Cellular immune responses in the lungs of pigs infected in Utero with PRRSV: An immunohistochemical study

Viral Immunology

Volumn 17, Issue 4, 2004, Pages 558-564

  Tingstedt, Jens Erik ^a   Nielsen, Jens ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD2 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTERIVIRUS; ARTICLE; CELL STRUCTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOUBLE STAINING; IMMUNOHISTOCHEMISTRY; INTRAUTERINE INFECTION; LUNG INFECTION; LYMPHOCYTE HOMING; NEWBORN; NONHUMAN; PHENOTYPE; STAINING; SWINE; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALIA; ARTERIVIRUS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; RNA VIRUSES; SUIDAE; SUS SCROFA;

EID: 11144248486     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2004.17.558     Document Type: Article

References (40)

1. Aasted, B., P. Bach, J. Nielsen, et al. 2002. Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus. Clin. Diagn. Lab. Immunol. 9:1229-34.
2. Albina, E., L. Piriou, E. Hutet, et al. 1998. Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Immunol. Immunopathol. 61:49-66.
3. Bautista, E.M., S.M. Goyal, I.J. Yoon, et al. 1993. Comparison of porcine alveolar macrophages and CL 2621 for the detection of porcine reproductive and respiratory syndrome (PRRS) virus and anti-PRRS antibody. J. Vet. Diagn. Invest. 5:163-5.
4. Bautista, E.M., and T.W. Molitor. 1997. Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine. Viral Immunol. 10:83-94.
5. Benfield, D.A., J. Nelson, and K. Rossow. 1998. Pathogenesis and persistence of PRRS. Presented at the Leman Conference.
6. Beyer, J., D. Fichtner, H. Schirrmeier, et al. 2000. Porcine reproductive and respiratory syndrome virus (PRRSV): kinetics of infection in lymphatic organs and lung. J. Vet. Med. B. Infect. Dis. Vet. Public Health 47:9-25.
7. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:6103-10.
8. Bøtner, A., J. Nielsen, and V. Bille-Hansen. 1994. Isolation of porcine reproductive and respiratory syndrome (PRRS) virus in a Danish swineherd and experimental infection of pregnant gilts with the virus. Vet. Microbial. 40:351-60.
9. + T cells in acute infectious mononucleosis. Nat. Med. 2:906-11.
10. Christopher-Hennings, J., E.A. Nelson, R.J. Hines, et al. 1995. Persistence of porcine reproductive and respiratory syndrome virus in serum and semen of adult boars. J. Vet. Diagn. Invest. 7:456-64.
11. Collins, J.E., D.A. Benfield, W.T. Christianson, et al. 1992. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J. Vet. Diagn. Invest. 4:117-26.
12. Drew, T.W. 2000. A review of evidence for immunosuppression due to porcine reproductive and respiratory syndrome virus. Vet. Res. 1:27-39.
13. Duan, X., H.J. Nauwynck, and M.B. Pensaert. 1997. Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 56:9-19.
14. Feng, W., S.M. Laster, M. Tompkins, et al. 2001. In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II. J. Virol. 75:4889-95.
15. Feng, W.H., M.B. Tompkins, J.S. Xu, et al. 2002. Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus. Virology 302:363-72.
16. Feng, W.H., M.B. Tompkins, J.S. Xu, et al. 2003. Analysis of constitutive cytokine expression by pigs infected inutero with porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 94:35-45.
17. Johnsen, C.K., A. Bøtner, S. Kamstrup, et al. 2002. Cytokine mRNA profiles in bronchoalveolar cells of piglets experimentally infected in utero with porcine reproductive and respiratory syndrome virus: association of sustained expression of IFN-gamma and IL-10 after viral clearance. Viral Immunol. 15:549-56.
18. + T cells in influenza virus-infected mice. Proc. Natl. Acad. Sci. USA 100:2657-62.
