IMUP-1 and IMUP-2 Genes are Up-regulated in Human Ovarian Epithelial Tumors

Anticancer Research

Volumn 23, Issue 6 C, 2003, Pages 4709-4713

  Kim, Jin Kyeoung ^a   An, Hee Jung ^a   Kim, Nam Keun ^a   Ahn, Jung Yong ^a   Kim, Kye Seong ^a   Kang, You Jung ^a   Ko, Jung Jae ^a   Oh, Doyeun ^a   Lee, Chan ^a   Kim, Seung Jo ^a   Cha, Kwang Yul ^a  

^a CHA University   (South Korea)

Author keywords

Immortalization; Malignant epithelial tumor; Ovarian neoplasms; Simian virus 40; Tumorigenesis

Indexed keywords

GENE PRODUCT; IMMORTALIZATION UPREGULATED PROTEIN 1; IMMORTALIZATION UPREGULATED PROTEIN 2; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN;

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CARCINOGENESIS; CELL CYCLE; CELL DIVISION; CELL IMMORTALIZATION; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM TUMOR; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMUP 1 GENE; IMUP 2 GENE; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMIAN VIRUS 40;

CARCINOMA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 10744223408     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Ludlow JW: Interaction between SV40 large-tumor antigen and the growth suppressor protein pRB and p53. FASEB J 7: 866-871, 1993.
2. Jha KK, Banga S, Palejwala V and Ozer HL: SV40-mediated immortalization. Exp Cell Res 245: 1-7, 1998.
3. Powell AJ, Darmon AJ, Gonos ES, Lam EW, Peden KW and Jat PS: Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen. Oncogene 18(51): 7343-50, 1999.
4. Shibanuma M, Mashimo J, Kuroki T and Nose K: Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence. J Biol Chem 269: 26767-26774, 1994.
5. Sandhu AK, Kaur GP, Reddy DE, Rane NS and Athwal RS: A gene on 6p 14-21 restores senescence to immortal ovarian tumor cells. Oncogene 12: 247-252, 1996.
6. Garkavstsev I, Kazarov A, Gudkov A and Riabowol K: Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. Nat Genet 14: 415-420, 1996.
7. Banga SS, Kim SH, Hubbard K, Dasgupta T, Jha KK, Patsalis P, Hauptschein R, Gamberi B, Dalla-Favera R, Kraemer P and Ozer HL: SEN6, a locus for SV40-mediated immortalization of human cells, maps to 6q26-27. Oncogene 14: 313-321, 1997.
8. Kim NK, Lee SH, Cha KY and Seo JS: Tissue-specific expression and activation of N-methylpurine-DNA glycosylase in thymic carcinogenesis of transgenic mice expressing the SV40 large T-antigen gene. Mol Cells 8(4): 383-387, 1998.
9. Ma L, Broomfield S, Lavery C, Lin SL, Xiao W and Bacchetti S: Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Oncogene 17: 1321-1326, 1998.
10. Reddy DE, Sandhu AK, DeRiel JK, Athwal RS and Kaur GP: Identification of a gene at 16q24.3 that restores cellular senescence in immortal mammary tumor cells. Oncogene 18: 5100-5107, 1999.
11. Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barret JC, Smith JR and Pereira-Smith OM: Identification of a gene that reverses immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. Mol Cell Biol 19: 1479-1485, 1999.
12. Qing J, Wei D, Maher VM and McCormick JJ: Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines. Oncogene 18: 335-342, 1999.
13. Tsuji T, Miyazaki M, Sakaguchi M, Inoue Y and Namba M: A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem Biophys Res Commun 268: 20-24, 2000.
14. Kim JK, Ryll R, Ishizuka Y and Kato S: Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, up-regulated in SV40-immortalized human fibroblast. Gene 257: 327-334, 2000.
15. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162(1): 156-159, 1987.
16. Tokunaga K, Taniguchi H, Yoda K, Shimizu M and Sakiyama S: Nucleotide sequence of a full-length cDNA for mouse cytoskeletal β-actin mRNA. Nucleic Acids Res 14(6): 2829, 1986.
17. Ercolani L, Florence B, Denaro M and Alexander M: Isolation and complete sequence of a functional human glyceraldehydes-3-phosphate dehydrogenase gene. J Biol Chem 263(30): 15335-15341, 1988.