Design, synthesis and biological activity of novel dimethyl-{2-[6- substituted-indol-1-yl]-ethyl}-amine as potent, selective, and orally-Bioavailable 5-HT1D agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 24, 2003, Pages 4409-4413

  Isaac, Methvin ^a   Slassi, Malik ^a   Xin, Tao ^a   Arora, Jalaj ^a   O'Brien, Anne ^a   Edwards, Louise ^a   MacLean, Neil ^a   Wilson, Julie ^a   Demschyshyn, Lidia ^a   Labrie, Phillipe ^a   Naismith, Angela ^a   Maddaford, Shawn ^a   Papac, Damon ^b   Harrison, Shuree ^b   Wang, Hua ^b   Draper, Stan ^b   Tehim, Ashok ^a  

^a NPS Pharmaceuticals Inc   (Canada)

^b NPS Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [1 (2 DIMETHYLAMINOETHYL) 1H INDOL 6 YL]TETRAHYDROTHIOPYRAN 4 OL; INDOLE DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN 1D AGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 10744230198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.09.025     Document Type: Article

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