An anionic polycondensation strategy for the synthesis of dibenzoxanthenones: Progress toward the synthesis of hypoxyxylerone

Synlett

Volumn , Issue 15, 2004, Pages 2693-2696

  Chevenier, Emmanuel ^a   Lucatelli, Christophe ^a   Pandya, Urvish ^a   Wang, Wei ^a   Gimbert, Yves ^a   Greene, Andrew E ^a  

^a UNIV GRENOBLE ALPES   (France)

Author keywords

Antitumor agents; Condensation; Heterocycles; Natural products; Total synthesis

Indexed keywords

DIBENZOXANTHENONE; HYPOXYXYLERONE; NATURAL PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; METHODOLOGY; POLYMERIZATION; REACTION ANALYSIS;

EID: 10844259734     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-835634     Document Type: Article

References (28)

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23. 16c could be prepared through a route analogous to that used for the preparation of acetonaphthone 15b (Scheme 5, N-methoxy-N-methylacetamide replaces 12); however, a route analogous to that used for 17a proved superior (Scheme 8, R = OMe; 52% overall yield).
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28. 2 = H, OH) could also be secured in moderate yield through treatment of the xanthones 18b-d with boron tribromide prior to reduction-hydrolysis.