Trimetazidine modified release in the treatment of stable angina: TRIUMPH Study

Clinical Drug Investigation

Volumn 24, Issue 12, 2004, Pages 731-738

  Makolkin, Vladimir I ^a   Osadchiy, Konstantin K ^a  

^a I M SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRATE; TRIMETAZIDINE;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; ATROPHIC GASTRITIS; CLINICAL TRIAL; CLONIC SEIZURE; CONTROLLED RELEASE FORMULATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HEART PALPITATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; OPEN STUDY; PATIENT SATISFACTION; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RASH; RUSSIAN FEDERATION; STABLE ANGINA PECTORIS; STATISTICAL ANALYSIS; TABLET; THORAX PAIN; VOMITING;

EID: 10844295057     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-200424120-00004     Document Type: Article

References (20)

1. International cardiovascular disease statistics. American Heart Association 2003. Available from URL: http://www.amencanheart.org/statistics/ index.html [Accessed 2004 November 2]
2. Peterson S, Rayner M. Coronary heart disease statistics 2002 ed. British Heart Foundation Health Promotion Research Group, Department of Public Health, Oxford, UK: 2002
3. Task force of the European Society of Cardiology. Management of stable angina. Eur Heart J 1997; 18: 394-413
4. Gibbons RJ, Abrams J, Chatterjee K, et al. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina - summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina). J Am Coll Cardiol 2003; 41: 159-68
5. Marzilli M, Klein WW. Efficacy and tolerability of trimetazidine in stable angina: a metaanalysis of randomized, double-blind, controlled trials. Coron Artery Dis 2003; 14: 171-9
6. Dalla-Volta S, Maraglino G, Della-Valentina P, et al. Comparison of trimetazidine with nifedipine in effort angina: a double-blind, crossover study. Cardiovasc Drugs Ther 1990; 4 Suppl. 4: 853-9
7. Detry JM, Sellier P, Pennaforte S, et al. Trimetazidine: a new concept in the treatment of angina: comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Br J Clin Pharmacol 1994; 37: 279-88
8. Manchanda SC, Krishnaswami S. Combination treatment with trimetazidine and diltiazem in stable angina pectoris. Heart 1997; 78: 353-7
9. Levy S. Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease. Group of South of France Investigators. Am J Cardiol 1995; 76: 12B-6B
10. Michaelides AP, Spiropoulos K, Dimopoulos K, et al. Antianginal efficacy of the combination of trimetazidine-propranolol compared with isosorbide dinitrate-propranolol in patients with stable angina. Clin Drug Invest 1997; 13: 8-14
11. Szwed H, Sadowski Z, Pachocki R, et al. Anti-ischaemic efficacy and tolerability of trimetazidine in elderly patients with angina. Clin Drug Invest 2000; 19: 1-8
12. Szwed H, Sadowski Z, Pachocki R, et al. The antiischemic effects and tolerability of trimetazidine in coronary diabetic patients: a substudy from TRIMPOL 1. Cardiovasc Drugs Ther 1999; 13: 217-22
13. Szwed H, Sadowski Z, Pachocki R, et al. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Eur Heart J 2001; 22: 2267-74
14. Sellier P, Broustet JP. Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study. Am J Cardiovasc Drugs 2003; 3: 361-9
15. Barre J, Ledudal P, Oosterhuis B, et al. Pharmacokinetic profile of a modified release formulation of trimetazidine (TMZ MR 35mg) in the elderly and patients with renal failure. Biopharm Drug Dispos 2003; 24: 159-64
16. Spertus JA, Winder JA, Dewhurst TA, et al. Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery disease. J Am Coll Cardiol 1995; 25: 333-41
17. Dougherty CM, Dewhurst T, Nichol WP, et al. Comparison of three quality of life instruments in stable angina pectoris: Seattle Angina Questionnaire, Short Form Health Survey (SF-36), and Quality of Life Index-Cardiac Version III. J Clin Epidemiol 1998; 51: 569-75
18. Campeau L. Grading of angina pectoris [letter]. Circulation 1976; 54: 522-3
19. Willich SN. European survey on circadian variation of angina pectoris (ESCVA): design and preliminary results. J Cardiovasc Pharmacol 1999; 34 Suppl. 2: S9-S13
20. Genissel P, Chodjania Y, Delmolis JL, et al. Assessment of the sustained release properties of a new oral formulation of trimetazidine in pigs and dogs and confirmation in healthy human volunteers. Eur J Drug Metabol Pharmacokin 2004; 29 (1): 61-8