Cardiac DT-diaphorase contributes to the detoxification system against doxorubicin-induced positive inotropic effects in guinea-pig isolated atria

Clinical and Experimental Pharmacology and Physiology

Volumn 31, Issue 12, 2004, Pages 856-861

  Badary, Osama A ^a   Awad, Azza S ^b   Abdel Maksoud, Sahar ^c   Hamada, Farid M A ^c  

^a Helwan   (Egypt)

^b AL AZHAR UNIVERSITY   (Egypt)

^c Al Azhar University   (Egypt)

Author keywords

Atria; Cardiotoxicity; Detoxification; Diaphorase; Doxorubicin; Guinea pig; Inotropic; Metabolism; Phase II enzymes; Superoxide

Indexed keywords

3 METHYLCHOLANTHRENE; DICOUMAROL; DOXORUBICIN; GLUTATHIONE TRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG DETOXIFICATION; ENZYME ACTIVITY; GUINEA PIG; HEART ATRIUM CONTRACTILITY; INOTROPISM; MALE; NONHUMAN;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ENZYME INDUCTION; ENZYME INHIBITORS; GUINEA PIGS; HEART ATRIA; MALE; METABOLIC DETOXICATION, DRUG; MYOCARDIAL CONTRACTION; NAD(P)H DEHYDROGENASE (QUINONE); STIMULATION, CHEMICAL;

EID: 11144248036     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2004.04126.x     Document Type: Article

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