Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil

European Journal of Clinical Pharmacology

Volumn 59, Issue 7, 2003, Pages 553-557

  McGready, R ^a,b,c   Stepniewska, K ^b,c   Seaton, E ^a   Cho, T ^a   Cho, D ^a   Ginsberg, A ^a   Edstein, M D ^d   Ashley, E ^a,b,c   Looareesuwan, S ^b   White, N J ^b,c   Nosten, F ^a,b,c  

^a SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

Cycloguanil; Hormonal therapy; Oral contraceptive; Pregnancy; Proguanil

Indexed keywords

CYCLOGUANIL; CYTOCHROME P450 2C19; ETHINYLESTRADIOL PLUS LEVONORGESTREL; ORAL CONTRACEPTIVE AGENT; PROGUANIL;

AREA UNDER THE CURVE; ARTICLE; BIRTH CONTROL; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DELIVERY; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HORMONAL THERAPY; HUMAN; MALARIA; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; SIDE EFFECT; SINGLE DRUG DOSE; THAILAND; THIRD TRIMESTER PREGNANCY; URINALYSIS;

ANTIMALARIALS; BIOTRANSFORMATION; CASE-CONTROL STUDIES; CHLOROGUANIDE; COHORT STUDIES; CONTRACEPTIVES, ORAL, HORMONAL; FEMALE; HUMANS; MALARIA, FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PREGNANCY TRIMESTER, THIRD; THAILAND; TRIAZINES;

EID: 10744230915     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-003-0651-x     Document Type: Article

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