Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

Journal of Medicinal Chemistry

Volumn 46, Issue 25, 2003, Pages 5294-5297

  Barrow, James C ^a   Nantermet, Philippe G ^a   Stauffer, Shaun R ^a   Ngo, Phung L ^a   Steinbeiser, Melissa A ^a   Mao, Shi Shan ^a   Carroll, Steven S ^a   Bailey, Carolyn ^a   Colussi, Dennis ^a   Bosserman, Michelle ^a   Burlein, Christine ^a   Cook, Jacquelynn J ^a   Sitko, Gary ^a   Tiller, Philip R ^a   Miller Stein, Cynthia M ^a   Rose, Mark ^a   McMasters, Daniel R ^a   Vacca, Joseph P ^a   Selnick, Harold G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ARGININE CARBOXYPEPTIDASE; CARBOXYPEPTIDASE; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE B; CARBOXYPEPTIDASE M; IMIDAZOLEACETIC ACID INHIBITOR; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; FIBRINOLYSIS; FIBRINOLYTIC THERAPY; IN VITRO STUDY; NONHUMAN; PRIMATE; RAT; STRUCTURE ANALYSIS; THROMBOSIS;

ACETIC ACIDS; AMINOPYRIDINES; ANIMALS; BINDING SITES; CARBOXYPEPTIDASE U; DOGS; FIBRINOLYTIC AGENTS; HUMANS; IMIDAZOLES; MICROSOMES; MODELS, MOLECULAR; PROPIONIC ACIDS; PROTEASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10744228937     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034141y     Document Type: Article

References (33)

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