Nested stromal epithelial tumor of the liver: Six cases of a distinctive pediatric neoplasm with frequent calcifications and association with Cushing syndrome

American Journal of Surgical Pathology

Volumn 29, Issue 1, 2005, Pages 10-20

  Heerema McKenney, Amy ^a,e   Leuschner, Ivo ^b   Smith, Nicholas ^c   Sennesh, Joel ^d   Finegold, Milton J ^a  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF KIEL   (Germany)

^c PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^d INOVA FAIRFAX HOSPITAL   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

CD56; Liver tumor; Ossifying stromal epithelial tumor; Pediatric; WT 1

Indexed keywords

ALPHA ACTIN; ALPHA FETOPROTEIN; ANDROSTENEDIONE; CARCINOEMBRYONIC ANTIGEN; CD34 ANTIGEN; CD56 ANTIGEN; CD99 ANTIGEN; CHROMOGRANIN A; CORTICOTROPIN; CYTOKERATIN 19; CYTOKERATIN 4; CYTOKERATIN 7; DESMIN; EPITHELIAL MEMBRANE ANTIGEN; ESTROGEN RECEPTOR; HYDROCORTISONE; INHIBIN; KI 67 ANTIGEN; NEURON SPECIFIC ENOLASE; PRASTERONE; PROGESTERONE; PROGESTERONE RECEPTOR; PROTEIN S 100; SMOOTH MUSCLE ACTIN; STEM CELL FACTOR RECEPTOR; SYNAPTOPHYSIN; TESTOSTERONE; UNCLASSIFIED DRUG; VIMENTIN; WT1 PROTEIN;

ADOLESCENT; ARTICLE; CALCIFICATION; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CUSHING SYNDROME; EPITHELIUM TUMOR; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LAPAROTOMY; LIVER RESECTION; LIVER TUMOR; MALE; MYOFIBROBLAST; NEPHROBLASTOMA; OSSIFICATION; OSTEOID; STROMA CELL; TUMOR VOLUME;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; DISEASE-FREE SURVIVAL; EPITHELIAL CELLS; FEMALE; HEPATECTOMY; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MALE; NEOPLASMS, COMPLEX AND MIXED; SARCOMA, SYNOVIAL; STROMAL CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 11144304037     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000147398.03015.9e     Document Type: Article

References (41)

