A child with vitamin B12 deficiency presenting with pancytopenia and hyperpigmentation

Journal of Pediatric Hematology/Oncology

Volumn 26, Issue 12, 2004, Pages 834-836

  Şimşek, Özlem Pelin ^a   Gönç, Nazli ^a   Gümrük, Fatma ^a   Çetin, Mualla ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Children; Hyperpigmentation; Pancytopenia; Vitamin B12 deficiency

Indexed keywords

CYANOCOBALAMIN; IRON; METHYLMALONIC ACID;

ARTICLE; BONE MARROW BIOPSY; BREAST FEEDING; CASE REPORT; CLINICAL FEATURE; CYANOCOBALAMIN DEFICIENCY; DEVELOPMENTAL DISORDER; DISEASE COURSE; DISEASE SEVERITY; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; IRON THERAPY; LABORATORY TEST; LEUKOCYTE COUNT; MEAN CORPUSCULAR VOLUME; MEGALOBLASTIC ANEMIA; NEUROLOGIC DISEASE; PANCYTOPENIA; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHILLING TEST; SOCIOECONOMICS; TREMOR; URINE LEVEL; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

ANEMIA, MEGALOBLASTIC; FEMALE; HUMANS; HYPERPIGMENTATION; INFANT; PANCYTOPENIA; TREATMENT OUTCOME; TREMOR; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 10944245290     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Lee GR. Megaloblastic and nonmegaloblastic macrocytic anemias. In: Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN, eds. Wintrobe's Clinical Hematology, 9th ed. Philadelphia: Lea & Febiger, 1993:745-790.
2. Zimran A, Hershko C. The changing pattern of megaloblastic anemia: megaloblastic anemia in Israel. Am J Clin Nutr. 1983;37:855-861.
3. Altay C, Çetin M. Gümrük F, et al. Familial selective vitamin B12 malabsorption (Imerslund-Grasbeck syndrome) in a pool of Turkish patients. Pediatr Hematol Oncol. 1995;12:19-28.
4. Doyle JJ, Langevin AM, Zipursky A. Nutritional vitamin B12 deficiency in infancy: three case reports and a review of the literature. Pediatr Hematol Oncol. 1989;6:161-172.
5. Kuhne T, Bubl R, Baumgartner R. Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency. Eur J Pediatr. 1991;150:205-208.
6. Emery ES, Homans AC. Vitamin B12 deficiency: a cause of abnormal movements in infants. Pediatrics. 1997;99:255-256.
7. Kalayci O, Çetin M, Kirel B, et al. Neurologic findings of vitamin B12 deficiency: presentation of 7 cases. Turk J Pediatr. 1996;38:67-72.
8. Rasmussen SA, Fernhoff PM, Scanlon KS. Vitamin B12 deficiency in children and adolescents. J Pediatr. 2001;138:7-10.
9. Allen LH. Vitamin B12 metabolism and status during pregnancy, lactation and infancy. In: Nutrient Regulation During Pregnancy, Lactation, and Infant Growth. New York: Plenum Press, 1994:173-186.
10. Garewal G, Narang A, Das KC. Infantile tremor syndrome: a vitamin B12 deficiency syndrome in infants. J Trop Pediatr. 1988;34:174-178.
11. Johnson PR, Roloff J. Vitamin B12 deficiency in an infant strictly breast-fed by a mother with latent pernicious anemia. J Pediatr. 1982;100:917-919.
12. Salameh MM, Banda RW, Mohdi AA. Reversal of severe neurological abnormalities after vitamin B12 replacement in the Imerslund-Grasbeck syndrome. J Neurol. 1991;238:349-350.
13. Weiss R, Fogelman Y, Bennett M. Severe vitamin B12 deficiency in an infant associated with maternal deficiency and a strict vegetarian diet. J Pediatr Hematol Oncol. 2004;26:270-271.
14. Allen LH, Rosado JL, Casterline JE, et al. Vitamin B12 deficiency and malabsorption are highly prevalent in rural Mexican communities. Am J Clin Nutr. 1995;62:1013-1019.
15. Von Schenck U, Gotze CB, Koletzko B. Persistence of neurological damage induced by dietary vitamin B12 deficiency in infancy. Arch Dis Child. 1997;77:137-139.
16. Casterline JE, Allen LH, Ruel MT. Vitamin B12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum. J Nutr. 1997;127:1966-1972.
17. Allen RH, Stabler SP, Savage DG, et al. Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol. 1990;34:90-98.
18. Hall CA. Function of vitamin B12 in the central nervous system as revealed by congenital defects. Am J Hematol. 1990;34:121-127.
19. Ozer EA, Turker M, Bakiler AR, et al. Involuntary movements in infantile cobalamin deficiency appearing after treatment. Pediatr Neurol. 2001;25:81-83.
20. Graham SM, Arvela OM, Wise GA. Long-term neurological consequences of nutritional VB12 deficiency in infants. J Pediatr. 1992;121:710-714.
21. Sabatino D, Kosuri S, Remollino A, et al. Cobalamin deficiency presenting with cutaneous hyperpigmentation: a report of two siblings. Pediatr Hematol Oncol. 1998;15:447-450.
22. Hoffman CF, Palmer DM, Papadopoulos D. Vitamin B12 deficiency: a case report of ongoing cutaneous hyperpigmentation. Cutis. 2003;71:127-130.