The ytkD (mutTA) Gene of Bacillus subtilis Encodes a Functional Antimutator 8-Oxo-(dGTP/GTP)ase and Is under Dual Control of Sigma A and Sigma F RNA Polymerases

Journal of Bacteriology

Volumn 186, Issue 4, 2004, Pages 1050-1059

  Ramírez, Martha I ^a   Castellanos Juárez, Francisco X ^a   Yasbin, Ronald E ^b   Pedraza Reyes, Mario ^a  

^a UNIVERSITY OF GUANAJUATO   (Mexico)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXODEOXYGUANOSINE TRIPHOSPHATASE; ALCOHOL; BETA GALACTOSIDASE; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; HYDROGEN PEROXIDE; MESSENGER RNA; MITOMYCIN C; PARAQUAT; RNA POLYMERASE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; BACTERIAL GROWTH; FUSION GENE; GENE EXPRESSION REGULATION; HEAT; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGG GENE; SPOROGENESIS; YTKD GENE;

AMINO ACID SEQUENCE; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BACTERIOCINS; DNA REPAIR ENZYMES; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; GUANOSINE TRIPHOSPHATE; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PEPTIDES; PHOSPHORIC MONOESTER HYDROLASES; PYROPHOSPHATASES; SIGMA FACTOR; SOS RESPONSE (GENETICS); SPORES, BACTERIAL; TRANSCRIPTION, GENETIC;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 10744222909     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.186.4.1050-1059.2004     Document Type: Article

References (62)

