Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 98, Issue 1, 2004, Pages 28-42

  de Oliveira Pardal, Pedro Pereira ^a   Souza, Suzana Medeiro ^a   da Costa Monteiro, Maria Rita de Cássia ^a   Fan, Hui Wen ^b   Cardoso, Jaão Luiz Costa ^b   França, Francisco Oscar Siqueira ^b   Tomy, Sandra Corrallo ^b   Sano Martins, Ida S ^b   de Sousa e Silva, Maria Cristina Cirillo ^b   Colombini, Mônica ^b   Kodera, Nancy F ^b   Moura da Silva, Ana Maria ^b   Cardoso, Diva Ferreira ^b   Velarde, David Toledo ^c   Kamiguti, Aura S ^d   Theakston, Robert David G ^e   Warrell, David A ^e,f  

^a Hosp Univ Joao de Barros Barreto   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

^c FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Amazonia; Antivenom; Bothrops atrox; Brazil; Clinical trial; Lachesis muta; Snakebite

Indexed keywords

BATROXOBIN; HYDROCORTISONE; PROMETHAZINE; SNAKE VENOM ANTISERUM;

ABDOMINAL PAIN; ADOLESCENT; ADULT; AGED; ANAPHYLAXIS; ARTICLE; BLOOD CLOTTING DISORDER; BRAZIL; CHILD; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DRUG BLOOD LEVEL; DRUG EFFICACY; DYSPNEA; ENVENOMATION; ENZYME IMMUNOASSAY; FEMALE; GEOGRAPHY; HEMOSTASIS; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NAUSEA AND VOMITING; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SKIN NECROSIS; SNAKE; SNAKEBITE; SPECIES DIFFERENCE; SUPERINFECTION; URTICARIA;

BOTHROPS; BOTHROPS ATROX; LACHESIS; LACHESIS MUTA; SERPENTES;

EID: 10744222145     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(03)00005-1     Document Type: Article

References (50)

