Role of lactate in the brain energy metabolism: Revealed by Bioradiography

Neuroscience Research

Volumn 48, Issue 1, 2004, Pages 13-20

  Tanaka, Masaaki ^a   Nakamura, Fusao ^a   Mizokawa, Shigekazu ^a   Matsumura, Akira ^a   Matsumura, Kiyoshi ^b   Murata, Tetsuhito ^c   Shigematsu, Makoto ^a   Kageyama, Katsuhiro ^a   Ochi, Hironobu ^a   Watanabe, Yasuyoshi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

Brain slice; Energy metabolism; Glucose; Lactate; 18F FDG

Indexed keywords

ALPHA CYANO 4 HYDROXYCINNAMIC ACID; FLUORODEOXYGLUCOSE F 18; GLUCOSE; LACTIC ACID; RINGER SOLUTION;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; BRAIN RADIOGRAPHY; BRAIN SLICE; CONTROLLED STUDY; ENERGY METABOLISM; INCUBATION TIME; MALE; NONHUMAN; OXYGENATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT;

EID: 10744226163     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2003.09.001     Document Type: Article

References (29)

1. Bishop M.J., Everse J., Kaplan N.O. Identification of lactate dehydrogenase isoenzymes by rapid kinetics. Proc. Natl. Acad. Sci. U.S.A. 69:1972;1761-1765.
2. 11C ]pyruvic acid, via an enzymatic route Appl. Radiat. Isot. 39:1988;627-630.
3. Cox D.W., Drower J., Bachelard H.S. Effects of metabolic inhibitors on evoked activity and the energy state of hippocampal slices superfused in vitro. Exp. Brain Res. 57:1985;464-470.
4. Dringen R., Wiesinger H., Hamprecht B. Uptake of L-lactate by cultured rat brain neurons. Neurosci. Lett. 163:1993;5-7.
5. 1. J. Biol. Chem. 270:1995;1843-1849.
6. Gehardt Hansen W. Lactate dehydrogenase isoenzymes in the central nervous system. Dan. Med. Bull. 15:1968;111-112.
7. Halestrap A.P. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem. J. 148:1975;85-96.
8. Halestrap A.P., Denton R.M. Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate. Biochem. J. 138:1974;313-316.
9. 18F ]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution J. Nucl. Med. 27:1986;235-238.
10. Ignacio P.C., Baldwin B.A., Vijayan V.K., Tait R.C., Gorin F.A. Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system. Brain Res. 529:1990;42-49.
11. Izumi Y., Benz A.M., Katsuki H., Zorumski C.F. Endogenous monocarboxylates sustain hippocampal synaptic function and morphological integrity during energy deprivation. J. Neurosci. 17:1981;9448-9457.
12. Kato K., Shimizu A., Kurobe N., Takashi M., Koshikawa T. Human brain-type glycogen phosphorylase: quantitative localization in human tissues determined with an immunoassay system. J. Neurochem. 52:1989;1425-1432.
13. Li X., Yokono K., Okada Y. Phosphofructokinase, a glycolytic regulatory enzyme has a crucial role for maintenance of synaptic activity in guinea pig hippocampal slices. Neurosci. Lett. 294:2000;81-84.
14. Lucignani G., Schmidt K.C., Moresco R.M., Striano G., Colombo F., Sokoloff L., Fazio F. Measurement of regional cerebral glucose utilization with fluorine-18-FDG and PET in heterogeneous tissues: theoretical considerations and practical procedure. J. Nucl. Med. 34:1993;360-369.
15. Maran A., Cranston I., Lomas J., Macdonald I., Amiel S.A. Protection by lactate of cerebral function during hypoglycaemia. Lancet. 343:1994;16-20.
16. Matsumura K., Bergström M., Onoe H., Takechi H., Westerberg G., Antoni G., Bjurling P., Jacobson G.B., Långström B., Watanabe Y. In vitro positron emission tomography (PET): use of positron emission tracers in functional imaging in living brain slices. Neurosci. Res. 22:1995;219-229.
17. Murata T., Waki A., Omata N., Fujibayashi Y., Sadato N., Yano R., Yoshimoto M., Isaki K., Yonekura Y. Dynamic changes in glucose metabolism by lactate loading as revealed by a positron autoradiography technique using rat living brain slices. Neurosci. Lett. 249:1998;155-158.
18. Murata T., Omata N., Fujibayashi Y., Waki A., Sadato N., Yoshimoto M., Omori M., Isaki K., Yonekura Y. Dynamic changes in glucose metabolism induced by thiamine deficiency and its replenishment as revealed by a positron autoradiography technique using rat living brain slices. J. Neurol. Sci. 164:1999;29-36.
19. Nedergaard M., Goldman S.A. Carrier-mediated transport of lactic acid in cultured neurons and astrocytes. Am. J. Physiol. 265:1993;282-289.
20. Omata N., Murata T., Fujibayashi Y., Waki A., Sadato N., Yoshimoto M., Wada Y., Yonekura Y. Hypoxic but not ischemic neurotoxicity of free radicals revealed by dynamic changes in glucose metabolism of fresh rat brain slices on positron autoradiography. J. Cereb. Blood Flow Metab. 20:2000;350-358.
21. Patlak C.S., Blasberg R.G., Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metab. 3:1983;1-7.
22. 18F ]fluoro-2-deoxy-D-glucose: validation of method Ann. Neurol. 6:1979;371-388.
23. Rosenberg P.A., Dichter M.A. Glycogen accumulation in rat cerebral cortex in dissociated cell culture. J. Neurosci. Methods. 15:1985;101-112.
24. Sakurai T., Yang B., Takata T., Yokono K. Synaptic adaptation to repeated hypoglycemia depends on the utilization of monocarboxylates in guinea pig hippocampal slices. Diabetes. 51:2002;430-438.
25. Schurr A., West C.A., Rigor B.M. Lactate-supported synaptic function in the rat hippocampal slice preparation. Science. 240:1988;1326-1328.
26. Swanson R.A. Physiologic coupling of glial glycogen metabolism to neuronal activity in brain. Can. J. Physiol. Pharmacol. 70:1992;138-144.
27. Tsacopoulos M., Magistretti P.J. Metabolic coupling between glia and neurons. J. Neurosci. 16:1996;877-885.
28. 13C nuclear magnetic resonance spectroscopy. J. Cereb. Blood Flow Metab. 18:1998;109-117.
29. Williams R.J., Maus M., Stella N., Glowinski J., Premont J. Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons. Neuroscience. 74:1996;461-468.