Peptide immunogens designed to enhance immune responses against human immunodeficiency virus (HIV) mutant strains: A plausible means of preventing viral persistence

Journal of Theoretical Biology

Volumn 233, Issue 1, 2005, Pages 85-90

  Hewer, R ^a   Meyer, D ^a  

^a UNIVERSITY OF JOHANNESBURG   (South Africa)

Author keywords

Antigenic variation; Envelope; Human immunodeficiency virus; Synthetic immunogens; Viral persistence

Indexed keywords

ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PEPTIDE;

HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNITY; IMMUNOSTIMULATION; INFECTION PREVENTION; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; RABBIT; VACCINE PRODUCTION; VIRUS ENVELOPE; VIRUS STRAIN; VIRUS VIRULENCE;

AIDS VACCINES; ANTIGENIC VARIATION; HIV INFECTIONS; HIV-1; HUMANS; MODELS, IMMUNOLOGICAL; MUTATION; VACCINES, SYNTHETIC; VIRULENCE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS;

EID: 11144256552     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtbi.2004.09.008     Document Type: Article

References (17)

1. P. Balfe, P. Simmonds, C.A. Ludlam, J.O. Bishop, and A.J. Leigh-Brown Concurrent evolution of human immunodefiency virus type 1 in patients infected from the same source rate of sequence change and low frequency of inactivating mutations J. Virol. 64 1990 6221 6233
2. K. Bebenek, J. Abbotts, J.D. Roberts, S.H. Wilson, and T.A. Kunkel Specificity and mechanism of error-prone replication by human immunodeficiency virus-1 reverse transcriptase J. Biol. Chem. 264 1989 16,948 16,956
3. + T cells but a high proportion of replication-competent provirus copies in asymptomatic human immunodefiency virus type 1 infection J. Virol. 65 1991 2019 2023
4. J.M. Coffin Genetic diversity and evolution of retroviruses Curr. Top. Microbiol. Immunol. 176 1992 143 164
5. M. Goodenow, T. Huet, W. Saurin, S. Kwok, J. Sninsky, and S. Wain-Hobson HIV-1 isolates are rapidly evolving quasispecies evidence for viral mixtures and preferred nucleotide substitutions J. AIDS 2 1989 344 352
6. Hewer, R., Meyer, D., 2002. Producing a highly immunogenic synthetic vaccine construct active against HIV-1 subtype C. Vaccine 2680-2683; doi: 10.1016/S0264-410X(02)00213-X.
7. R. Hewer, and D. Meyer Peptide immunogens based on the envelope region of HIV-1 are recognized by HIV/AIDS patient polyclonal antibodies and induce strong humoral immune responses in mice and rabbits Mol. Immunol. 40 6 2003 327 335 10.1016/S0161-5890(03)00163-9
8. E.G.J. Hulskotte, A.M. Geretti, and A.D.M. E. Osterhaus Towards an HIV-1 vaccine lessons from studies in macaque models Vaccine 16 9/10 1998 904 915
9. M. Klein AIDS and HIV vaccines Vaccine 17 1999 S65 S70
10. D. Meyer, D.E. Anderson, M.B. Gardner, and J.V. Torres Hypervariable epitope constructs representing variability in envelope glycoprotein of SIV induce a broad humoral immune response in rabbits and rhesus macaques AIDS Res. Hum. Retroviruses 14 9 1998 751 760
11. A. Meyerhans, R. Cheynier, J. Albert, M. Seth, S. Kwok, J. Sninsky, L. Morfeldt-Mamson, B. Asjö, and S. Wain-Hobson Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations Cell 58 1989 901 910
12. L. Mints, R.H. Angeletti, and E. Nieves Analysis of MAPS peptides ABRF News 8 1997 22 26
13. M.A. Nowak, and A.R. Mclean A mathematical model of vaccination against HIV prevent the development of AIDS Proc. Biol. Sci. 246 1316 1991 141 146
14. M.A. Nowak, R.M. Anderson, M.C. Boerlijst, S. Bonhoeffer, R.M. May, A.J. McMichael, S.M. Wolinsky, K.J. Kunstman, J.T. Safrit, R.A. Koup, A.U. Neumann, and B.T.M. Korber HIV-1 evolution and disease progression Science 274 5289 1996 1008 1011
15. D.N. Posnett, H. Grath, and J.P. Tam A novel method for producing anti-peptide antibodies J. Biol. Chem. 263 4 1988 1719 1725
16. J.D. Roberts, K. Bebenek, and T.A. Kunkel The accuracy of reverse transcriptase from HIV-1 Science 242 1988 1171 1173
17. Vasil, S., Thakallapally, R., Korber, B.T., Foley, B.T., 1998. Global variation in the HIV-1 V3 region. In: Korber, B.T., Kuiken, C.L., Foley, B., Hahn, B., McCutchan, F., Mellors, J.W., Sodroski, J. (Eds.), Human Retroviruses and AIDS Research: A Compilation and Analysis of Nucleic Acids and Amino Acid Sequences. Theoretical Biology and Biophysics Group. Los Alamos National Laboratory, Los Alamos, NM, p. III-118-129.