Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Biochemical Journal

Volumn 384, Issue 3, 2004, Pages 599-607

  Blume, Astrid ^a,d   Weidemann, Wenke ^a   Stelzl, Ulrich ^b   Wanker, Erich E ^b   Lucka, Lothar ^a   Donner, Peter ^c   Reutter, Werner ^a   Horstkorte, Rüdiger ^a   Hinderlich, Stephan ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c BAYER PHARMA AG   (Germany)

^d UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Deletion mutant; Domain; Sialic acid; UDP N acetylglucosamine 2 epimerase N acetylmannosamine kinase; Yeast two hybrid assay

Indexed keywords

AMINES; BIOSYNTHESIS; DIMERIZATION; FUNCTIONS; OLIGOMERS;

CELL-MATRIX; MUTANTS; NATIVE ENZYMES; TRIMERS;

ENZYMES;

COMPLEMENTARY DNA; EPIMERASE; SIALIC ACID; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE 2 EPIMERASE; URIDINE DIPHOSPHATE N ACETYLMANNOSAMINE KINASE;

ARTICLE; BACULOVIRUS; BIOSYNTHESIS; DELETION MUTANT; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; INSECT CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS RECOMBINANT; YEAST; YEAST TWO HYBRID ASSAY;

ANIMALS; CARBOHYDRATE EPIMERASES; CELL LINE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE DELETION; SIALIC ACIDS; SPODOPTERA; TWO-HYBRID SYSTEM TECHNIQUES;

DNA VIRUSES; ESCHERICHIA COLI; INSECTA; MAMMALIA; NEGIBACTERIA; UNIDENTIFIED BACULOVIRUS;

EID: 10944220454     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040917     Document Type: Article

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