An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin

Forensic Science International

Volumn 133, Issue 1-2, 2003, Pages 107-112

  Kinoshita, Hiroshi ^a   Taniguchi, Tadaaki ^a   Nishiguchi, Minori ^a   Ouchi, Harumi ^a   Minami, Takako ^a   Utsumi, Takao ^a   Motomura, Hiroyuki ^b   Tsuda, Toyohiko ^a   Ohta, Takehiko ^a   Aoki, Shigeru ^a   Komeda, Motoo ^a   Kamamoto, Tetsuji ^a   Kubota, Akira ^a   Fuke, Chiaki ^c   Arao, Tomonori ^c   Miyazaki, Tetsuji ^c   Hishida, Shigeru ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b Hyogo Prefectural Police Headquarters   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Digoxin; Drug interaction; Metoprolol; Poisoning; Verapamil

Indexed keywords

DIGOXIN; METOPROLOL; VERAPAMIL;

ADULT; AUTOPSY; BRADYCARDIA; BUILDING; CADAVER; CASE REPORT; CAUSE OF DEATH; CLINICAL EXAMINATION; CONFERENCE PAPER; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG FATALITY; DRUG INTOXICATION; DRUG OVERDOSE; HEART FAILURE; HUMAN; HUMAN TISSUE; HYPOTENSION; MALE; PRESCRIPTION; PRIORITY JOURNAL; SUICIDE;

EID: 10744222020     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(03)00056-2     Document Type: Conference Paper

References (35)

