, Eckardt K-U. Treatment of antibody-mediated pure red cell aplasia. J Am Soc Nephrol 2003;14:27A.