Effect of dalteparin on healing of chronic foot ulcers in diabetic patients with peripheral arterial occlusive disease: A prospective, randomized, double-blind, placebo-controlled study

Diabetes Care

Volumn 26, Issue 9, 2003, Pages 2575-2580

  Kalani, Majid ^a   Apelqvist, Jan ^b   Blombäck, Margareta ^a   Brismar, Kerstin ^a   Eliasson, Björn ^c   Eriksson, Jan W ^d   Fagrell, Bengt ^a   Hamsten, Anders ^a   Torffvit, Ole ^b   Jörneskog, Gun ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; DALTEPARIN; HEMOGLOBIN A1C; PLACEBO; TROMBYL;

AGED; AMPUTATION; ARTICLE; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC FOOT; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; FOOT ULCER; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; WOUND HEALING IMPAIRMENT;

EID: 10744222973     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.26.9.2575     Document Type: Article

References (30)

1. Apelqvist J, Ragnarson Tennvall G, Persson U, Larsson J: Diabetic foot ulcers in a multidisciplinary setting: an economical analysis of primary healing or healing with amputation. J Intern Med 235:463-471, 1994
2. Apelqvist J: Diabetic Foot Ulcers: The Importance of Clinical Characteristics and Prognostic Factors for the Outcome. Dissertation. Lund, Sweden, University of Lund, 1991
3. Boulton AJM, Connor H, Cavanagh PR: The Foot in Diabetes. 3rd ed. Chichester, U.K., Wiley, 2000
4. Zimny S, Dessel F, Ehren M, Pfohl M, Schatz H: Early detection of microcirculatory impairment in diabetic patients with foot at risk. Diabetes Care 24:1810-1814, 2001
5. Jörneskog G, Brismar K, Fagrell B: Skin capillary circulation is more impaired in toes of diabetic than non-diabetic patients with peripheral vascular disease. Diabet Med 12:36-41, 1995
6. Jörneskog G, Brismar K, Fagrell B: Low molecular weight heparin seems to improve local capillary circulation and healing of chronic foot ulcers in diabetic patients. VASA 2:137-142, 1993
7. Wagner FW: The dysvascular foot: a system for diagnosis and treatment. Foot Ankle 2:64-122, 1981
8. Rith-Najarian SJ, Stolusky T, Gohdes DM: Identifying patients at high risk for lower-extremity amputations in a primary health care setting: a prospective evaluation of simple screening criteria. Diabetes Care 15:1386-1389, 1992
9. Påhlsson H-I, Wahlberg E, Wei SZ, Jörneskog G, Swedenborg J, Olofsson P, Fagrell B: Toe blood pressure measurements with laser Doppler fluxmetry. J Vasc Invest 2:82-86, 1996
10. Apelqvist J, Castenfors J, Larsson J, Stenström A, Agardh CD: Prognostic value of systolic ankle and toe blood pressure levels in outcome of diabetic foot ulcer. Diabetes Care 12:373-378, 1989
11. Apelqvist J, Larsson J, Agardh CD: The importance of peripheral pulses, peripheral oedema and local pain in the outcome of diabetic foot ulcers. Diabetes Med 7:590-594, 1990
12. Kalani M, Brismar K, Fagrell B, Östergren J, Jörneskog G: Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers. Diabetes Care 22:147-151, 1999
13. Assal JP, Muhlhauser I, Pernet A, Gfeller R, Jorgens V, Berger M: Patient education as the basis for diabetes care in clinical practice. Diabetologia 28:602-613, 1985
14. Falkenberg M: Metabolic control and amputations among diabetics in primary health care: a population-based intensified programme governed by patient education. Scand J Prim Health Care 8:25-29, 1990
15. Larsson J, Apelqvist J, Agardh CD, Stenström A: Decreasing incidence of major amputation in diabetic patients: a consequence of a multidisciplinary foot care team approach? Diabet Med 12:770-776, 1995
16. Eneroth M: Amputation for Vascular Disease: Prognostic Factors for Healing, Long-Term Outcome and Costs. Dissertation. Lund, Sweden, Lund University Hospital, 1997
17. Eliasson B, Attvall S, Taskinen MR, Smith U: Smoking cessation improves insulin sensitivity in healthy middle-aged men. Eur J Clin Invest 27:450-456, 1997
18. Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
19. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR: Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 12:405-412, 2000
20. Margolis DJ, Kantor J, Berlin JA: Healing of diabetic neuropathic foot ulcers receiving standard treatment: a meta-analysis. Diabetes Care 22:692-695, 1999
21. Apelqvist J: Wound healing in diabetes: outcome and costs. Clin Pediatr Med Surg 15:21-39, 1998
22. Apelqvist J, Castenfors J, Larsson J, Stenström A, Agardh CD: Wound classification is more important than site of ulceration in the outcome of diabetic foot ulcers. Diabet Med 6:526-530, 1989
23. Ljungberg B: On Heparin and Low Molecular Weight Heparin, Clinical and Experimental Studies. Dissertation. Stockholm, Sweden, Karolinska Institute, 1988
24. Schulman S, Granqvist S, Wiman B, Lockner D: Thrombosis and fibrinolytic parameters during heparin treatment of deep vein thrombosis. Thromb Res 39:607-612, 1985
25. Downing LJ, Strieter RM, Kadell AM, Wilke CA, Greenfield LJ, Wakefield TW: Low-dose low-molecular-weight heparin is anti-inflammantory during venous thrombosis. J Vasc Surg 28:848-854, 1998
26. Edmondson RA, Cohen AT, Das SK, Wagner MB, Kakkar VV: Low molecular weight heparin versus aspirin and dipyridamole after femoropopliteal bypass grafting. Lancet 344:914-918, 1994
27. Fujita M, Sasayama S, Asanoi H, Nakajima H, Sakai O, Ohno A: Improvement of treadmill capacity and collateral circulation as a result of exercise with heparin pretreatment in patients with effort angina. Circulation 77:1022-1029, 1988
28. Fujita M: Heparin and angiogenic therapy. Eur Heart J 21:270-274, 2000
29. Hehenberger K, Kratz G, Hansson A, Brismar K: Fibroblasts derived from human chronic diabetic wounds have a decreased proliferation rate, which is recovered by the addition of heparin. J Dermatol Sci 16:144-151, 1998
30. Kratz G, Back M, Arnander C, Larm O: Immobilised heparin accelerates the healing of human wounds in vivo. Scand J Plast Reconstr Hand Surg 32:381-385, 1998