1. Abeygunawardana, C., D. J. Weber, A. G. Gittis, D. N. Frick, J. Lin, A. F. Miller, M. J. Bessman, and A. Mildvan. 1995. Solution structure of the MutT enzyme a nucleoside triphosphate pyrophosphohydrolase. Biochemistry 34:14997-15005.
2. Ames, B. N., and D. T. Dubin. 1960. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J. Biol. Chem. 235:769-775.
3. Antelmann, H., S. Engelmann, R. Schmid, and M. Hecker. 1996. General and oxidative stress responses in Bacillus subtilis: cloning, expression, and mutation of the alkyl hydroperoxide reductase operon. J. Bacteriol. 178:6571-6578.
4. F, and KatX is essential for hydrogen peroxide resistance of the germinating spore. J. Bacteriol. 180:2057-2062.
5. Bessman, M. J., D. N. Frick, and S. F. Handley. 1996. The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes. J. Biol. Chem. 271:25059-25062.
6. Bhatnagar, S. K., L. C. Bullions, and M. J. Bessman. 1991. Characterization of the mutT nucleoside triphosphatase of Escherichia coli. J. Biol. Chem. 266:9050-9054.
7. Bol, D. K., and R. E. Yasbin. 1994. Analysis of the dual regulatory mechanisms controlling expression of the vegetative catalase gene of Bacillus subtilis. J. Bacteriol. 176:6744-6748.
8. Boylan, R. J., N. H. Mendelson, D. Brooks, and F. E. Young. 1972. Regulation of the bacterial cell wall: analysis of a mutant of Bacillus subtilis defective in the biosynthesis of teichoic acid. J. Bacteriol. 110:281-290.
9. Bsat, N., L. Chen, and J. D. Helmann. 1996. Mutation of the Bacillus subtilis alkyl hydroperoxide reductase (ahpCF) operon reveals compensatory interactions among hydrogen peroxide stress genes. J. Bacteriol. 178:6579-6586.
10. Bsat, N., and J. D. Helmann. 1999. Interaction of Bacillus subtilis Fur (ferric uptake repressor) with the dhB operator in vitro and in vivo. J. Bacteriol. 181:4299-4307.
11. Bullions, L. C., V. Mejean, J. P. Claverys, and M. J. Bessman. 1994. Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity. J. Biol. Chem. 269:12339-12344.
12. Casillas-Martinez, L., and P. Setlow. 1997. Alkyl hydroperoxide reductase, catalase, MrgA, and superoxide dismutase are not involved in resistance of Bacillus subtilis spores to heat or oxidizing agents. J. Bacteriol. 179:7420-7425.
13. Chen, L., L. Keramati, and J. D. Helmann. 1995. Coordinate regulation of Bacillus subtilis coordinate stress genes by hydrogen peroxide and metal ions. Proc. Natl. Acad. Sci. USA 92:8190-8194.
14. Cheo, D. L., K. W. Bayles, and R. E. Yasbin. 1991. Cloning and characterization of DNA damage-inducible promoter regions from Bacillus subtilis. J. Bacteriol. 173:1696-1703.
15. Clements, L. D., U. N. Streips, and B. S. Miller. 2002. Differential proteomic analysis of Bacillus subtilis nitrate respiration and fermentation in defined medium. Proteomics 2:1724-1734.
16. Cutting, S. M., and P. B. Vander Horn. 1990. Genetic analysis, p. 27-74. In C. R. Harwood and S. M. Cutting (ed.), Molecular biological methods for Bacillus. John Wiley and Sons, Sussex, United Kingdom.
17. Dowds, B. C. A. 1994. The oxidative stress response in Bacillus subtilis. FEMS Microbiol. Lett. 124:255-264.
18. Dunn, C. A., S. O'Handley, D. N. Frick, and M. J. Bessman. 1999. Studies on the ADP-ribose pyrophosphatase subfamily of the Nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. J. Biol. Chem. 274:32318-32324.
19. B-dependent catalase in Bacillus subtilis. J. Bacteriol. 177:5598-5605.
20. Ferrari, E., S. M. H. Haward, and J. A. Hoch. 1985. Effect of sporulation mutations on subtilisin expression, assayed using a subtilisin-β-galactosidase gene fusion, p. 180-184. In J. A. Hoch and P. Setlow (ed.), Molecular biology of microbial differentiation. American Society for Microbiology, Washington, D.C.
21. Frick, D. N., B. D. Townsend, and M. J. Bessman. 1995. A novel GDP-mannose mannosyl hydrolase shares homology with the MutT family of enzymes. J. Biol. Chem. 270:24086-24091.
22. Friedberg, E. C., G. C. Walker, and W. Siede. 1995, DNA repair and mutagenesis. American Society for Microbiology, Washington, D.C.
23. Fujii, Y., H. Shimokawa, M. Sekiguchi, and Y. Nakabeppu. 1999. Functional significance of the conserved residues for the 23-residue among MTH1 and MutT family proteins. J. Biol. Chem. 274:38251-38259.
24. Haldenwang, W. G. 1995. The sigma factors of Bacillus subtilis. Microbiol. Rev. 59:1-30.
25. B regulon. Mol. Microbiol. 19:417-428.
26. Herbig, A. F., and J. D. Helmann. 2001. Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA. Mol. Microbiol. 41:849-859.
27. Inaoka, T., Y. Matsumura, and T. Tsuchido. 1998. Molecular cloning and nucleotide sequence of the superoxide dismutase gene and characterization of its product from Bacillus subtilis. J. Bacteriol. 180:3697-3703.
28. Kakuma, T., J. Nishida., T. Tsuzuki., and M. Sekiguchi. 1995. Mouse MTH1 protein with 8-oxo-7, 8-dihydro-2′-deoxyguanosine5′-triphosphatase activity that prevents transversion mutation. J. Biol. Chem. 270:25942-25948.
29. Kamath, A. V., and C. Yanofsky. 1993. Sequence and characterization of mutT from Proteus vulgaris. Gene 134:99-102.
30. Kamiya, H., and H. Kasai. 1995. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation. J. Biol. Chem. 270:19446-19450.
31. Kroos, L., and S. Cutting. 1994. Intercellular and intercompartmental communication during Bacillus subtilis sporulation, p. 155-180. In P. J. Piggot, C. P. Moran, Jr., and P. Youngman (ed.), Regulation of bacterial differentiation. American Society for Microbiology, Washington, D.C.
