Automated Analysis of Multiple Sections for the Detection of Occult Cells in Lymph Nodes

Clinical Cancer Research

Volumn 9, Issue 13, 2003, Pages 4826-4834

  Mesker, Wilma E ^a   Doekhie, Fania S ^a   Vrolijk, Hans ^a   Keyzer, Rob ^a   Sloos, Willem C R ^a   Morreau, Hans ^a   O'Kelly, Paddy S ^b   De Bock, Geertruida H ^a   Tollenaar, Rob A E M ^a   Tanke, Hans J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN; MESSENGER RNA;

ARTICLE; AUTOANALYSIS; CANCER STAGING; CELL LABELING; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LABORATORY AUTOMATION; LYMPH NODE METASTASIS; OCCULT CANCER; PRIORITY JOURNAL; PROGNOSIS; RECURRENT CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SENTINEL LYMPH NODE; TECHNIQUE; TISSUE SECTION;

AUTOMATION; BIOCHEMISTRY; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; KERATINS; LYMPH NODES; LYMPHATIC METASTASIS; NEOPLASMS, UNKNOWN PRIMARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 10744225294     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Liefers, G. J., Cleton-Jansen, A. M., van de Velde, C. J., Hermans, J., van Krieken, J. H. J. M., Cornelisse, C. J., and Tollenaar, R. A. E. M. Micrometastases and survival in stage II colorectal cancer. N. Engl. J. Med., 339: 223-228, 1998.
2. Bilchik, A. J., Saha, S., Wiese, D., Stonecypher, J. A., Wood, T. F., Sostring, S., Turner, R. R., Wang, H-J., Morton, D. L., and Hoon, D. S. B. Molecular staging of early colon cancer on the basis of sentinel node analysis: a multicenter Phase II trial. J. Clin. Oncol., 19: 1128-1136, 2001.
3. Wood, T. F., Tsioulias, G. J., Morton, D. L., Rangel, D., Hutchinson, W., Foshag, L. J., Turner, R. R., and Bilchick, A. J. Focussed examination of sentinel lymph nodes upstages early colorectal carcinoma. Am. Surg., 66: 998-1003, 2000.
4. Tsavellas, G., Patel, H., and Allen-Mersh, T. G.: Detection and clinical significance of occult tumour cells in colorectal cancer. Br. J. Surg., 88: 1307-1320, 2001.
5. Cote, R. J., Peterson, H. F., Chaiwun, B., Gelber, R. D., Goldhirsch, A., Castiglione-Gertsch, M., and Neville, A. M. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. Lancet, 345: 896-900, 1999.
6. Giuliano, A. E., Haigh, P. I., Brennan, M. B., Hansen, N. M., Kelley, M. C., Ye, W., Glass, E. C., and Turner, R. R.: Prospective observational study of sentinel lymphadenectomy without further axillary dissection in patients with sentinel node-negative breast cancer. J. Clin. Oncol., 18: 2553-2559, 2001.
7. ADASP recommendations for processing and reporting of lymph node specimens submitted for evaluation of metastatic disease. Virchows Arch., 439: 601-603, 2001.
8. Kelley, W. S., Komorowski, R. A., and Dayer, A. M. Axillary sentinel lymph node examination in breast carcinoma. Arch. Pathol. Lab. Med., 123: 533-535, 1999.
9. Altinyollar, H., Kapucuoglu, N., and Berberoglu, U. Lymphatic mapping and sentinel lymphadenectomy in early stage breast carcinoma. J. Exp. Cancer Res., 19: 141-144, 2000.
10. Liu, L. H., Siziopikou, K. P., Gabram, S., and McClatchey, K. D. Evaluation of axillary sentinel lymph node biopsy by immunohistochemistry and multilevel sectioning in patients with breast carcinoma. Arch. Pathol. Lab. Med., 124: 1670-1673, 2000.
11. Hawes, D., Neville, A. M., and Cote, R. J.: Occult metastases in patients with breast cancer. Ann Surg Oncol., 8 (Suppl. 9). 6OS-63S, 2001.
12. Dowlatshahi, K., Fan, M., Anderson, J. M., and Bloom, K. J. Occult metastases in sentinel nodes of 200 patients with operable breast cancer. Ann. Surg. Oncol., 8: 675-681, 2001.
13. Dowlatshahi, K., Fan, M., Bloom, K. J., Spitz, D. J., Patel, S., and Habib, F. A. Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma, a preliminary study. Cancer (Phila.), 86: 990-996, 1999.
