Cisplatin/etoposide chemotherapy combined with twice daily thoracic radiotherapy for limited small-cell lung cancer: A clinical Phase II trial

International Journal of Radiation Oncology Biology Physics

Volumn 61, Issue 1, 2005, Pages 70-75

  Chen, Gui Yuan ^a   Jiang, Guo Liang ^a,b   Wang, Li Juan ^a   Qian, Hao ^a   Fu, Xiao Long ^a   Yang, Huajun ^a   Wu, Kai Liang ^a   Zhao, Sen ^a  

^a FUDAN UNIVERSITY   (China)

^b PR ^*  (China)

Author keywords

Chemotherapy; Clinical trial; Hyperfractionated accelerated radiation therapy; Limited stage small cell lung cancer

Indexed keywords

COMPUTERIZED TOMOGRAPHY; FAILURE ANALYSIS; PATIENT MONITORING; PULMONARY DISEASES; RADIATION; RADIOTHERAPY; TUMORS;

ETOPSIDE (EP); HYPERFRACTIONATED ACCELERATED RADIATION THERAPY (HART); LIMITED-STAGE SMALL-CELL LUNG CANCER (LSCLC);

CHEMOTHERAPY;

CISPLATIN; CORTICOSTEROID; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ESOPHAGITIS; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; LEUKOPENIA; LUNG FIBROSIS; LUNG SMALL CELL CANCER; LUNG TOXICITY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIATION INJURY; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CARCINOMA, SMALL CELL; CISPLATIN; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; ETOPOSIDE; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; RADIOTHERAPY; RADIOTHERAPY DOSAGE;

EID: 11144319428     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.04.058     Document Type: Article

References (14)

1. Ihde D.C., Pass H.I., Glatstein E. Cancer of the lung. DeVita V.T., Hellman S., Rosenberg S.A. Cancer principles & practice of oncology. 1997;849-949 Lippincott-Raven, Philadelphia
2. Pignon J.P., Arriagada R., Ihde D.C., et al. A meta-analysis of thoracic radiotherapy for small cell lung cancer. N Engl J Med. 327:1992;1618-1624
3. Warde P., Payne D. Does thoracic irradiation improve survival and local control in limited stage small cell carcinoma of the lung? A meta-analysis. J Clin Oncol. 10:1992;890-895
4. Turrisi A.T., Kyungmann K., Blum R., et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med. 340:1999;265-271
5. Cox J.D., Stetz J., Pajak T.F. Toxicity criteria of RTOG and EORTC. Int J Radiat Oncol Biol Phys. 31:1995;1341-1346
6. Rubin P., Constine L.S., Fajardo L.F., et al. Late effect of normal tissues (LENT) consensus conference. Int J Radiat Oncol Biol Phys. 31:1995;1049-1091
7. Fukuoka M., Furuse K., Saijo N., et al. Randomized trial of cyclophosphamide, doxorubicin, and vincristine versus cisplatin and etoposide versus alternation of these regimens in small cell lung cancer. J Natl Cancer Inst. 83:1991;855-861
8. Sandler A.B. Current management of small cell lung cancer. Semin Oncol. 24:1997;462-476
9. Withers H.R. Treatment induced accelerated human tumor growth. Semin Radiat Oncol. 3:1993;135-144
10. Perry M., Eaton W.C., Propert K.J., et al. Chemotherapy with or without radiation therapy in limited small cell lung cancer. N Engl J Med. 316:1987;912-918
11. Work E, Nielsen O, Bentzen, SM, et al. Randomized trial of initial versus late chest irradiation with chemotherapy in limited small cell lung cancer. J Clin Oncol 1997;15:3030-3037
12. Ihde D.C., Glatstein E., Pass H.I. Small cell lung cancer. DeVita V.T., Hellman S., Rosenberg S.A. Cancer principles & practice of oncology. 5th ed:1997;911-950 Lippincott-Raven, Philadelphia
13. Takada M., Fukuoka M., Kawahara M., et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small cell lung cancer Results of the Japan Clinical Oncology Group Study 9104. J Clin Oncol. 20:2003;3054-3060
14. The Prophylactic Cranial Irradiation Overview Collaborative Group. Cranial irradiation for preventing brain metastases of small cell lung cancer in patients in complete remission. Cochrane Database of Syst Rev (4):CD002805, 2000