Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants

Protein Engineering

Volumn 16, Issue 6, 2003, Pages 391-396

  Guo, Qing ^a,c   Zhou, Weihong ^a   Too, Hiu Mei ^b   Li, Jianhui ^c   Liu, Yiwei ^a   Bartlam, Mark ^a   Dong, Yicheng ^a,c   Wong, Kam Bo ^b   Shaw, Pang Chui ^b   Rao, Zihe ^a,c  

^a TSINGHUA UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Complex structure; Mutants; N glycosidase mechanism; Ribosome inactivating protein; Trichosanthin

Indexed keywords

ADENINE; ADENOSINE PHOSPHATE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GLYCOSIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRICHOSANTHIN;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENETICS; HUMAN; IMMUNOMODULATION; METABOLISM; METHODOLOGY; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 10744226691     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/gzg056     Document Type: Article

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