14. Borgen, E., Naume, B., Nesland, J. M., Nowels, K. W., Pavlak, N., Ravkin, I., and Goldbard, S. Use of automated microscopy for the detection of disseminated tumor cells in bone marrow samples. Cytometry, 46: 215-221, 2001.
15. Yasuda, K., Adachi, Y., Shiraishi, N., Yamaguchi, K., Hirabayashi, Y., and Kitano, S. Pattern of lymph node micrometastases and prognosis of patients with colorectal cancer. Ann. Surg. Oncol., 8: 300-304, 2001.
16. Izbicki, J. R., Hosch, S. B., Pichlmeier, U., Rehders, A., Busch, C., Niendorf, A., Passlick, B., Broelsch, C. E., and Pantel, K. Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with completely resected esophageal cancer. N. Engl. J. Med., 17: 1188-1194, 1997.
17. Keene, S. A., and Demeure, M. J. The clinical significance of micrometastases and molecular metastases. Surgery, 129: 1-5, 2001.
18. Turner, R. R., Armando, E. G., Hoon, D. S. B., Glass, E. C., and Krasne, D. L. Pathologic examination of sentinel lymph node for breast carcinoma. World J. Surg., 25: 798-805, 2001.
19. Kell, M. R., Winter, D. C., O'Sullican, G. C., Shanahan, F., and Redmond, H. P. Biological behaviour and clinical implications of micrometastases. Br. J. Surg., 87: 1629-1639, 2000.
20. Tjan-Heijnen, V. C., Buit, P., de Widt-Evert, L. M., Ruers, T. J., and Beex, L. V. Micro-metastases in axillary lymph nodes: an increasing classification and treatment dilemma in breast cancer due to the introduction of the sentinel node procedure. Breast Cancer Res. Treat., 70: 81-88, 2001.
21. Bostick, P. J., Chatterjee, S., Chi, D. D., Huynh, K. T., Giuliano, A. E., Cote, R., and Hoon, D. S. Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients. J. Clin. Oncol., 116: 2632-2640, 1998.
22. Braun, S., Pantel, K., Muller, P., Janni, W., Hepp, F., Kentenich, C. R., Gastroph, S., Wischnik, A., Dimpfl, T., Kindermann, G., Rietmuller, G., and Schlimok, G. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II or III breast cancer. N. Engl. J. Med., 24: 525-533, 2000.
23. Torrenga, H., Rahusen, F. D., Meijer, S., Borgstein, P. J., and van Diest, P. J. Sentinel node investigation in breast cancer: detailed analysis of the yield from step sectioning and immunohistochemistry. J. Clin. Pathol., 54: 550-552, 2001.
24. Klein, C. A., Seidl, S., Petat-Dutter, K., Offner, S., Geigl, J. B., Schmidt-Kittler, O., Wendler, N., Passchlick, B., Huber, R. M., Schlimok, G., Baeuerle, P. A., and Rietmuller, G. Combined transcriptome and genome analysis of single micrometastatic cells. Nat. Biotechnol., 20: 387-392, 2002.
25. Klein, C. A., Blankenstein, T. J. F., Schmidt-Kittler, O., Petriono, M., Polzer, B., Stoecklein, N. H., and Rietmuller, G. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet, 360: 683-689, 2002.
26. Wong, S. L., Chao, C., Edwards, M. J., Simpson, D., and McMasters, K. M. The use of cytokeratin staining in sentinel lymph node biopsy for breast cancer. Am. J. Surg., 182: 330-334, 2001.
27. Merrie, A. E., van Rij, A. M., Philips, L. V., Rossaak, J. I., Yun, K., and Mccall, J. L. Diagnostic use of the sentinel node in colon cancer. Dis. Colon Rectum, 44: 410-417, 2001.
28. Morton, D. L., and Bostick, P. J.: Will the true sentinel node please stand? Ann. Surg. Oncol., 6: 12-14, 1999.
29. Wong, J. H., Steineman, S., Calderia, C., Bowles, J. and Namikil, T. Ex vivo sentinel node mapping in carcinoma of the colon and rectum. Ann. Surg., 233: 515-521, 2001.
30. Chao, C., and McMasters, K. M. Update on the use of sentinel node biopsy in patients with melanoma: who and how. Curr. Opin. Oncol., 14: 217-220, 2002.
31. Statius Muller, M. G., van Leeuwen, P. A. M., de Lange-de Klerk, E. S. M., van Diest, P. J., Pijpers, R., Ferwerda, C. C., Vuylsteke, R. J. C. L. M., and Meijer, S. The sentinel lymph node status is an important factor for predicting clinical outcome in patients with Stage I or II cutaneous melanoma. Cancer (Phila.), 91: 2401-2408, 2001.