Black tea extract reduces the oral toxicity of botulinum neurotoxin applied to food

Nippon Shokuhin Kagaku Kogaku Kaishi

Volumn 49, Issue 12, 2002, Pages 808-812

  Sawamura, Shin Ichi ^a   Sakane, Iwao ^a   Satoh, Eiki ^b   Ishii, Toshiaki ^b   Shimizu, Yoshio ^b   Nishimura, Masakazu ^b  

^a 421 0516   (Japan)

^b OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAMELLIA SINENSIS; CLOSTRIDIUM; CLOSTRIDIUM BOTULINUM; MAMMALIA;

EID: 10844227478     PISSN: 1341027X     EISSN: None     Source Type: Journal    
DOI: 10.3136/nskkk.49.808     Document Type: Article

References (8)

1. Simpson, L.L., Molecular pharmacology of botulinum toxin and tetanus toxin. Ann. Rev. Pharmacol. Toxicol., 26, 427-453 (1986).
2. Deshpande, S.S., Sheridan, R.E. and Adler, M., Efficacy of certain quinolines as pharmacological antagonists in botulinum neurotoxin poisoning. Toxicon. 35, 433-445 (1997).
3. Simpson, L.L., Use of pharmacologic antagonists to deduce commonalities of biologic activity among Clostridial neurotoxins. J. Pharmacol. Exp. Ther 245, 867-872 (1988).
4. Satoh, E., Ishii, T., Shimizu, Y., Sawamura, S. and Nishimura, M., Black tea extract, thearubigin fraction, counteract the effects of botulinum neurotoxins in mice. Br. J. Pharmacol. 132, 797-798 (2001).
5. Satoh, E., Ishii, T., Shimizu, Y., Sawamura, S. and Nishimura, M. , The mechanism underlying the protective effect of the thearubigin fraction of black tea (Camellia sinensis) extract against the neuromuscular blocking action of botulinum neurotoxins. Pharmacol. Toxicol. 90, 199-202 (2002).
6. Satoh, E., Ishii, T., Shimizu, Y., Sawamura, S. and Nishimura, M., Black tea extract, thearubigin fraction, counteracts the effect of tetanus toxin in mice. Exp. Biol. Med. 226, 577-580 (2001).
7. Xie, B., Shi, H., Chen, Q. and Ho, CT., Antioxidant properties of fractions and polyphenol constituents from green, oolong and black teas. Proc. Natl. Sci. Counc. Repub. China B. 17, 77-84 (1993).
8. Figgitt, D.P. and Noble, S., Botulinum Toxin B : A review of its therapeutic potential in the management of cervical dystonia. Drugs 62, 705-722 (2002).