Alternative splicing of conserved exons is frequently species-specific in human and mouse

Trends in Genetics

Volumn 21, Issue 2, 2005, Pages 73-77

  Pan, Qun ^a   Bakowski, Malina A ^a   Morris, Quaid ^a   Zhang, Wen ^a   Frey, Brendan J ^a   Hughes, Timothy R ^a   Blencowe, Benjamin J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COMPARATIVE GENOMIC HYBRIDIZATION; COMPLEX FORMATION; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; EXON; GENE DISRUPTION; GENE FREQUENCY; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN GENOME; MATHEMATICAL COMPUTING; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; RNA SPLICING; SPECIES COMPARISON; STATISTICAL SIGNIFICANCE; VALIDATION PROCESS;

MAMMALIA;

EID: 10944245056     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2004.12.004     Document Type: Short Survey

References (10)

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3. T. Maniatis, and B. Tasic Alternative pre-mRNA splicing and proteome expansion in metazoans Nature 418 2002 236 243
4. D. Brett Alternative splicing and genome complexity Nat. Genet. 30 2002 29 30
5. B. Modrek, and C.J. Lee Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss Nat. Genet. 34 2003 177 180
6. T.A. Thanaraj Conservation of human alternative splice events in mouse Nucleic Acids Res. 31 2003 2544 2552
7. R.N. Nurtdinov Low conservation of alternative splicing patterns in the human and mouse genomes Hum. Mol. Genet. 12 2003 1313 1320
8. R. Sorek How prevalent is functional alternative splicing in the human genome? Trends Genet. 20 2004 68 71
9. Z. Kan Selecting for functional alternative splices in ESTs Genome Res. 12 2002 1837 1845
10. Pan, Q. et al. Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol. Cell (in press)