1. Amaral, C.F.S., Rezende, N.A., Silva, A.O., Ribeiro, M.M.F., Magalhães, R.A., Reis, R.J., Carneiro, J.G., Castro, J.R.S., 1986. Insuficiência renal aguda secundária a acidente ofídico botrópico e crotálico. Análise de 63 casos. Rev. Inst. Med. Trop. São Paulo 28, 220-227.
2. Assakura, M.T., Furtado, M.F., Mandelbaum, F.R., 1992. Biochemical and biological differentiation of the venoms of the lancehead vipers (Bothrops atrox, Bothrops asper, Bothrops marajoensis and Bothrops moojeni). Comp. Biochem. Physiol. 102B, 727-732.
3. Bard, R., De Lima, J.C.R., De Sá-Neto, R.P., De Oliveira, S.G., Dos Santos, M.C., 1994. Ineficácia do antiveneno botrópico na neutralização da atividade coagulante do veneno de Lachesis muta muta. Relato de caso e comprovação experimental. Rev. Inst. Med. Tropical São Paulo 36, 77-81.
4. Borges, C.C., Sadahiro, M., Dos Santos, M.C., 1999. Aspectos epidemiológicos e clínicos dos acidentes ofídicos ocorridos nos municípios do Estado do Amazonas. Rev. Soc. Bras. Med. Trop. 33, 637-646.
5. Brasil, Ministério da Saúde, 1996. Normas de Produção e Controle de Qualidade de Soros Antiofídicos. Diário Oficial da União, 23.491-23.512.
6. Brasil, Ministério da Saúde. Fundação Nacional de Saúde, 1998. Manual de diagnóstico e tratamento de acidentes por animais peçonhentos, Brasília.
7. Brazil, V., 1901. Contribuição ao estudo do veneno ophidico. III. Tratamento das mordeduras das cobras. Rev. Méd. São Paulo 4, 375-380.
8. Campbell, J.A., Lamar, W.W., Greene, H.(Eds), 2003. The Venomous Reptiles of The Western Hemisphere. Cornell University Press, New York, in press.
9. Cardoso, J.L.C., Fan, H.W., França, F.O.S., Jorge, M.T, Leite, R.R. Nishioka, S.A., Avila, A., Sano-Martins, I.S., Tomy, S.C., Santoro, M.L., Chudzinski, A.M., Castro, S.C.B., Kamiguti, A.S., Kelen, E.M.A., Hirata, M.H., Mirandola, R.M.S., Theakston, R.D.G,, Warrell, D.A., 1993. Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in São Paulo. Brazil. Q. J. Med. 86, 315-325.
10. Chaves, F., Barboza, M., Gutiérrez, J.M., 1995. Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice. Toxicon 33, 31-39.
11. Chavez-Olortegui, C., Lopes, C.S., Cordeiro, F.D., Granier, C., Diniz, C.R., 1993. An enzyme linked immunosorbent assay (ELISA) that discriminates between Bothrops atrox and Lachesis muta muta venoms. Toxicon 31, 417-425.
12. Colombini, M., Fernandes, I., Cardoso, D.F., Moura-da-Silva, A.M., 2001. Lachesis muta muta venom: Immunological differences compared with Bothrops atrox venom and importance of specific antivenom therapy. Toxicon 39, 711-719.
13. Cunha, O.R., Nascimento, F.P., 1993. Ofídios da Amazônia. As cobras da região teste do Pará. Bol. Mus. Par. Emílio Goeldi. Sér. Zoologia 9, 126-128.
14. Cupo, P., Azevedo-Marques, M.M., Menezes, J.B., Hering, S.E., 1991. Reações de hipersensibilidade imediatas após uso intravenoso de soros antivenenos: valor prognóstico dos testes de sensibilidade intradérmicos. Rev. Inst. Med. Trop. São Paulo 33, 115-122.
15. Dias da Silva, W., Guidolin, R., Raw, I., Higashi, H.G., Caricati, C.P., Morais, J.F., Lima, M.L.S.R., Yamaguchi, I.K., Nishikawa, A.K., Stephano, M.A., Marcelino, J.R., Pinto, J.R., Santos, M.J., 1989. Cross-reactivity of horse monovalent antivenoms to venoms of ten Bothrops species. Mem. Inst. Butantan 51, 153-168.
16. Fan, H.W., Marcopito, L.F., Cardoso, J.L.C., França, F.O.S., Malaque, C.M.S., Ferrari, R.A., Theakston, R.D.G., Warrell, D.A., 1999. Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for Bothrops snake bites. BMJ 318, 1451-1453.
17. Farsky, S.H.P., Walber, J., Costa-Cruz, M., Cury, Y., Teixeira, C.F., 1997. Leukocyte response induced by Bothrops jararaca crude venom: in vivo and in vitro studies. Toxicon 35, 185-193.