32. Kroos, L., B. Zhang, H. Ichikawa, and Y. T. Nicco-Yu. 1999. Control of σ factor activity during Bacillus subtilis sporulation. Mol. Microbiol. 31:1285-1294.
33. Kunst, F., N. Ogasawara, I. Moszer, A. M. Albertini, G. Alloni, V. Azevedo, M. G. Bertero, P. Bessieres, A. Bolotin, S. Borchert, R. Borriss, L. Boursier, A. Brans, M. Braun, S. C. Brignell, S. Bron, S. Brouillet, C. V. Bruschi, B. Caldwell, V. Capuano, N. M. Carter, S. K. Choi, J. J. Codani, I. F. Conerton, A. Danchin, et al. 1997. The complete genome sequence of the Gram positive bacterium Bacillus subtilis. Nature 390:249-256.
34. Londoño-Vallejo, J.-A., C. Frehel, and P. Stragier. 1997. spoIIO, a forespore expressed gene required for engulfment in Bacillus subtilis. Mol. Microbiol. 24:29-39.
35. Love, P. E., and R. E. Yasbin. 1984. Genetic characterization of the inducible SOS-like system of Bacillus subtilis. J. Bacteriol. 160:910-920.
36. Love, P. E., M. S. Lyle, and R. E. Yasbin. 1985. DNA damage inducible (din) loci are transcriptionally activated in competent Bacillus subtilis. Proc. Natl. Acad. Sci. USA 82:6201-6205.
37. Lovett, C. M., Jr., P. E. Love, and R. E. Yasbin. 1989. Competence-specific induction of the Bacillus subtilis RecA protein analog: evidence for dual regulation of a recombination protein. J. Bacteriol. 171:2318-2322.
38. Maki, H., and M. Sekiguchi. 1992. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355:273-275.
39. Mason, J. M., R. H. Hackett, and P. Setlow. 1988. Regulation of expression of genes coding for small, acid-soluble spore proteins of Bacillus subtilis spores: studies using lacZ gene fusions. J. Bacteriol. 170:239-244.
40. McKnight, S. L., and R. Kingsbury. 1982. Transcription control signals of a eukaryotic protein-coding gene. Science 217:316-324.
41. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
42. Mo, J., H. Maki, and M. Sekiguchi. 1992. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. Proc. Natl. Acad. Sci. USA 89:11021-11025.
43. Nicholson, W. L., and P. Setlow. 1990. Sporulation, germination and outgrowth, p. 391-450. In C. R. Harwood and S. M. Cutting (ed.), Molecular biological methods for Bacillus. John Wiley and Sons, Sussex, United Kingdom.
44. G-containing RNA polymerase from sporulating cells of Bacillus subtilis: identification of a group of forespore-specific promoters. J. Bacteriol. 171:2708-2718.
45. O'Handley, S. F., Dunn, C. A., and M. J. Bessman. 2001. Orf135 from Escherichia coli is a Nudix hydrolase specific for CTP, dCTP and 5-methyl-dCTP. J. Biol. Chem. 276:5421-5426.
46. Pedraza-Reyes, M., F. Gutiérrez-Corona, and W. L. Nicholson. 1994. Temporal regulation and forespore-specific expression of the spore photoproduct lyase gene by sigma-G RNA polymerase during Bacillus subtilis sporulation. J. Bacteriol. 176:3983-3991.
47. Raymond-Denise, A., and N. Guillen. 1992. Expression of the Bacillus subtilis dinR and recA genes after DNA damage and during competence. J. Bacteriol. 174:3171-3176.
48. Riley, P. A. 1994. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 65:27-37.
49. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
50. Saran, M., and W. Bors. 1990. Radical reactions in vivo - an overview. Radiat. Environ. Biophys. 29:249-262.
51. Savva, D., and J. Mandelstam. 1984, Cloning of the Bacillus subtilis spoIIA and spoVA loci in phage σ105 DI:1t. J. Gen. Microbiol. 132:2137-2145.
52. Schaeffer, P., J. Millet, and J.-P. Aubert. 1965. Catabolic repression of bacterial sporulation. Proc. Natl. Acad. Sci. USA 54:704-711.
53. Setlow, P. 1989. Forespore-specific genes of Bacillus subtilis: function and regulation of expression, p. 211-221. In I. Smith, R. Slepecky, and P. Setlow (ed.), Regulation of prokaryotic development: structural and functional analysis of bacterial sporulation and germination. American Society for Microbiology, Washington, D.C.
54. Setlow, P. 1994. Mechanisms that contribute to the long-term survival of spores of Bacillus species. J. Appl. Bacteriol. 176(Suppl.):49S-60S.
55. Simic, M. G., K. A. Taylor., J. F. Ward, and C. Von Sonntag (ed.). 1988. Oxygen radicals in biology and medicine. Basic life sciences, vol. 49. Plenum Publishing Corp., New York, N.Y.
56. Storz, G., and J. A. Imlay. 1999. Oxidative stress. Curr. Opin. Microbiol. 2:188-194.
57. Storz, G., and M. Zheng. 2000. Oxidative stress, p. 47-59. In G. Storz and R. Hengge-Aronis (ed.), Bacterial stress responses. American Society for Microbiology, Washington, D.C.
58. Sukumi, K., M. Furuichi, T. Tsusuki, T. Kakuma, S.-I. Kabawata, H. Maki, and M. Sekiguchi. 1993. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-Oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268:23524-23530.
59. Taddei, F., H. Hayakawa, M. F. Bouton, A. M. Cirinesi, L. Matic, M. Sekiguchi, and M. Radman. 1997. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278:128-130.
60. Urtiz-Estrada, N., J. M. Salas-Pacheco, R. E. Yasbin, and M. Pedraza-Reyes. 2003. Forespore-specific expression of Bacillus subtilis yqfS, which encodes type IV apurinic/apyrimidinic endonuclease, a component of the base excision repair pathway. J. Bacteriol. 185:340-348.
61. B-dependent general stress regulon confers multiple stress resistance in Bacillus subtilis. J. Bacteriol. 181:3942-3948.
62. Winterling, K. W., D. Chafin, J. J. Hayes, J. Sun., A. S. Levine, R. E. Yasbin, and R. Woodgate. 1998. The Bacillus subtilis DinR binding site: redefinition of the consensus sequence. J. Bacteriol. 180:2201-2211.