Highly efficient synthesis of 2′,3′-didehydro-2′, 3′-dideoxy-β-nucleosides through a sulfur-mediated reductive 2′,3′-trans-elimination. From iodomethylcyclopropanes to thiirane analogs

Tetrahedron Letters

Volumn 46, Issue 3, 2005, Pages 469-473

  De Cienfuegos, Luis Álvarez ^a   Mota, Antonio J ^a   Rodríguez, Concepción ^a   Robles, Rafael ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

d4T; Nucleosides; Reductive elimination; Semiempirical calculations; Thiirane

Indexed keywords

2 ALLYL MALONIC ACID DIETHYL ESTER; 2 IODOMETHYLCYCLOPROPANE 1,1 DICARBOXYLIC ACID DIETHYL ESTER; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ALKANE DERIVATIVE; CYCLOPROPANE DERIVATIVE; ESTER DERIVATIVE; IODINE DERIVATIVE; MALONIC ACID DERIVATIVE; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; GEOMETRY; METHODOLOGY; REACTION ANALYSIS; REDUCTION; STRUCTURE ANALYSIS;

EID: 11144315468     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.11.087     Document Type: Article

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