18. Furtado, M.F., Maruyama, M., Kamiguti, A.S., Antonio, L.C., 1991. Comparative study of nine Bothrops snake venoms from adult female snakes and their offspring. Toxicon 29, 219-226.
19. Ho, M., Warrell, M.J., Warrell, D.A., Bidwell, D., Voller, A., 1986. A critical reappraisal of the use of enzyme-linked immunosorbent assays in the study of snake bite. Toxicon 24, 211-221.
20. Jorge, M.T, Cardoso, J.L.C., Castro, S.C.B., Ribeiro, L.A., França, F.O.S., Sbrogio de Almeida, M.E., Kamiguti, A.S., Sano-Martins, I.S., Santoro, M.L., Moncau, J.E.C., Warrell, D.A., Theakston, R.D.G., 1995. A randomized blinded comparison of two doses of antivenom in the treatment of Bothrops envenoming in São Paulo. Brazil. Trans. R. Soc. Trop. Med. Hyg. 89, 111-114.
21. Jorge, M.T., Sano-Martins, I.S., Tomy, S.C., Castro, S.C.B., Ferrari, R.A., Ribeiro, L.A., Warrell, D.A., 1997. Snakebite by the bushmaster (Lachesis muta) in Brazil: case report and review of the literature. Toxicon 35, 545-554.
22. Kamiguti, A.S., Matsunaga, S., Spir, M., Sano-Martins, I.S., Nahas, L., 1986. Alterations of the blood coagulation system after accidental human inoculation by Bothrops jararaca venom. Braz. J. Med. Biol. Res. 19, 199-204.
23. Kouyoumdjian, J.A., Polizelli, C., Lobo, S.M., Guimarães, S.M., 1991. Fatal extradural haematoma after snake bite (Bothrops moojeni). Trans. R. Soc. Trop. Med. Hyg. 85, 552.
24. Lustgarten, J.A., Wenk, R.E., 1972. Simple rapid kinetic method for serum creatinine injurement. Clin. Biochem. 18, 1419-1422.
25. Malasit, P., Warrell, D.A., Chanthavanich, A.P., Viravan, C., Mongkolsapaya, J., Singhthong, B., Supich, C., 1986. Prediction, prevention and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites. Br. Med. J. 292, 17-20.
26. Maruyama, M., Kamiguti, A.S., Cardoso, J.L.C., Sano-Martins, I.S., Chudzinski, A.M., Santoro, M.L., Morena, P., Tomy, S.C., Antonio, L.C., Mihara, H., Kelen, E.M.A., 1990. Studies on blood coagulation and fibrinolysis in patients bitten by Bothrops jararaca (jararaca). Thromb. Haemost. 63, 449-453.
27. Muniz, E.G., Maria, W.S., Estevão-Costa, M.I., Burnheim, P., Chávez-Olórtegui, C., 2000. Neutralizing potency of horse antibothropic Brazilian antivenom against Bothrops snake venoms from the Amazon rain forest. Toxicon 38, 1859-1863.
28. Otero, R., Cardoso, J.L.C., Higashi, H.G., Nunez, V., Diaz, A., Toro, M.F., Garcia, M.E., Sierra, A., Garcia, L.F., Moreno, A.M., Medina, M.C., Castañeda, N., Silva-Diaz, J.F., Murcia, M., Cardenas, S.Y., Dias da Silva, W.D., 1998. A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for Bothrops sake bites in Uraba. Colômbia. Am. J. Trop. Med. Hyg. 58, 183-189.
29. Otero, R., Gutiérrez, J.M., Núnez, V., Robles, A., Estrada, R., Segura, E., Toro, M.F., García, M.E., Díaz, A., Ramirez, E.C., Gómez, G., Castañeda, J., Moreno, M.E., 1996. A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. Trans. R. Soc. Trop. Med. Hyg. 90, 696-700.
30. Otero, R., Tobón, G.S., Gómez, L.F., Osório, R.G., Valderrama, R., 1993. Bites from the bushmaster (Lachesis muta) in Antioquia and Chocó, Colombia, report of five accidents. Toxicon 31, 158-159.
31. Otero, R., Vitelbina, N., Osorio, R.G., Gutiérrez, J.M., Giraldo, C.A., Posada, L.E., 1995. Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia). Toxicon 33, 809-815.
32. Pardal, P.P.O., Barral Neto, M., Schriefer, A., Rezende, M.B., Magalhães, F.E., Raiol, C.S., 1993. Acidentes ofídicos por Bothrops nos municípios de Portel e Inhangapi - PA. Pará Médico 2, 7-14.
33. Pardal, P.P.O., Mazzeo, T., Pinheiro, A.C.L., 1997a. Snakebite in pregnancy: a preliminary study. J. Ven. Anim. Toxins 3, 280-286.
