Mendelian inheritance of polygenic diseases: A hypothetical basis for increasing incidence

Medical Hypotheses

Volumn 64, Issue 3, 2005, Pages 495-498

  Awdeh, Z L ^a   Alper, Chester A ^a,b  

^a CENTER FOR BLOOD RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASTHMA; CELIAC DISEASE; DOMINANT INHERITANCE; ENVIRONMENTAL FACTOR; GENE FREQUENCY; GENE LOCUS; GENETIC DISORDER; GENETIC DRIFT; GENETIC RISK; GENETIC SELECTION; GENETIC SUSCEPTIBILITY; HUMAN; HYPOTHESIS; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; MATHEMATICAL ANALYSIS; MORBIDITY; MORTALITY; MULTIFACTORIAL INHERITANCE; PARENT; POPULATION GENETICS; PRIORITY JOURNAL; PROGENY; RECESSIVE INHERITANCE;

ALLELES; DISEASE SUSCEPTIBILITY; GENETIC DISEASES, INBORN; HUMANS; INCIDENCE; MODELS, GENETIC; MODELS, THEORETICAL; MULTIFACTORIAL INHERITANCE; SELECTION (GENETICS);

EID: 11144313061     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.08.025     Document Type: Article

References (8)

1. G. Thomson A two locus model for juvenile diabetes Ann Hum Genet 43 1980 383 398
2. C.A. Alper, D.P. Dubey, and Z. Awdeh A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease Exp Clin Immunogenet 17 2000 138 147
3. L.L. Cavalli-Sforza, and W.F. Bodmer D. Kennedy R.B. Park The genetics of human populations 1971 WH Freeman and Company San Francisco, CA 58
4. M. Richards, H. Côrte-Real, and P. Forster Paleolithic and neolithic lineages in the european mitochondrial gene pool Am J Hum Genet 59 1996 185 203
5. T.R. Myers Pediatric asthma epidemiology: incidence, morbidity, and mortality Respir Care Clin N Am 6 2000 1 14
6. G.R. Corazza, and G. Gasbarrini Coeliac disease in adults Bailliere Clin Gastr 9 1995 329 350
7. E.A. Gale The rise of childhood type 1 diabetes in the 20th century Diabetes 51 2002 3353 3361
8. K. Campbell Danger ahead: the emerging epidemic of type 2 diabetes in children J Am Pharm Assoc 43 2003 533 534