Temporary CD8+ T-cell depletion in pigs does not exacerbate infection with porcine reproductive and respiratory syndrome virus (PRRSV)

Viral Immunology

Volumn 17, Issue 4, 2004, Pages 594-603

  Lohse, Louise ^a,b   Nielsen, Jens ^a   Eriksen, Lis ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; OKT 8;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTERIVIRUS; ARTICLE; CLEARANCE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; IMMUNE DEFICIENCY; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERSISTENT VIRUS INFECTION; SWINE DISEASE; T LYMPHOCYTE SUBPOPULATION; VIRUS CLEARANCE; VIRUS INFECTION;

ANIMALIA; ARTERIVIRUS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; RNA VIRUSES; SUIDAE; SUS SCROFA;

EID: 11144241414     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2004.17.594     Document Type: Article

References (29)

1. Albina, E., L. Piriou, E. Hutet, et al. 1998. Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Immunol. Immunopathol. 61:49-66.
2. Allan, J.S., J.K. Choo, L. Vesga, et al. 1997. Cardiac allograft vasculopathy is abrogated by anti-CD8 monoclonal antibody therapy. Ann. Thorac. Surg. 64:1019-1025.
3. Bautista, E.M., and T.W. Molitor. 1997. Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine. Viral Immunol. 10:83-94.
4. Bøtner, A., J. Nielsen, and V. Bille-Hansen. 1994. Isolation of porcine reproductive and respiratory syndrome (PRRS) virus in a Danish swine herd and experimental infection of pregnant gilts with the virus. Vet. Microbiol. 40:351-360.
5. Duan, X., H.J. Nauwynck, and M.B. Pensaert. 1997. Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 56:9-19.
6. Halbur, P.G., P.S. Paul, M.L. Frey, et al. 1995. Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol. 32:648-660.
7. Kohler, G., and C. Milstein. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497.
8. Kranker, S., J. Nielsen, V. Bille-Hansen, et al. 1998. Experimental inoculation of swine at various stages of gestation with a Danish isolate of porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 61:21-31.
9. Labarque, G.G., H.J. Nauwynck, K. Van Reeth, et al. 2000. Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J. Gen. Virol. 81:1327-1334.
10. Ladekjaer-Mikkelsen, A.S., J. Nielsen, T. Stadejek, et al. 2002. Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old pigs experimentally infected with porcine circovirus type 2 (PCV2). Vet. Microbiol. 89:97-114.
11. Lager, K.M., and P.G. Halbur. 1996. Gross and microscopic lesions in porcine fetuses infected with porcine reproductive and respiratory syndrome virus. J. Vet. Diagn. Invest. 8:275-82.
12. Loemba, H.D., S. Mounir, H. Mardassi, et al. 1996. Kinetics of humoral immune response to the major structural proteins of the porcine reproductive and respiratory syndrome virus. Arch. Virol. 141:751-761.
13. López-Fuertes, L., N. Doménech, B. Alvarez, et al. 1999. Analysis of cellular immune response in pigs recovered from porcine respiratory and reproductive syndrome infection. Virus Res. 64:33-42.
14. Molitor, T.W., J. Xiao, and C.S. Choi. 1996. PRRS virus infection of macrophages: regulation by maturation and activation state. Am. Assoc. Swine Pract. 27:563-569.
15. Molitor, T.W., E.M. Bautista, and C.S. Choi. 1997. Immunity to PRRSV: double-edged sword. Vet. Microbiol. 55:265-276.
16. Nielsen, J., and A. Bøtner. 1997. Hematological and immunological parameters of 4 1/2-month-old pigs infected with PRRS virus. Vet. Microbiol. 55:289-294.
17. Nielsen, J., A. Bøtner, V. Bille-Hansen, et al. 2002. Experimental inoculation of late term pregnant sows with a field isolate of porcine reproductive and respiratory syndrome vaccine-derived virus. Vet. Microbiol. 84:1-13.
18. Nielsen, J., A. Bøtner, J.E. Tingstedt, et al. 2003. In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving pigs. Vet. Immunol. Immunopathol. 93:135-151.
19. Nielsen, T.L., J. Nielsen, P. Have, et al. 1997. Examination of virus shedding in semen from vaccinated and from previously infected boars after experimental challenge with porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 54:101-112.
20. Oleksiewicz, M.B., and J. Nielsen. 1999. Effect of porcine reproductive and respiratory syndrome virus (PRRSV) on alveolar lung macrophage survival and function. Vet. Microbiol. 66:15-27.
21. Pescovitz, M.D., J.K. Lunney, and D.H. Sachs. 1984. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J. Immunol. 133:368-375.
22. Rossow, K.D. 1998. Porcine reproductive and respiratory syndrome. Vet. Pathol. 35:1-20.
23. + cells. J. Gen. Virol. 81:497-505.
24. Shimizu, M., S. Yamada, K. Kawashima, et al. 1996. Changes of lymphocyte subpopulations in pigs infected with porcine reproductive and respiratory syndrome (PRRS) virus. Vet. Immunol. Immunopathol. 50:19-27.
25. Smith, C.V., T. Sablinski, J.S. Arn, et al. 1994. In vivo treatment with monoclonal antibodies directed against CD4 and CD8 antigens in miniature swine. J. Immunother. Emphasis Tumor Immunol. 16:105-114.
26. high+ T-cells before onset of viraemia during classical swine fever. Vet. Immunol. Immunopathol. 78:3-19.
27. Suzuki, T., T.M. Sundt III, A. Mixon, et al. 1990. In vivo treatment with antiporcine T cell antibodies. Transplantation 50:76-81.
28. Sørensen, K.J., B. Strandbygaard, A. Bøtner, et al. 1998. Blocking ELISA's for the distinction between antibodies against European and American strains of porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 60:169-177.
29. Vézina, S.A., H. Loemba, M. Fournier, et al. 1996. Antibody production and blastogenic response in pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Can. J. Vet. Res. 60:94-99.