19. Keffaber, K.K. 1989. Reproductive failure of unknown etiology. Am. Assoc. Swine Pract. Newslett. 1:1-9.
20. Kranker, S., J. Nielsen, V. Bille-Hansen, et al. 1998 Experimental inoculation of swine at various stages of gestation with a Danish isolate of porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 15:21-31.
21. Labarque, G.G., H.J. Nauwynck, K. Van Reeth, et al. 2000. Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J. Gen. Virol. 81:1327-34.
22. Molitor, T.W., E.M. Bautista, and C.S. Choi. 1997. Immunity to PRRSV: double-edged sword. Vet. Microbiol. 55:265-76.
23. Murtaugh, M.P., Z. Xiao, and F. Zuckermann. 2002. Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral Immunol. 15:533-47.
24. Nelson, E.A., J. Christopher-Hennings, T. Drew, et al. 1993. Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies. J. Clin. Microbiol. 31:3184-9.
25. Nielsen, J., A. Bøtner, J.E. Tingstedt, et al. 2003. In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving piglets. Vet. Immunol. Immunopathol. 93:135-51.
26. Plagemann, P.G., and V. Moennig. 1992. Lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses Adv. Virus Res. 41:99-192.
27. Pol, J.M., J.E. van Dijk, G. Wensvoort, et al. 1991. Pathological, ultrastructural, and immunohistochemical changes caused by Lelystad virus in experimentally induced infections of mystery swine disease (synonym: porcine epidemic abortion and respiratory syndrome [PEARS]). Vet. Q. 13:137-43.
28. Pollard, K., D. Lunny, C.S. Holgate, et al. 1987. Fixation, processing, and immunochemical reagent effects on preservation of T-lymphocyte surface membrane antigens in paraffin-embedded tissue. J. Histochem. Cytochem. 35:1329-38.
29. Rossow, K.D., J.E. Collins, S.M. Goyal, et al. 1995. Pathogenesis of porcine reproductive and respiratory syndrome virus infection in gnotobiotic pigs. Vet. Pathol. 32:361-73.
30. Rowland, R.R., S. Lawson, K. Rossow, et al. 2003. Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero. Vet. Microbiol. 96:219-35.
31. + cells. J. Gen. Virol. 81:497-505.
32. Shimizu M., S. Yamada, K. Kawashima, et al. 1996. Changes of lymphocyte subpopulations in pigs infected with porcine reproductive and respiratory syndrome (PRRS) virus. Vet. Immunol. Immunopathol. 50:19-27.
33. Taylor, G., L.H. Thomas, S.G. Wyld, et al. 1995. Role of T-lymphocyte subsets in recovery from respiratory syncytial virus infection in calves. J. Virol. 69:6658-64.
34. Thanawongnuwech, R., A. Rungsipipat, S. Disatian, et al. 2003. Immunohistochemical staining of IFN-gamma positive cells in porcine reproductive and respiratory syndrome virus-infected lungs. Vet. Immunol. Immunopathol. 91:73-7.
35. Tingstedt, J.E., D. Tornehave, P. Lind, et al. 2003. Immunohistochemical detection of SWC3, CD2, CD3, CD4 and CD8 antigens in paraformaldehyde fixed and paraffin embedded porcine lymphoid tissue. Vet. Immunol. Immunopathol. 94:123-32.
36. Wensvoort, G., C. Terpstra, J.M. Pol, et al. 1991. Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet. Q. 13:121-30.
37. Wensvoort, G., E.P. de Kluyver, E.A. Luijtze, et al. 1992. Antigenic comparison of Lelystad virus and swine infertility and respiratory syndrome (SIRS) virus. J. Vet. Diagn. Invest. 4:134-8.
38. Whiteland, J.L., S.M. Nicholls, C. Shimeld, et al. 1995. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J. Histochem. Cytochem. 43:313-20.
39. Wills, R.W., A.R. Doster, J.A. Galeota, et al. 2003. Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus. J. Clin. Microbiol. 41:58-62.
40. Zhou, Y., S. Barghusen, C. Choi, et al. 1992. Effect of SIRS virus infection in leukocyte populations in the peripheral blood and on cytokine expression in alveolar macrophages of growing pigs. Am. Assoc. Swine Pract. Newslett. 4:28.