Q TRAP ™mass spectrometer technology for proteomics applications

Drug Discovery Today: TARGETS

Volumn 3, Issue 2 SUPPL.1, 2004, Pages

  Hager, James W ^a  

^a MDS SCIEX   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; AMINO ACID SEQUENCE; AUTOMATION; DEVICE; MASS SPECTROMETER; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEOMICS; REPRODUCIBILITY; REVIEW;

EID: 10844296806     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1741-8372(04)02421-1     Document Type: Review

References (22)

1. Mann, M. et al. (2001) Analysis of proteins and proteomes by mass spectrometry. Annu. Rev. Biochem. 70, 437-473
2. Smith, R.D. (2002) Trends in mass spectrometry instrumentation for proteomics. Trends Biotechnol. 12, S3-S7
3. Aebersold, R. and Mann, M. (2003) Mass spectrometry-based proteomics. Nature 422, 198-207
4. Fenn, J.B. et al. (1989) Electrospray ionization mass spectrometry of large biomolecules. Science 246, 64-71
5. Karas, M. and Hillenkamp, F. (1988) Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem. 60, 2299-2302
6. Hager, J.W. (2002) A new linear ion trap mass spectrometer. Rapid Commun. Mass Spectrom. 16, 512-526
7. linear ion trap (QTRAP™) mass spectrometer. Rapid. Commun. Mass Spectrom. 17, 1056-1064
8. Johnson, J.V. et al. (1990) Tandem-in-space and tandem-in-time mass spectrometry: triple quadrupoles and quadrupole ion traps. Anal. Chem. 62, 2162-2172
9. Zweigenbaum, J. et al. (1999) High-throughput bioanalytical LC/ MS/ MS determination of benzodiazepines in human urine: 1000 samples per 12 hours. Anal. Chem. 71, 2294-2300
10. Schwartz, J.C. et al. (1990) Systematic delineation of scan modes in multidimensional mass spectrometry. Anal. Chem. 62, 1809-1818
11. Wilm, M. et al. (1996) Parent ion scans of unseparated peptide mixtures. Anal. Chem. 68, 527-533
12. Annan, R.S. et al. (2001) A multidimensional electrospray MS-based approach to phosphopeptide mapping. Anal. Chem. 73, 393-404
13. Burlingame, A.L. et al. (1998) Mass spectrometry. Anal. Chem. 70, R647-R716
14. Zhang, Z. and McElvain, J.S. (2000) De novo peptide sequencing by two-dimensional fragment correlation mass spectrometry. Anal. Chem. 72, 2337-2350
15. Le Blanc, J.C.Y. et al. (2003) Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP™) used for high sensitivity proteomics applications. Proteomics 3, 859-869
16. Londry, F.L. and Hager, J.W. (2003) Mass selective axial ejection from a linear quadrupole ion trap. J. Am. Soc. Mass Spectrom. 14, 1130-1147
17. Hopfgartner, G. et al. (2003) Rapid screening and characterization of drug metabolites using a new quadrupole-linear ion trap mass spectrometer. J. Mass Spectrom. 38, 138-150
18. Collings, B.A. et al. (2003) Resonant excitation in a low-pressure linear ion trap. J. Am. Soc. Mass Spectrom. 14, 622-634
19. Chernushevich, I.V. et al. (2003) Charge state separation for protein applications using a quadrupole time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 17, 1416-1424
20. Tolmachev, A.V. et al. (2003) Suppression of the lower charge state ions in the external accumulation RF multipole with a reduced trapping DC potential. J. Am. Soc. Mass Spectrom. 14, 1229-1235
21. Hager, J.W. (2003) Product ion spectral simplification using time delayed fragment ion capture with tandem linear ion traps. Rapid Commun. Mass Spectrom. 17, 1389-1398
22. Schwartz, J.C. et al. (2002) A two-dimensional quadrupole ion trap mass spectrometer. J. Am. Soc. Mass Spectrom. 13, 659-669