Acute hepatitis C virus seroconversion in a Scottish blood donor: HCV antigen is not comparable with HCV nucleic acid amplification technology screening

Vox Sanguinis

Volumn 86, Issue 1, 2004, Pages 15-20

  Dow, Brian C ^a   Munro, H ^a   Buchanan, I ^a   Ferguson, K ^a   Davidson, F ^a   Lycett, C ^a   Jarvis, M ^a   Cleland, A ^a   Petrik, J ^a   Lumley, S ^a   MacLean, A ^b  

^a SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

^b Western Isles Hospital   (United Kingdom)

Author keywords

Blood donor; HCV; NAT

Indexed keywords

HEPATITIS C ANTIGEN; NUCLEIC ACID; VIRUS RNA;

ANTIGEN DETECTION; ARTICLE; BLOOD DONOR; CHEMOLUMINESCENCE; CONTROLLED STUDY; DISEASE MARKER; ELECTROIMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOREACTIVITY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; NUCLEIC ACID AMPLIFICATION; PRIORITY JOURNAL; RNA ISOLATION; SCREENING TEST; SEROCONVERSION; VALIDATION PROCESS; VIRUS DETECTION;

ACUTE DISEASE; ANTIGENS, VIRAL; BLOOD DONORS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; RNA, VIRAL; SCOTLAND; SEROLOGIC TESTS;

EID: 10744226645     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0042-9007.2004.00387.x     Document Type: Article

References (15)

1. Jarvis LM, Simmonds P: Scottish experience with NAT. Transfus Med 2002; 12:259-264
2. Cleland A, Nettleton P, Jarvis LM, Simmonds P: Use of bovine viral diarrhoea virus as an internal control for amplification of hepatitis C virus. Vox Sang 1999; 76:170-174
3. Davidson F, Simmonds P, Ferguson JC, Jarvis LM, Dow BC, Follett EAC, Seed CRG, Krusius T, Lin C, Medgyesi GA, Kiyokawa H, Olim G, Duiraisamy G, Cuypers T, Saeed AA, Teo D, Conradie J, Kew MC, Lin M, Nachaprayoon C, Ndimbie OK, Yap PL: Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5′ non-coding region. J Gen Virol 1995; 76:1197-1204
4. Simmonds P, Kurtz J, Tedder RS: The UK blood transfusion service: over a (patent) barrel. Lancet 2002; 359:1713-1714
5. Loubiere S, Rotily M, Durand-Zaleski I, Costagliola D: Including polymerase chain reaction in screening for hepatitis C virus RNA in blood donations is not cost-effective. Vox Sang 2001; 80:199-204
6. Jackson BR, Busch MP, Stramer SL, AuBuchon JP: The cost-effectiveness of NAT for HIV, HCV, and HBV in whole-blood donations. Transfusion 2003; 43:721-729
7. Galel SA, Strong DM, Tegtmeier GE, Holland PV, Kuramoto IK, Kemper M, Pietrelli L, Gallarda J: Comparative yield of HCV RNA testing in blood donors screened by 2.0 versus 3.0 antibody assays. Transfusion 2002; 42:1507-1513
8. Hyland C, Seed CR, Kiely P, Parker S, Cowley N, Bolton W: Follow-up of six blood donors highlights the complementary role and limitations of hepatitis C virus antibody and nucleic acid amplification tests. Vax Sang 2003; 85:1-8
9. Peterson J, Green G, Iida K, Caldwell B, Kerrison P, Bernich S, Aoyagi K, Lee SR: Detection of hepatitis C core antigen in the antibody negative 'window' phase of hepatitis C infection. Vox Sang 2000; 78:80-85
10. Courouce AM, Le Marrec N, Boucherdeau F, Razer A, Maniez M, Laperche S, Simon N: Efficacy of HCV core antigen detection during the preseroconversion period. Transfusion 2000; 40: 1198-1202
11. Lee SR, Peterson J, Niven P, Bahl C, Page E, DeLeys R, Giordano-Schmidt D, Baggett D, Green G: Efficacy of a hepatitis C virus core antigen enzyme-linked immunosorbent assay for the identification of 'window-phase' blood donations. Vox Sang 2001; 80:19-23
12. Nübling CM, Unger G, Chudy M, Raia S, Lüwer J: Sensitivity of HCV core antigen and HCV RNA detection in the early infection phase. Transfusion 2002; 42:1037-1045
13. Grant PR, Sims CM, Tedder RS: Quantification of HCV RNA levels and detection of core antigen in donations before seroconversion. Transfusion 2002; 42:1032-1036
14. Laperche S, Le Marrec N, Simon N, Bouchardeau F, Defer C, Maniez-Montreuil M, Levayer T, Zappitelli JP, Lefrere JJ: A new HCV core antigen assay based on disassociation of immune complexes: an alternative to molecular biology in the diagnosis of early HCV infection. Transfusion 2003; 43:958-962
15. Fang CT, Tobler LH, Haesche C, Busch MP, Phelps B, Leparc G: Fluctuation of HCV viral load before seroconversion in a healthy volunteer blood donor. Transfusion 2003; 43:541-544