Idiopathic Thrombocytopenic Purpura: Better Therapeutic Responses of Patients with B- or T-Cell Clonality than Patients without Clonality

International Journal of Hematology

Volumn 78, Issue 5, 2003, Pages 461-466

  Kim, J ^a   Park, Chan Jeoung ^a   Chi, H S ^a   Kim, M J ^a   Seo, J J ^a   Moon, H N ^a   Ghim, T T ^a   Kim, S W ^a   Lee, J H ^a   Lee, G H ^a   Lee, J S ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Idiopathic thrombocytopenic purpura; Immunoglobulin heavy chain gene rearrangement; T cell receptor chain gene rearrangement; Therapeutic response

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOSUPPRESSIVE AGENT; PRIMER DNA; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BONE MARROW BIOPSY; CHILD; CLONAL VARIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DETERMINATION; GENE FREQUENCY; GENE REARRANGEMENT; HELPER CELL; HUMAN; HUMAN TISSUE; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN STRUCTURE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOREGULATION; LYMPHOCYTE CLONE; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 10744220198     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02983822     Document Type: Article

References (22)

1. George JN, Raskob GE. Idiopathic thrombocytopenic purpura: a concise summary of the pathophysiology and diagnosis in children and adults. Semin Hematol. 1989;35:5-8.
2. Semple JW. Immunobiology of T helper cells and antigen-presenting cells in autoimmune thrombocytopenic purpura. Acta Paediatr Suppl. 1998;424:41-45.
3. Okubo M, Kurokawa M, Ohto H, et al. Clonotype analysis of peripheral blood T cells and autoantigen-reactive T cells from patients with mixed connective tissue disease. J Immunol. 1994;153:3784-3790.
4. + T cells in rheumatoid arthritis. J Clin Invest. 1994;94:2068-2076.
5. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. J Clin Invest. 1998;102:1393-1402.
6. Shimomura T, Fujimura K, Takafuta T, et al. Oligoclonal accumulation of T cells in peripheral blood from patients with idiopathic thrombocytopenic purpura. Br J Haematol. 1996;95:732-737.
7. Ware RE, Howard TA. Elevated numbers of gamma-delta (γδ+) T lymphocytes in children with immune thrombocytopenic purpura. J Clin Immunol. 1994;14:237-247.
8. van der Harst D, de Jong D, Limpens J, et al. Clonal B-cell populations in patients with idiopathic thrombocytopenic purpura. Blood. 1990;76:2321-2326.
9. Stockelberg D, Hou M, Jacobsson S, et al. Evidence for a light chain restriction of glycoprotein Ib/IX and IIb/IIIa reactive antibodies in chronic idiopathic thrombocytopenic purpura. Br J Haematol. 1995;90:175-179.
10. McMillan R, Lopez-Dee J, Bowditch R. Clonal restriction of platelet-associated anti-GPIIb/IIIa autoantibodies in patients with chronic ITP. Thromb Haemost. 2001;85:821-823.
11. George JN, Woolf SH, Raskob GE. Idiopathic thrombocytopenic purpura: a practical guideline developed by explicit methods for the American Society of Hematology. Blood. 1996;88:3-40.
12. Torlakovic E, Cherwitz DL, Jessuran J. B-cell gene rearrangement in benign and malignant lymphoid proliferations of mucosa-associated lymphoid tissue and lymph nodes. Hum Pathol. 1997;28:166-173.
13. Trainor KJ, Brisco MJ, Wan JH. Gene rearrangement in B-and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood. 1991;78:192-196.
14. McMillan R, Tani P, Millard F, et al. Platelet-associated and plasma-antiglycoprotein autoantibodies in chronic ITP. Blood. 1987;70:1040-1045.
15. Logtenberg T, Young FM, Van Es JH, et al. Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene. J Exp Med. 1989;170:1347-1355.
16. van Dijk-Hard I, Feld S, Holmberg D, Lundkvist I. Increased utilization of the VH6 gene family in patients with autoimmune idiopathic thrombocytopenic purpura. J Autoimmun. 1999;12:57-63.
17. Filion MC, Proulx C, Bradley AJ, et al. Presence in peripheral blood of healthy individuals of autoreactive T cells to a membrane antigen present on blood marrow-derived cells. Blood. 1996;88:2144-2154.
18. Mamula MJ. The inability to process a self-peptide allows autoreactive T cells to escape tolerance. J Exp Med. 1993;177:567-571.
19. Kuwana M, Kaburaki J, Kitasato H, et al. Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura. Blood. 2001;98:130-139.
20. Jasani B. Immunological definable light chain restriction in autoimmune disease. J Pathol. 1988;154:1-5.
21. Mazzucconi MG, Piola P, Arista MC, et al. Modification of lymphocyte subsets in autoimmune thrombocytopenic purpura patients submitted to splenectomy. Haematologica. 2000;85:776-777.
22. Kuwana M, Kaburaki J, Pandey JP, et al. HLA class II alleles in Japanese patients with immune thrombocytopenic purpura associations with antiplatelet glycoprotein autoantibodies and responses to splenectomy. Tissue Antigens. 2000;56:337-343.