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Volumn 13, Issue 19, 2003, Pages 3277-3280

Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; DOPAMINE UPTAKE INHIBITOR; NORADRENALIN UPTAKE INHIBITOR; NORBORNANE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR;

EID: 10744233215     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00660-7     Document Type: Article
Times cited : (19)

References (29)
  • 3
    • 0001053316 scopus 로고
    • Drugs and the treatment of psychiatic disorders
    • Goodman, A. G., Gilman L. S., Rall, T. W., Murad, F., Eds.; Macmillan: New York
    • Baldessarini, R. J. Drugs and the Treatment of Psychiatic Disorders. In The Pharmacological Basis of Therapeutics, 7th ed.; Goodman, A. G., Gilman L. S., Rall, T. W., Murad, F., Eds.; Macmillan: New York, 1985, p 416.
    • (1985) The Pharmacological Basis of Therapeutics, 7th Ed. , pp. 416
    • Baldessarini, R.J.1
  • 10
    • 85031074553 scopus 로고    scopus 로고
    • i (nM): 5HT <5, DA<20 and NE<50. Catalyst™, version 4.5 (Accelerys, San Diego, CA, USA). Common feature approach generated within Catalyst, using BEST with an energy limit at 10 Kcal/mol, default dictionary definition, feature spacing set to 150 picometer with variable weight and tolerance.
  • 15
    • 85031078620 scopus 로고    scopus 로고
    • 1H (ppm) δ 6.05 (d, 2H), 6.50 (d, 2H), ratio 79:21. The major isomer was confirmed as endo by nOe: interactions are observed between the bridgehead proton and the aromatic ring; such an interaction is not observed for the exo isomer.
  • 16
    • 85031070683 scopus 로고    scopus 로고
    • r (E2) 22.2 min. Analytical column size: 250×4.6 mm 1D and for preparative work: 250×20 mm 1D.
  • 19
    • 85031080583 scopus 로고    scopus 로고
    • r (E2) 40.89 min. Absolute stereochemistry not assigned. Absolute stereochemistry was assigned later by X-ray crystallographic analysis of Ar=naphthyl, 16 d.
  • 22
    • 85031081276 scopus 로고    scopus 로고
    • r (E2) 15.21 min.
  • 23
    • 85031072675 scopus 로고    scopus 로고
    • 2NH) HPLC/MS profiling.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.