Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities

Toxicon

Volumn 43, Issue 1, 2004, Pages 1-9

  Miles, Christopher O ^a,b   Wilkins, Alistair L ^c   Munday, Rex ^a   Dines, Mark H ^a   Hawkes, Allan D ^a   Briggs, Lyn R ^a   Sandvik, Morten ^b   Jensen, Dwayne J ^d   Cooney, Janine M ^d   Holland, Patrick T ^e   Quilliam, Michael A ^f   MacKenzie, A Lincoln ^e   Beuzenberg, Veronica ^e   Towers, Neale R ^a  

^a RUAKURA RESEARCH CENTRE   (New Zealand)

^b NORWEGIAN VETERINARY INSTITUTE   (Norway)

^c UNIVERSITY OF WAIKATO   (New Zealand)

^d THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^e CAWTHRON INSTITUTE   (New Zealand)

^f NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Dinophysis acuta; Enzymatic hydrolysis; LC MS; LD50; NMR; Okadaic acid diol ester; Pectenotoxin 2; Pectenotoxin 2 seco acid; Toxicity

Indexed keywords

MARINE TOXIN; METHANOL; OKADAIC ACID; PECTENOTOXIN 2; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ALGA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIARRHEA; DINOPHYSIS ACUTA; EXTRACTION; HEPATOPANCREAS; HYDROLYSIS; ISOLATION PROCEDURE; LIVER HOMOGENATE; MOUSE; MUSSEL; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SOLVENT EXTRACTION; SUPERNATANT; TECHNIQUE; TOXICITY TESTING; ULTRACENTRIFUGE;

DINOPHYSIS; DINOPHYSIS ACUTA; MYTILUS; MYTILUS EDULIS; PERNA; PERNA CANALICULUS;

EID: 10744224544     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2003.10.003     Document Type: Article

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