Normal functional protein S activity does not exclude protein S deficiency

Pathophysiology of Haemostasis and Thrombosis

Volumn 33, Issue 4, 2003, Pages 202-205

  Rodger, Marc A ^a,b,c   Carrier, Marc ^a   Gervais, Muriel ^a   Rock, Gail ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Laboratory diagnosis; Protein S deficiency; Screening

Indexed keywords

PROTEIN S;

ACCURACY; ARTICLE; BIOASSAY; CONTROLLED STUDY; FUNCTION TEST; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN S DEFICIENCY;

ACTIVATED PROTEIN C RESISTANCE; DIAGNOSTIC ERRORS; FALSE POSITIVE REACTIONS; HUMANS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROTEIN C; PROTEIN S; PROTEIN S DEFICIENCY; SENSITIVITY AND SPECIFICITY;

EID: 10844241409     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081509     Document Type: Article

References (18)

1. Fair DS, Marlar RA: Biosynthesis and secretion of factor VII, protein C, protein S, and the protein C inhibitor from a human hepatoma cell line. Blood 1986; 67: 64-70.
2. Watkins PC, Eddy R, Fukushima Y, Byers MG, Cohen EH, Dackowski WR, Wydro RM, Shows TB: The gene for protein S maps near the centromere of human chromosome 3. Blood 1988; 71: 238-241.
3. Dahlback B, Frohm B, Nelsestuen G: High affinity interaction between C4b-binding protein and vitamin K-dependent protein S in the presence of calcium. Suggestion of a third component in blood regulating the interaction. J Biol Chem 1990; 265: 16082-16087.
4. Dykes AC, Walker ID, McMahon AD, Islam SI, Tait RC: A study of protein S antigen levels in 3,788 healthy volunteers: Influence of age, sex and hormone use, and estimate for prevalence of deficiency state. Br J Haematol 2001; 113: 636-641.
5. Sanson BJ, Simioni P, Tormene D, Moia M, Friederich PW, Huisman MV, Prandoni P, Bura A, Rejto L, Wells PS, Mannucci PM, Girolami A, Buller HR, Prins MH: The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C or protein S: A prospective cohort study. Blood 1999; 94: 3702-3706.
6. Bucciarelli P, Rosendaal FR, Tripodi A, Mannucci PM, De Stefano V, Palareti G, Finazzi G, Baudo F, Quintavalla R: Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S defi ciency, or activated protein C resistance: A multicenter collaborative family study. Arterioscler Thromb Vasc Biol 1999; 19: 1026-1033.
7. Simioni P, Sanson BJ, Prandoni P, Tormene D, Friederich PW, Girolami B, Gavasso S, Huisman MV, Buller HR, ten Cate JW, Girolami A, Prins MH: Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost 1999; 81: 198-202.
8. Gandrille S, Borgel D, Sala N, Espinosa-Parrilla Y, Simmonds R, Rezende S, Lind B, Mannhalter C, Pabinger I, Reitsma PH, Formstone C, Cooper DN, Saito H, Suzuki K, Bernardi F, Aiach M: Protein S deficiency: A database of mutations - Summary of the first update. Thromb Haemost 2000; 84: 918.
9. Gandrille S, Borgel D, Ireland H, Lane DA, Simmonds R, Reitsma PH, Mannhalter C, Pabinger I, Saito H, Suzuki K, Formstone C, Cooper DN, Espinosa Y, Sala N, Bernardi F, Aiach M: Protein S deficiency: A database of mutations. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 1997; 77: 1201-1214.
10. Makris M, Leach M, Beauchamp NJ, Daly ME, Cooper PC, Hampton KK, Bayliss P, Peake IR, Miller GJ, Preston FE: Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis, in families with inherited deficiencies of protein S. Blood 2000; 95: 1935-1941.
11. Simmonds RE, Ireland H, Lane DA, Zoller B, de Frutos PG, Dahlback B: Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect. Ann Intern Med 1998; 128: 8-14.
12. D'Angelo A, Vigano-D'Angelo S, Esmon CT, Comp PC: Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation. J Clin Invest 1988; 81: 1445-1454.
13. Reiter W, Ehrensberger H, Steinbruckner B, Keller F: Parameters of haemostasis during acute venous thrombosis. Thromb Haemost 1995; 74: 596-601.
14. Clark P, Brennand J, Conkie JA, McCall F, Greer IA, Walker ID: Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Haemost 1998; 79: 1166-1170.
15. Faioni EM, Franchi F, Asti D, Sacchi E, Bernardi F, Mannucci PM: Resistance to activated protein in nine thrombophilic families: Interference in a protein S functional assay. Thromb Haemost 1993; 70: 1067-1071.
16. Siegert G, Schellong S, Knoefler R, Jaross W: Low molecular weight heparin: A possible cause for higher protein S activity than free protein S concentration. Blood Coagul Fibrinolysis 2000; 11: 747-754.
17. Persson KEM, Hillarp A, Dahlback B: Analytical considerations for free protein S assays in protein S defi ciency. Thromb Haemost 2001; 86: 1144-1147.
18. Lawrie AS, Lloyd ME, Mohamed F, Irons S, Hughes GR, Savidge GF: Assay of protein S in systemic lupus erythematosus. Blood Coagul Fibrinolysis 1995; 6: 322-324.