Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: An hypothesis

Medical Hypotheses

Volumn 64, Issue 3, 2005, Pages 563-567

  Guizzetti, Marina ^a   Costa, Lucio G ^a,b  

^a Sch Vet Med Univ W   (United States)

^b UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PHENYLACETIC ACID; PHENYLALANINE;

ARTICLE; ASTROCYTE; ATHEROSCLEROSIS; BRAIN DEVELOPMENT; BRAIN INJURY; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM DISEASE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; DENDRITE; DISEASE SEVERITY; FETAL ALCOHOL SYNDROME; GENETIC DISORDER; HOLOPROSENCEPHALY; HOMEOSTASIS; HUMAN; HYPOTHESIS; INBORN ERROR OF METABOLISM; MENTAL DEFICIENCY; MICROCEPHALY; NERVE CELL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PHENYLKETONURIA; PRIORITY JOURNAL; SMITH LEMLI OPITZ SYNDROME; SYNAPSE;

ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; APOLIPOPROTEINS E; ASTROCYTES; BRAIN; CHOLESTEROL; ETHANOL; FEMALE; FETAL ALCOHOL SYNDROME; HOMEOSTASIS; HUMANS; MODELS, BIOLOGICAL; NEURONS; NEUROTOXICITY SYNDROMES; PHENYLKETONURIA, MATERNAL; PREGNANCY; SMITH-LEMLI-OPITZ SYNDROME;

EID: 11144255051     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.05.019     Document Type: Article

References (45)

