Spleen transplantation in miniature swine: Surgical technique and results in major histocompatibility complex-matched donor and recipient pairs

Transplantation

Volumn 75, Issue 11, 2003, Pages 1799-1806

  Gollackner, B ^a   Dor, F J M F ^a   Knosalla, C ^a   Buhler, L ^a   Duggan, M ^a   Huang, C A ^a   Houser, S L ^a   Sachs, D H ^a   Kawai, T ^a   Ko, D S C ^a   Cooper, D K C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMERA; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTER; GRAFT VERSUS HOST REACTION; HLA MATCHING; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; ORGAN DONOR; OUTCOMES RESEARCH; PORTAL VEIN; PRIORITY JOURNAL; RECIPIENT; SPLEEN TRANSPLANTATION; SURGICAL TECHNIQUE; SWINE; XENOGRAFT;

ANIMALS; BIOPSY; CYCLOSPORINE; FLOW CYTOMETRY; GRAFT REJECTION; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY TESTING; IMMUNOSUPPRESSIVE AGENTS; MAJOR HISTOCOMPATIBILITY COMPLEX; POSTOPERATIVE COMPLICATIONS; SKIN TRANSPLANTATION; SPLEEN; SPLENECTOMY; SWINE, MINIATURE; TISSUE DONORS; TRANSPLANTATION CHIMERA;

EID: 10744230215     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000063220.19441.5C     Document Type: Article

References (17)

1. Dor FJMF, Gollackner B, Cooper DKC. Can spleen transplantation induce tolerance? A review of the literature. In press.
2. Sachs DH. MHC homozygous miniature swine, In: Swindle MM, Moody DC, Phillips LD, eds. Swine as models in biomedical research. Ames, IA: Iowa State University Press 1992, pp 3-15.
3. Fuchimoto Y, Huang CA, Shimizu A, et al. An allelic non-histocompatibility antigen with wide tissue distribution as a marker for chimerism in pigs. Tissue Antigens 1999; 54: 43-52.
4. Leight GS, Kirkman R, Rasmusen BA, et al. Transplantation in miniature swine. III. Effects of MSLA and A-O blood group matching on skin allograft survival. Tissue Antigens 1978; 12: 65-74.
5. Fuchimoto Y, Huang CA, Yamada K, et al. Mixed chimerism and tolerance without whole body irradiation in a large animal model. J Clin Invest 2000; 105: 1779-1789.
6. Yamada K, Shimizu A, Ierino FL, et al. Thymic transplantation in miniature swine. I. Development and function of the "thymokidney." Transplantation 1999; 68: 1684-1692.
7. Fuchimoto Y, Yamada K, Shimizu A, et al. Relationship between chimerism and tolerance in a kidney transplantation model. J Immunol 1999; 162: 5704-5711.
8. Carrel A. Remote results of replantation of kidney and spleen. J Exp Med 1910; 12: 126-50.
9. Hofmann GO, Land W, Weiss EP, et al. Spleen transplantation in the dog as a model for studying immunological feedback reactions. Eur Surg Res 1984; 16: 40-46.
10. Moore FD, Wheeler HB, Demissianos HV, et al. Experimental whole-organ transplantation of the liver and of the spleen. Ann Surg 1960; 152: 374-387.
11. Wheeler HB, Balankura O, Pendower JEH, et al. The homograft response to whole-organ transplantation of the canine spleen. J Surg Res 1962; 2: 114-123.
12. Jordan GL, Fiscus WG, Trentin JJ, et al. Splenic transplantation in the dog. Ann N Y Acad Sci 1964; 120: 612-625.
13. Picker LJ, Siegelman MH. Lymphoid tissues and organs. In: Paul WE, ed. Fundamental immunology. New York: Lippincott-Raven, 1999, pp 479-531.
14. Huang CA, Fuchimoto Y, Scheier-Dolberg R, et al. Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large animal model. J Clin Invest 2000; 105: 173-181.
15. Rosengard BR, Ojikutu CA, Fishbein J, et al. Selective breeding of miniature swine leads to an increased rate of acceptance of MHC-identical, but not of class I-disparate, renal allografts. J Immunol 1992; 149: 1099-1103.
16. Lunney JK, Sachs DH. The swine leukocyte antigen (SLA) complex. In: Bach FH, Auchincloss H Jr, eds. Transplantation immunology. New York: Wiley, 1995, pp 339-345.
17. Fuchimoto Y, Gleit Z, Huang CA, et al. Skin-specific alloantigens in miniature swine. Transplantation 2001; 72: 122-126.