Type I error and power in trials with one interim futility analysis

Pharmaceutical Statistics

Volumn 3, Issue 1, 2004, Pages 51-59

  Chang, William H ^a   Chuang Stein, Christy ^b  

^a ASTRAZENECA   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Conditional power; Futility analysis; Type I error

Indexed keywords

ANALYTICAL ERROR; ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; HYPOTHESIS; METHODOLOGY; NORMAL DISTRIBUTION; RISK ASSESSMENT; SAMPLE SIZE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 10644246044     PISSN: 15391604     EISSN: None     Source Type: Journal    
DOI: 10.1002/pst.93     Document Type: Article

References (4)

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2. 0 and incorporating costs", Biometrika, 69.1, 75-80, 1982.
3. Gould AL. Abandoning lost causes (early termination of unproductive clinical trials). American Statistical Association Proceedings of the Biopharmaceutical Section, 31-4, 1983.
4. Pepe MS, Anderson GL. Two-stage experimental designs: early stopping with a negative result. Applied Statistics 1992; 41 181-190.