1. A.P. Streissguth, S. Landesman-Dwyer, J.C. Martin, and D.W. Smith Teratogenic effects of alcohol in humans and laboratory animals Science 209 1980 353 361
2. K. Stratton, C. Howe, and F. Battaglia Fetal alcohol syndrome: diagnosis, epidemiology, prevention and treatment 1996 National Academy Press Washington (DC)
3. C. Guerri, M. Pascual, and J. Renau-Piqueras Glia and fetal alcohol syndrome Neurotoxicology 22 2001 593 599
4. Costa LG, Yagle K, Vitalone A, Guizzetti M. Alcohol and glia in the developing brain. In: Aschner M, Costa LG, editors. The role of glia in neurotoxicity. Boca Raton: CRC Press; 2004 [in press]
5. S.E. Maier, J.A. Miller, J.M. Blackwell, and J.R. West Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development Alcohol Clin Exp Res 23 1999 726 734
6. C. Ikonomidou, P. Bittigau, and M.J. Ishmaru Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome Science 287 2000 1056 1060
7. P.A. Yanni, and T.A. Lindsley Ethanol inhibits development of dendrites and synapses in rat hippocampal pyramidal neuron cultures Brain Res Dev Brain Res 120 2000 233 243
8. D.E. Smith, and D.L. Davies Effect of perinatal administration of ethanol on the CA1 pyramidal cell of the hippocampus and Purkinje cell of the cerebellum: an ultrastructural survey J Neurocytol 19 1990 708 717
9. A.K. Shetty, R.C. Burrows, and D.E. Phillips Alterations in neuronal development in the substantia nigra pars compacta following in utero ethanol exposure: immunohistochemical and golgi studies Neuroscience 52 1993 311 322
10. M. Guizzetti, M. Catlin, and L.G. Costa The effects of ethanol on glial cell proliferation: relevance to the Fetal Alcohol Syndrome Front Biosci 2 1997 e93 e98
11. L.A. Woollett The origins and roles of cholesterol and fatty acids in the fetus Curr Opin Lipidol 12 2001 305 312
12. J.M. Dietschy, and S.D. Turley Cholesterol metabolism in the brain Curr Opin Lipidol 12 2001 105 112
13. H.A. Jurevics, F.Z. Kidwai, and P. Morell Sources of cholesterol during development of the rat fetus and fetal organs J Lipid Res 38 1997 723 733
14. J. Dobbing, and J. Sands Comparative aspects of the brain growth spurt Early Hum Dev 3 1979 79 83
15. J.J. Kabara A critical review of brain cholesterol metabolism Prog Brain Res 40 1973 363 382
16. T.J. Langan, and M.C. Slater Quiescent astroglia in long-term primary cultures reenter the cell cycle and require a non-sterol isoprenoid in late G1 Brain Res 548 1991 9 17
17. D. Bochelen, M. Mersel, and P. Behr Effect of oxysterol treatment on cholesterol biosynthesis and reactive astrocyte proliferation in injured rat brain cortex J Neurochem 65 1995 2194 2200
18. D.H. Mauch, K. Nagler, and S. Schumacher CNS synaptogenesis promoted by a glia-derived cholesterol Science 294 2001 1354 1357
19. M. Michikawa, and K. Yanagisawa Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death J Neurochem 72 1999 2278 2285
20. Q.W. Fan, W. Yu, and J.S. Gong Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons J Neurochem 80 2002 178 190
21. R.E. Pitas, J.K. Boyles, and S.H. Lee Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins Biochim Biophys Acta 917 1987 148 161
22. J.J. Volpe, and S.W. Hennessy Cholesterol biosynthesis and 3-hydroxy-3-methylglutaryl coenzyme, A reductase in cultured glial and neuronal cells, Regulation by lipoprotein and by certain free sterols Biochim Biophys Acta 486 1977 408 420
23. R.P. Koldamova, I.M. Lefterov, and M.D. Ikonomovic 22R-Hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion J Biol Chem 278 2003 13244 13256
24. J Biol Chem 2002 10476 10481
25. E.M. Ullian, S.K. Sapperstein, K.S. Christopherson, and B.A. Barres Control of synapse number by glia Science 291 2001 657 661
26. J. Herz The LDL receptor gene family: (un)expected signal transducers in the brain Neuron 29 2001 571 581
27. R.I. Kelley, and G.E. Herman Inborn errors of sterol biosynthesis Annu Rev Genomics Hum Genet 2 2001 299 341
28. N.A. Nwokoro, C.A. Wassif, and F.D. Porter Genetic disorders of cholesterol biosynthesis in mice an humans Mol Genet Metab 74 2001 105 119
29. M.J. Nowaczyk, D.T. Whelan, T.W. Heshka, and R.E. Hill Smith-Lemli-Opitz syndrome: a treatable inherited error of metabolism causing mental retardation Can Med Assoc J 161 1999 165 170
30. H.L. Levy, and M. Ghavami Maternal phenylketonuria: a metabolic teratogen Teratology 53 1996 176 184
31. G.Y. Wen, H.M. Wisniewski, and J.W. Shek Neuropathology of phenylacetate poisoning in rats: an experimental model of phenylketonuria Ann Neurol 7 1980 557 566
32. L.G. Costa, M. Guizzetti, M. Burry, and J. Oberdoerster Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria Toxicol Lett 127 2002 197 205
33. M.M. Cohen, and K. Shiota Teratogenesis of holoprosencephaly Am J Med Genet 109 2002 1 15
34. K. Keller, H. McCune, C. Williams, and M. Muenke Lobar holoprosencephaly in an infant born to a mother with classic phenylketonuria Am J Med Genet 95 2000 187 188
35. S.C. Ahlgren, V. Thakur, and M. Bronner-Fraser Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure Proc Natl Acad Sci USA 99 2002 10476 10481
36. M.L. Hannuksela, M.K. Liisanantt, and M.J. Savolainen Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis Crit Rev Clin Lab Sci 39 2002 225 283
37. A. Ruitenberg, J.C. van Swieten, and J.C. Witteman Alcohol consumption and risk of dementia: the rotterdam study Lancet 359 2002 281 286
38. M.C. Sanchez-Amate, J.M. Zurera, and M.P. Carrasco Ethanol and lipid metabolism. Differential effects on liver and brain microsomes FEBS Lett 293 1991 215 218
39. K.A. Grant, and H.H. Samson Ethanol and tertiary butanol induced microencephaly in the neonatal rat: comparison of brain growth parameters Neurobehav Toxicol Teratol 4 1982 315 321
40. K.A. Grant, and H.H. Samson n-Propanol induced microencephaly in the neonatal rat Neurobehav Toxicol Teratol 6 1984 165 169
41. P. Ghosh, E.A. Hale, and K. Mayur Effects of chronic alcohol treatment on the synthesis, sialylation, and disposition of nascent apolipoprotein E by peritoneal macrophages of rats Am J Clin Nutr 72 2000 190 198
42. N.A. Avdulov, S.V. Chochina, U. Igbavboa, and W.G. Wood Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol Biochem 39 2000 10599 10606
43. N.A. Avdulov, S.V. Chochina, and U. Igbavboa Lipid binding to sterol carrier protein-2 is inhibited by ethanol Biochim Biophys Acta 1437 1999 37 45
44. D.L. Sparks, H. Liu, D.R. Gross, and S.W. Scheff Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brains after dietary administration of cholesterol Neurosci Lett 187 1995 142 144
45. P.A. Krakowiak, C.A. Wassif, and L. Kratz Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency Hum Mol Genet 12 2003 1631 1641