1. Allison RM, Willis RA. An ossifying embryonic mixed tumor of an infant's liver. J Pathol Bacteriol. 1956;72:155-159.
2. Barsky SH, Linnoila I, Triche TJ, et al. Hepatocellular carcinoma with carcinoid features. Hum Pathol. 1984;15:892-894.
3. Chu PG, Arber DA, Weiss LM. Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms: an immunohistochemical study of 447 cases. Am J Clin Pathol. 2003;120:64-70.
4. Clement PB, Young RH, Scully RE. Clinical syndromes associated with tumors of the female genital tract. Semin Diagn Pathol. 1991;8:204-233.
5. Costero-Barrios C, Lopez-Briano M. Extraovarian sex cord meschymatose tumor [translation from Spanish]. Gac Med Mex. 2003;139:611-616.
6. Crawford SM, Pyrah RD, Ismail SM. Cushing's syndrome associated with recurrent endometrioid adenocarcinoma of the ovary. J Clin Pathol. 1994;47:766-768.
7. Finegold MJ. Hepatic tumors in childhood. In: Russo P, Ruchelli E, Piccolo D, eds. Pathology of Pediatric Gastrointestinal and Liver Disease. New York: Springer-Verlag Telos, 2004:332.
8. Hannah J, Lippe B, Lai-Goldman M, et al. Oncocytic carcinoid of the kidney associated with periodic Cushing's syndrome. Cancer. 1988;61:2136-2140.
9. Heywood G, Burgart LJ, Nagorney DM. Ossifying malignant mixed epithelial and stromal tumor of the liver: a case report of a previously undescribed tumor. Cancer. 2002;94:1018-1022.
10. Hildebrandt R, Rouse R, Longacre T. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol. 1997;28:1387-1395.
11. Hill DA, Swanson PE, Covinsky MH, et al. Desmoplastic nested spindle cell tumor of the liver: report of a new entity. In: Society for Pediatric Pathology, Interim Meeting. Cincinnati, OH, 2003.
12. Hsueh C, Xiao-Di T, Gonzalez-Crussi F. Primary hepatic neuroendocrine carcinoma in a child: morphologic, immunocytochemical, and molecular biologic studies. Cancer. 1983;71:2660-2665.
13. Huber SM, Braun GS, Segerer S, et al. Metanephrogenic mesenchyme to epithelium transition induces profound expression changes of ion channels. Am Physiol Renal Physiol. 2000;279:F65-F76.
14. Ishak KG, Goodman ZD, Stocker JT. Miscellaneous malignant tumors (chapter 11). In: Rosai J, Sobin LH, eds. Tumors of the Liver and Intrahepatic Bile Ducts. Washington, DC: Armed Forces Institute of Pathology, 2001:276-278.
15. Ishak KG, Goodman ZD, Stocker JT. Miscellaneous malignant tumors (chapter 11). In: Rosai J, Sobin LH, eds. Tumors of the Liver and Intrahepatic Bile Ducts. Washington, DC: Armed Forces Institute of Pathology, 2001:271-272.
16. Keitoku M, Konishi I, Nanbu K, et al. Extraovarian sex-cord-stromal tumor: case report and review of the literature. Int J Gynecol Pathol. 1997;16:180-185 Miscellaneous malignant tumors (chapter 11). In: Rosai J, Sobin LH, eds. Tumors of the Liver and Intrahepatic Bile Ducts. Washington, DC: Armed Forces Institute of Pathology, 2001.
17. Keitoku M, Konishi I, Nanbu K, et al. Extraovarian sex-cord-stromal tumor: case report and review of the literature. Int J Gynecol Pathol. 1997;16:180-185 Miscellaneous malignant tumors (chapter 11). In: Rosai J, Sobin LH, eds. Tumors of the Liver and Intrahepatic Bile Ducts. Washington, DC: Armed Forces Institute of Pathology, 2001.
18. Khoo US, Nichols JM, Lee JSK, et al. Cholestatic liver cell adenoma in a child with hirsutism and elevated serum levels of cortisol and ACTH. Histopathology. 1994;25:586-588.
19. Kim S, Park H, Linton J, et al. Extraovarian granulosa cell tumor. Yonsei Med J. 2001;42:360-363.
20. Krishnamurthy SC, Dutta V, Pai SA, et al. Primary carcinoid tumor of the liver: report of four resected cases including one with gastrin production. J Surg Oncol. 1996;62:218-221.
21. Kuo T. Pigmented spindle cell carcinoid tumor of the thymus with ectopic adrenocorticotropic hormone secretion: report of a rare variant and differential diagnosis of mediastinal spindle cell neoplasms. Histopathology. 2002;40:159-165.
22. Ladomery M, Dellaire G. Multifunctional zinc finger proteins in development and disease. Ann Hum Genet. 2002;66:331-342.
23. Ludwig J, Grier MW, Hoffman HN, et al. Calcified mixed malignant tumor of the liver. Arch Pathol. 1975;99:162-166.
24. Manivel C, Wick MR, Abendoza P, et al. Teratoid hepatoblastoma: the nosologic dilemma of solid embryonic neoplasms of childhood. Cancer. 1986;57:2168-2174.
25. Moran CA, Suster S. Spindle-cell neuroendocrine carcinomas of the thymus (spindle-cell thymic carcinoid): a clinicopathologic and immunohistochemical study of seven cases. Mod Pathol. 1999;12:587-591.
26. Orbetzova M, Andreeva M, Zacharieva S, et al. Ectopic ACTH-syndrome due to ovarian carcinoma. Exp Clin Endocrinol Diabetes. 1997;105:363-365.
27. Rabl W, Muller OA, Welsch U, et al. Ectopic ACTH syndrome, and 'tumor hypercalcemia' due to a hepatoblastoma [Abstract]. Pediatr Res. 1988;23:137.
28. Ranchod M, Levine GD. Spindle-cell carcinoid tumors of the lung: a clinicopathologic study of 35 cases. Am J Surg Pathol. 1980;4:315-331.
29. Robinson J, Im D, Logan L, et al. Extraovarian granulosa cell tumor. Gynecol Oncol. 1999;74:123-127.
30. Roskams T, van den Oord JJ, De Vos R, et al. Neuroendocrine features of reactive bile ductules in cholestatic liver disease. Am J Pathol. 1990;137:1019-1025.
31. Ruck P, Harms D, Kaiserling E. Neuroendocrine differentiation in hepatoblastoma: an immunohistochemical investigation. Am J Surg Pathol. 1990;14:847-855.
32. Ruck P, Kaiserling E. Melanin-containing hepatoblastoma with endocrine differentiation: an immunohistochemical and ultrastructural study. Cancer. 1993;72:361-368.
33. Sainio K, Hellstedt P, Kreidberg JA, et al. Differential regulation of two sets of mesonephric tubules by WT-1. Development. 1997;124:1293-1299.
34. Scharnhorst V, van der Eb A, Jochemsen AG. WT1 proteins: functions in growth and differentiation. Gene. 2001;273:141-161.
35. Schlaghecke R, Kreuzpaintner G, Burrig KF, et al. Cushing's syndrome due to ACTH-production of an ovarian carcinoid. Klin Wochenschr. 1989;67:640-644.
36. Torbenson M, Wang J, Abraham S, et al. Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresia. Am J Surg Pathol. 2003;27:1454-1457.
37. Van den Heuvel MC, Sloof MJ, Visser L, et al. Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers. Hepatology. 2001;33:1387-1393.
38. Wang J, Dhillon AP, Sankey EA, et al. 'Neuroendocrine' differentiation in primary neoplasms of the liver. J Pathol. 1991;163:61-67.
39. Wilkins L, Ravitch MM. Adrenocortical tumor arising in the liver of a three year old boy with signs of virilism and Cushing's syndrome: report of a case with cure after partial resection of the right lobe of the liver. Pediatrics. 1952;9:671-681.
40. Yamashina M. An 18-year history of a corticotropin-secreting spindle cell carcinoid in the lung. Arch Pathol Lab Med. 1985;109:673-675.
41. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary: a clinicopathologic analysis of 125 cases. Am J Surg Pathol. 1984;8:575-596.