34. Pardal, P.R.O., Rezende, M.B., Dourado, H.V., 1997b. Acidentes ofídicos. In Doenças Infecciosas e Parasitárias. Enfoque amazônico, Queirz-de-Leão R. N. (editor). Belém: editora CEJUP, pp. 805-812.
35. Phillips, R.E., Theakston, R.D.G., Warrell, D.A., Galagedera, Y., Abeysekera, D.T.D.J., Dissanayake, P., Hutton, R.A., Aloysius, D.J., 1988. Paralysis, rhabdomyolysis and haemolysis caused by bites of Russell's viper (Vipera russelli pulchella) in Sri Lanka: failure of Indian (Haffkine) antivenom. Q. J. M. 68, 691-716.
36. Pierini, S.V., Warrell, D.A., De Paulo, A., Theakston, R.D.G., 1996. High incidence of bites and stings by snakes and other animals among rubber tappers and Amazonian indians of the Juruá valley, Acre state. Brazil. Toxicon 34, 225-236.
37. Ratnoff, O.D., Menzie, C., 1951. A new method for the determinantion of fibrinogen in small samples of plasma. J. Lab. Clin. Med. 37, 316-320.
38. Raw, I., Guidolin, R., Higashi, H.G., Kelen, E.M.A., 1991. Antivenins in Brazil: Preparation, in Handbook of Natural Toxins, Tu A. (Ed.), Marcel Dekker, New York, pp. 557-811.
39. Rodrigues, V.M., Soares, A.M., Mancin, A., Fontes, R.M., Homsi-Brandeburgo, M.I., Giglio, J.R., 1998. Geographic variations in the composition of myotoxins from Bothrops neuwiedi snake venoms: biochemical characterization and biological activity. Comp. Biochem. Physiol. 121A, 209-214.
40. Sano-Martins, I.S., Fan, H.W., Castro, S.C.B., Tomy, S.C., França, F.O.S., Jorge, M.T., Kamiguti, A.S., Warrell, D.A., Theakston, R.D.G., 1994. Reliability of the simple 20 minute whole blood clotting test (WBCT20) as an indicator of low plasma fibrinogen concentration in patients envenomed by Bothrops snakes. Toxicon 32, 1045-1050.
41. Silva, J.J., 1989. Las serpientes del genero Bothrops em la amazonia colombiana. Aspectos biomédicos (epidemiologia, clínica y biologia del ofidismo). Act. Med. Colombiana 14, 148-165.
42. Theakston, R.D.G., Fan, H.W., Warrell, D.A., Dias-da-Silva, W.D., Ward, S.A., Higashi, H.G., 1992. Use of enzyme immunoassays to compare the effect and assess the dosage regimens of three Brazilian Bothrops antivenoms. Am. J. Trop. Med. Hyg. 47, 593-604.
43. Theakston, R.D.G., Lloyd-Jones, M.J., Reid, H.A., 1977. Micro-ELISA for detecting and assaying snake venom and venom-antibody. Lancet, ii, 639-641.
44. Theakston, R.D.G., Warrell, D.A., Griffiths, E., 2003. Report of a WHO Workshop on the Standardization and Control of antivenoms. Toxicon 41, 541-557.
45. Torres, R.J., Torres, A.M.A., Arroyo-Parejo, M.A., 1995. Coagulation disorders in bushmaster envenomation (Letter). Lancet 346, 449-450.
46. Trebien, H.A., Calixto, J.B., 1989. Pharmacological evaluation of rat paw edema induced by Bothrops jaroraca venom. Agents Actions 26, 292-300.
47. Warrell, D.A., 2003. Epidemiology, clinical features and management of snakebites in Central and South America, in Campbell J, Lamar W.W., Greene H. (Eds.), Venomous Reptiles of The Western Hemisphere, Cornell University Press, New York, in press.
48. Warrell, D.A., Davidson, N.Mc.D., Greenwood, B.M., Ormerod, L.D., Pope, H.M., Watkins, B.J., Prentice, C.R.M., 1977. Poisoning by bites of the saw-scaled or carpet viper (Echis carinatus) in Nigeria. Q. J. Med. 46, 33-42.
49. Warrell, D.A., Looareesuwan, S., Theakston, R.D.G., Phillips, R.E., Chanthavanich, P., Viravan, C., Supanaranond, W., Karbwang, J., Ho, M., Hutton, R.A., Vejcho, S., 1986. Randomized comparative trial of three monospecific antivenoms for bites by the Malayan pit viper (Calloselasma rhodostoma) in southern Thailand: clinical and laboratory correlations. Am. J. Trop. Med. Hyg. 35, 1235-1247.
50. WHO, 1981. Progress and Characterization of Venoms and Stardardization of Antivenoms. WHO Offset Publication no. 58.