Pulmonary hemorrhage after rhDNase treatment in a preterm infant with chronic lung disease

International Pediatrics

Volumn 19, Issue 4, 2004, Pages 234-236

  Tatli, M Mansur ^a,b   Kumral, Abdullah ^a   Duman, Nuray ^a   Yesilirmak, Didem ^a   Özkan, Hasan ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Chronic lung disease; Preterm; Pulmonary hemorrhage; rhDNase

Indexed keywords

DORNASE ALFA;

AIRWAY OBSTRUCTION; ARTICLE; CASE REPORT; CHRONIC LUNG DISEASE; CYSTIC FIBROSIS; DNA CONTENT; ENZYME THERAPY; FEMALE; HEMOPTYSIS; HUMAN; LUNG FLUID; LUNG HEMORRHAGE; MUCOUS CELL; MUCUS SECRETION; NEWBORN; NEWBORN INTENSIVE CARE; PREMATURITY; STANDARD; VISCOELASTICITY;

EID: 10844266607     PISSN: 08856265     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Abman SH, Groothius JR. Pathophysiology and treatment of bronchopulmonary dysplasia. Pediatric Clinics of North America 1994;41:277-313.
2. Merkus PJ, de Hoog M, van Gent R, de Jongste JC. DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. Eur Respir J 2001;18:734-7.
3. Durward A, Forte V, Shemie SD. Resolution of mucus plugging and atelectasis after intratracheal rhDNase therapy in a mechanically ventilated child with refractory status asthmaticus. Crit Care Med 2000;28:560-2.
4. Quan JM, Tiddens HA, Sy JP, et al. A two-year randomized, placebo-controlled trial of dornase alfa in young patients with cystic fibrosis with mild lung function abnormalities. J Pediatr 2001;139:813-20.
5. Puchelle E, Zahm JM, de Bentzmann S, et al. Effects of rhDNase on purulent airway secretions in chronic bronchitis. Eur Respir J 1996;9:765-9.
6. Kearney CE, Wallis CE. Deoxyribonuclease for cystic fibrosis. Cochrane Database Syst Rev 2000;2.
7. El Hassan NO, Chess PR, Huysman MW, Merkus PJ, de Jongste JC. Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates. Pediatrics 2001;108:468-70.
8. Shah PL, Scott SF, Knight RA, Hodson ME. The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis. Eur Respir J 1996;9:531-4.
9. Rochat T, Pastore FD, Schlegel-Haueter SE, et al. Aerosolized rhDNase in cystic fibrosis: effect on leucocyte proteases in sputum. Eur Respir J 1996;9:2200-6.
10. Cantin AM. DNase I acutely increases cystic fibrosis sputum elastase activity and its potential to induce lung hemorrhage in mice. Am J Respir Crit Care Med 1998;157:464-9.