Relation of hypoxia-inducible factor-1α to vascular endothelial growth factor and vasoactive factors during healing of gastric ulcers

Journal of Cardiovascular Pharmacology

Volumn 44, Issue SUPPL. 1, 2004, Pages

  Hashimoto, Hiroshi ^a,b   Akimoto, Masumi ^b   Maeda, Atsushi ^b   Shigemoto, Mutsuo ^b   Yamashito, Katsuko ^b  

^a JR Tokyo General Hospital   (Japan)

^b Tokyo Women s Medical University   (Japan)

Author keywords

Endothelin 1; Hypoxia inducible factor 1 ; Inducible nitric oxide synthase; Ulcer healing; Vascular endothelial growth factor

Indexed keywords

ANGIOGENIC FACTOR; ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; VASCULOTROPIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANGIOGENESIS; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DIGESTIVE TRACT ENDOSCOPY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SCAR FORMATION; STOMACH MUCOSA; STOMACH ULCER; TISSUE OXYGENATION; TRANSCRIPTION REGULATION; ULCER HEALING;

CASE-CONTROL STUDIES; ENDOTHELIN-1; GASTRIC MUCOSA; GASTROSCOPY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; STOMACH ULCER; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 11144301286     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000166305.79055.ad     Document Type: Conference Paper

References (14)

1. Akimoto M, Hashimoto H, Shigemoto M, et al. Changes of nitric oxide and growth factors during gastric ulcer healing. J Cardiovasc Pharmacol. 2000;36(5 suppl. 1):S282-S285.
2. Akimoto M, Hashimoto H, Shigemoto M, et al. Relationship between recurrence of gastric ulcer and the microcirculation. J Cardiovasc Pharmacol. 1998;31(suppl. 1):S507-S508.
3. Hashimoto H, Akimoto M, Maeda A, et al. Changes in vasoactive substances during gastric ulcer healing. J Cardiovasc Pharmacol. 2000;36(5 suppl. 1):S278-S281.
4. Takahashi M, Kawabe T, Ogura K, et al. Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing. Biochem Biophys Res Commun. 1997;234:493-498.
5. 2 tension. Proc Natl Acad Sci U.S.A. 1995;92:5510-5514.
6. Kakinuma Y, Miyauchi T, Suzuki T, et al. Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha. Clin Sci (Lond). 2002;103(suppl. 48):210S-214S.
7. Ao Q, Hao C, Xiong M, et al. Expression of hypoxia-inducible factor-1 alpha and endothelin-1 gene in hypoxic pulmonary hypertension. Zhonghua Bing Li Xue Za Zhi. 2002;31:140-142.
8. Spinella F, Rosano L, Di Castro V, et al. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1 alpha in ovarian carcinoma cells. J Biol Chem. 20022;277:27850-27855.
9. Baatar D, Jones MK, Tsugawa K, et al. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing. Am J Pathol. 2002;161:1101-1105.
10. Buchler P, Reber HA, Bucher M, et al. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas. 2003;26:56-64.
11. Hierholzer C, Billiar TR.Molecular mechanisms in the early phase of hemorrhagic shock. Langenbecks Arch Surg. 2001;386:302-308.
12. Yang DI, Yin JH, Mishra S, et al. NO-mediated chemoresistance in C6 glioma cells. Ann NY Acad Sci. 2002;962:8-17.
13. Huang LE, Arany Z, Livingston DM, et al. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem. 1996;271:32253-32259.
14. Kallio PJ, Pongratz I, Gradin K, et al. Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci U.S.A. 1997;94:5667-5672.