Significant dominance of fibrinogen over immunoglobulins, C-reactive protein, cholesterol and triglycerides in maintaining increased red blood cell adhesiveness/aggregation in the peripheral venous blood: A model in hypercholesterolaemic patients

European Journal of Clinical Investigation

Volumn 33, Issue 11, 2003, Pages 955-961

  Schechner, V ^a,c   Shapira, I ^a,c   Berliner, S ^a,b,c   Comaneshter, D ^a,c   Hershcovici, T ^a,c   Orlin, J ^a,c   Zeltser, D ^a,c   Rozenblat, M ^a,c   Lachmi, K ^a,c   Hirsch, M ^a,c   Beigel, Y ^a,c  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b Inflamet Ltd Company   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Adhesive molecules; Erythrocyte adhesiveness aggregation; LDL apheresis

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN B; C REACTIVE PROTEIN; CHOLESTEROL; FIBRINOGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

APHERESIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; ERYTHROCYTE ADHESIVENESS; ERYTHROCYTE AGGREGATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LINEAR REGRESSION ANALYSIS; LOGISTIC REGRESSION ANALYSIS; MACROMOLECULE; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; PERIPHERAL VEIN; PRIORITY JOURNAL; VENOUS BLOOD;

BLOOD COMPONENT REMOVAL; C-REACTIVE PROTEIN; CELL ADHESION; CHOLESTEROL; ERYTHROCYTE AGGREGATION; ERYTHROCYTES; FIBRINOGEN; HUMANS; HYPERCHOLESTEROLEMIA; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOGLOBULINS; LIPOPROTEINS, LDL; LOGISTIC MODELS; TRIGLYCERIDES;

EID: 10744225581     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2003.01260.x     Document Type: Article

References (21)

1. Soutani M, Suzuki Y, Tateishi N, Maeda N. Quantitative evaluation of flow dynamics of erythrocytes in microvessels: influence of erythrocyte aggregation. Am J Physiol 1995;268:H1959-H1965.
2. Schmid-Schonbein H. Blood rheology and physiology of microcirculation. Ric Clin Lab 1981;11 (Suppl. 1):13-33.
3. Bishop JJ, Nance PR, Popel AS, Intaglietta M, Johson PC. Effect of erythrocyte aggregation on velocity profiles in venules. Am J Physiol 2001;280:H222-H236.
4. 2-permeable tube: effects of erythrocyte aggregation. Am J Physiol Heart Circ Physiol 2001;281:H448-H456.
5. Mchedlishvili G, Gobejishvili L, Mamaladze A, Momtselidze N, Varazashvili M. Microcirculatory stasis induced by hemorheological disorders: further evidence. Microcirc 1999;6:97-106.
6. Cabel M, Meiselman HJ, Popel AS, Johnson PC. Contribution of red blood cell aggregation to venous vascular resistance in skeletal muscle. Am J Physiol 1997;272:H1020-H1032.
7. Fabry TL. Mechanism of erythrocyte aggregation and sedimentation. Blood 1987;70:1572-6.
8. Imaizumi K, Shiga T. Effect of immunoglobulins and IgG-fragments on the human erythrocyte aggregation, studied by rheoscope combined with image analyzer. Biorheology 1983;20:569-77.
9. Vaya A, Martinez M, Carmena R, Aznar J. Red blood cell aggregation and primary hyperlipoproteinemia. Thromb Res 1993;72:119-26.
10. Cicha I, Suzuki Y, Tateishi N, Maeda N. Enhancement of red blood cell aggregation by plasma triglycerides. Clin Hemorheol Microcirc 2001;24:247-55.
11. Weng X, Cloutier G, Beaulieu R, Roederer GO. Influence of acute-phase proteins on erythrocyte aggregation. Am J Physiol 1996;271:H2346-H2352.
12. Klingel R, Fassbender C, Fassbender T, Erdtracht B, Berrouschot J. Rheopheresis: rheologic, functional and structural aspects. Ther Apher 2000;4:348-57.
13. Suckfull M. Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial. Lancet 2002;360:1811-7.
14. Hershcovici T, Elishkewitch K, Rotstein R, Fusman R, Zeltser D, Shapira I et al. The erythrocyte adhesiveness/ aggregation test to reveal real-time information of rheological relevance in patients with familial and primary hypercholesterolemia before and following plasma exchange. Therapeut Apheresis 2002;6:140-4.
15. Rotstein R, Landau T, Twig A, Rubinstein A, Koffler M, Justo D et al. The erythrocyte adhesiveness/aggregation test (EAAT). A new biomarker to reveal the low grade subclinical smoldering inflammation individuals with atherosclerotic risk factors. Atherosclerosis 2002;165:343-51.
16. Fusman G, Mardi T, Justo D, Rozenblat M, Rotstein R, Zeltser D et al. Red blood cell adhesiveness/aggregation, C-reactive protein, fibrinogen and erythrocyte sedimentation rate in healthy adults and in those with atherosclerotic risk factors. Am J Cardiol 2002;90:561-3.
17. Gamzu R, Rotstein R, Fusman R, Zeltser D, Berliner AS, Kupferminc MJ. Increased erythrocyte adhesiveness and aggregation in peripheral venous blood of women with pregnancy-induced hypertension. Obstet Gynecol 2001;98:307-12.
18. Berliner S, Shapira I, Rogowski O, Sadees N, Rotstein R, Fusman R et al. Combined leukocyte and erythrocyte aggregation in the peripheral venous blood during sepsis. A clue to the presence of a commonly shared adhesive protein (s). Int J Clin Lab Res 2000;30:27-31.
19. Sharshun Y, Brill S, Mardi T, Justo D, Rozenblat M, Goldinn Y et al. Inflammation at a glance: erythrocyte adhesiveness/ aggregation to reveal the presence of inflammation in individuals with atherothrombosis. Heart Dis 2003;5:182-3.
20. Rogowski O, Berliner S, Zeltser D, Serov J, Ben Assayag E, Justo D et al. The ERYTRHOSENSE™ as a real time biomarker to reveal the presence of enhanced red blood cell aggregability in atherothrombosis. Heart Dis, in press.
21. Deng LH, Barbenel JC, Lowe GD. Influence of hematocrit on erythrocyte aggregation kinetics for suspensions of red blood cells in autologous plasma. Biorheology 2002;31:193-205.