Engineering lanthanide complexes with controlled water exchange rates for magnetic resonance imaging

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volumn 26 VII, Issue , 2004, Pages 5254-5257

  Woods, Mark ^a,b   Sherry, A Dean ^b,c  

^a Macrocyclics   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Lanthanides; MRI contrast agents; Water exchange rates

Indexed keywords

COMPLEXATION; COORDINATION REACTIONS; DISSOCIATION; LANTHANUM COMPOUNDS; MOLECULAR DYNAMICS; RELAXATION PROCESSES; WEAR OF MATERIALS;

CONTROLLED WATER EXCHANGE; LANTHANIDE COMPLEXES; MRI CONTRAST AGENTS; OPTIMAL WATER RESIDENCE LIFETIME; WATER EXCHANGE RATES;

MAGNETIC RESONANCE IMAGING;

EID: 11144304106     PISSN: 05891019     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (9)

1. P. Caravan, J. J. Ellison, T. J. McMurry, and R. B. Lauffer, "Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications," Chem.l Rev., vol. 99, pp. 2293-2352, 1999.
2. III complexes with fast water exchange and high thermodynamic stability: potential building blocks for high-relaxivity MRI contrast agents," Chem. Eur. J., vol. 9, pp. 3555-3566, 2003.
3. S. Hoeft and K. Roth, "Structure and dynamics of lanthanoid tetraazacyclododecanetetraacetate DOTA complexes in solution," Chem. Ber., vol. 126, pp. 869-73, 1993.
4. M. Woods, S. Aime, M. Botta, J. A. K. Howard, J. M. Moloney, M. Navet, D. Parker, M. Port, and O. Rousseaux, "Correlation of Water Exchange Rate with Isomeric Composition in Diastereoisomeric Gadolinium Complexes of Tetra(carboxyethyl)dota and Related Macrocyclic Ligands," J. Am. Chem. Soc., vol. 122, pp. 9781-9792, 2000.
5. M. Woods, Z. Kovacs, S. Zhang, and A. D. Sherry, "Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes," Angew. Chem. Int'l. Ed, vol. 42, pp. 5889-5892, 2003.
6. M. Woods, Z. Kovacs, R. Kiraly, E. Brucher, S. Zhang, and A. D. Sherry, "Solution Dynamics and Stability of Lanthanide(III) (S)-2-(p-Nitrobenzyl)DOTA Complexes," Inorg. Chem., vol. 43, pp. 2845-2851, 2004.
7. S. Zhang, M. Merritt, D. E. Woessner, R. E. Lenkinski, and A. D. Sherry, "PARACEST Agents: Modulating MRI Contrast via Water Proton Exchange," Acc. Chem. Res., vol. 36, pp. 783-790, 2003.
8. M. Woods, S. Zhang, and A. D. Sherry, "Toward the Design of MR Agents for Imaging β-cell Function," Curr. Med Chem., pp. In press, 2004.
9. S. Aime, A. Barge, A. S. Batsanov, M. Botta, D. D. Castelli, F. Fedeli, A. Mortillaro, D. Parker, and H. Puschmann, "Controlling the variation of axial water exchange rates in macrocyclic lanthanide(III) complexes," Chem. Commun., pp. 1120-1121, 2002.