1. R.C. Baselt. Verapamil, in: Disposition of Toxic Drugs and Chemicals in Man, fifth ed., Chemical Toxicology Institute, Foster City, CA, 2000, pp. 876-878.
2. Kroemer H.K., Gautier J.-C., Beaune P., Henderson C., Wolf C.R., Eichelbaum M. Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn-Schmiedeberg's Arch. Pharmacol. 348:1993;332-337.
3. American Medical Association, Calcium channel blocking drugs, in: Drug Evaluations Annual 1995, American Medical Association, 1995, pp. 581-599.
4. Gelbke H.P., Schlicht H.J., Schmidt G. Fatal poisoning with verapamil. Arch. Toxicol. 37:1977;89-94.
5. Orr G.M., Bodansky H.J., Dymond D.S., Taylor M. Fatal verapamil overdose. Lancet. 8309:1982;1218-1219.
6. Crouch D.J., Crompton C., Rollins D.E., Peat M.A., Francom P. Toxicological findings in a fatal overdose of verapamil. J. Forensic Sci. 31:1986;1505-1508.
7. Chan L.F.T., Chhuy L.H., Crowley R.J. Verapamil tissue concentrations in fatal cases. J. Anal. Toxicol. 11:1987;171-174.
8. Koepke J.F., McBay A.J. Fatal verapamil poisoning. J. Forensic Sci. 32:1987;1431-1434.
9. Hofer C.A., Smith J.K., Tenholder M.F. Verapamil intoxication: a literature review of overdoses and discussion of therapeutic options. Am. J. Med. 95:1993;431-438.
10. Janowska E.J., Chudzikiewicz E.M. A report of suicide involving verapamil. Vet. Hum. Toxicol. 38:1996;210-211.
11. R.C. Baselt, Metoprolol, in: Disposition of Toxic Drugs and Chemicals in Man, fifth ed., Chemical Toxicology Institute, Foster City, CA, 2000, pp. 573-575.
12. Johnson J.A., Burlew B.S. Metoprolol metabolism via cytochrome P450 2D6 in ethnic populations. Drug Metab. Dispos. 24:1996;350-355.
13. American Medical Association, Beta-adrenergic blocking drugs, in: Drug Evaluations Annual 1995, American Medical Association, 1995, pp. 569-579.
14. Shore E.T., Cepin D., Davidson M.J. Metoprolol overdose. Ann. Emerg. Med. 10:1981;524-527.
15. Stajic M., Granger R.H., Beyer J.C. Fatal metoprolol overdose. J. Anal. Toxicol. 8:1984;228-230.
16. Rohrig T.P., Rundle D.A., Leifer W.N. Fatality resulting from metoprolol overdose. J. Anal. Toxicol. 11:1987;231-232.
17. Mozayani A., Singer P., Jones G. Distribution of metoprolol enantiomers in a fatal overdose. J. Anal. Toxicol. 19:1995;519-521.
18. American Medical Association, Drugs used for heart failure, in: Drug Evaluations Annual 1995, American Medical Association, 1995, pp. 685-702.
19. R.A. Kelly, T.W. Smith, Pharmacological treatments of heart failure, in: J.G. Hardman, L.E. Limberd, P.B. Molinoff, R.W. Ruddon, A. Goodman Gilman (Eds.), Goodman & Gilman's: The Pharmacological Basis of Therapeutics, ninth ed., McGraw-Hill, New York, 1995, pp. 809-838.
20. Kunsman G.W., Kunsman C.M., Presses C.L., Garavaglia J.C., Farley N.J. A mixed-drug intoxication involving venlafaxine and verapamil. J. Forensic Sci. 45:2000;926-928.
21. Arao T., Fuke C., Takaesu H., Nakamoto M., Morinaga Y., Miyazaki T. Simultaneous determination of cardenolides by sonic spray ionization liquid chromatography-ion-trap mass spectrometry - a fatal case of oleander poisoning. J. Anal. Toxicol. 26:2002;222-227.
22. Koike Y., Shimamura K., Shudo I., Saito H. Pharmacokinetics of verapamil in man. Res. Commun. Chem. Path. Pharm. 24:1979;37-46.
23. Buckley C.D., Aronson J.K. Prolonged half-life of verapamil in a case of overdose: implications for therapy. Br. J. Clin. Pharmacol. 39:1995;680-683.
24. Kivisto K.T., Neuvonen P.J., Tarssanen L. Pharmacokinetics of verapamil in overdose. Hum. Exp. Toxicol. 16:1997;35-37.
25. R.C. Baselt, Digoxin, in: Disposition of Toxic Drugs and Chemicals in Man, fifth ed., Chemical Toxicology Institute, Foster City, CA, 2000, pp. 271-276.
26. Wayne V.S., Harper R.W., Laufer E., Federman J., Anderson S.T., Pitt A. Adverse interaction between beta-adrenergic blocking drugs and verapamil - report of three cases. Aust. N. Z. J. Med. 12:1982;285-289.
27. Wayne V.S. Interaction of calcium channel and beta-adrenergic blocking agents. J. Am Coll. Cardiol. 2:1983;594-595.
28. Henry M., Kay M.M., Viccellio P. Cardiogenic shock associated with calcium channel and beta blockers: reversal with intravenous calcium chloride. Am. J. Emerg. Med. 3:1985;334-336.
29. McLean A.J., Knight R., Harrison P.M., Harper R.W. Clearance-based oral drug interaction between verapamil and metoprolol and comparison with atenolol. Am. J. Cardiol. 55:1985;1628-1629.
30. Keech A.C., Harper R.W., Harrison P.M., Pitt A., McLean A.J. Pharmacokinetic interaction between oral metoprolol and verapamil for angina pectoris. Am. J. Cardiol. 58:1986;551-552.
31. Ma B., Prueksaritanont T., Lin J.H. Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab. Dispos. 28:2000;125-130.
32. Pedersen K.E., Dorph-Pedersen A., Hvidt S., Klitgaard N.A., Nielsen-Kudsk F. Digoxin-verapamil interaction. Clin. Pharmacol. Ther. 30:1981;311-316.
33. Belz G.G., Doering W., Munkes R., Matthews J. Interaction between digoxin and calcium antagonists and antiarrhythmic drugs. Clin. Pharmacol. Ther. 33:1983;410-417.
34. Rodin S.M., Johnson B.F., Wilson J., Ritchie P., Johnson J. Comparative effects of verapamil and isradipine on steady-state digoxin kinetics. Clin. Pharmacol. Ther. 43:1988;668-672.
35. Takara K., Kakumoto M., Tanigawara Y., Funakoshi J., Sakaeda T., Okumura K. Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 70:2002;1491-1500.