Separation and purification of stigmasterol and ß-sitosterol from phytosterol mixtures by solvent crystallization method

Separation and Purification Technology

Volumn 41, Issue 2, 2005, Pages 173-178

  Xu, Wen Lin ^a   Huang, Yi Bo ^a   Qian, Jun Hong ^a   Sha, Ou ^a   Wang, Ya Qiong ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

Sitosterol; Crystallization; Purification; Separation; Stigmasterol

Indexed keywords

ACETIC ACID; AROMATIC HYDROCARBONS; CRYSTALLIZATION; MELTING; PHASE DIAGRAMS; PURIFICATION; SEPARATION; SOLUBILITY; SOLVENTS; TERNARY SYSTEMS;

Β-SITOSTEROL; DEBROMINATION; PHYTOSTEROLS; STIGMASTEROL;

ALCOHOLS;

EID: 10644240984     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2004.02.005     Document Type: Article

References (16)

1. H.J. Thomas, S.C. Li, C.G. John, Phytosterol content in American ginseng seed oil, J. Agric. Food Chem. 50 (2002) 744.
2. D. Swern, Bailey's Industrial Oil and Fat Products, vol. 1, fourth ed., Wiley, New York, 1979 (Chapter 1).
3. R.T. Holman, W.O. Lundberg, T. Malkin, Progress in the Chemistry of Fats and Other Lipids, vol. 1, Pergamon Press, London, 1952 (Chapter 2).
4. W.H. Ling, P.J.H. Jones, Minireview dietary phytosterols: a review of metabolism, benefits and side effects, Life Sci. 573 (1995) 195.
5. M.H. Moghadasian, J.J. Frohlich, Effects of dietary phytosterols on choleaterol metabolism and atherosclerosis: clinical and experimental evidence, J. Am. Med. 107 (1999) 588.
6. W.L. Xu, Y.Q. Wang, P. Lu, Studies on the purification and recovery processes of phytosterols from deodorizer distillate, Chin. J. Process Eng. 2 (2002) 167.
7. W.L. Xu, Y.Q. Wang, Y.B. Huang, P. Lu, Studies on the selection of solvents for recrystallization purification phytosterol, J. Yangzhou Univ. 5 (2002) 58.
8. W.L. Xu, Y.B. Huang, J.H. Qian, J.F. Wu, Studies on the solubility of stigmasterol and ß-sitosterol in cyclohexanone and n-pentanol, J. Chem. Eng. Chin. Univ. 17 (2003) 707.
9. A. Poulos, J.W. Greiner, G.A. Fevig, Separation of sterols by countercurrent crystallization, Ind. Eng. Chem. 53 (1961) 949.
10. Koskenniska, Process for the isolation of bata-sitosterol, US Patent 4298539 (1981).
11. Hamunen, Process for the purification of beta-sitosterol isolated from the unsaponifiables in crude soap from the sulphate cellulose process, US Patent 4422974 (1983).
12. J.W. Lehman, Operational Organic Chemistry, vol. 62, Allyn and Bacon Inc., Boston, 1981, p. 394.
13. J.W. Mullin, Crystallization, third ed., Butterworth Heineman, Oxford, 1997 (Chapters 3, 4 and 7).
14. A. Mersman, Crystallization Technology Handbook, second ed., Marcel Dekker, New York, Basel, 2001 (Chapters 1-4).
15. J.H. Qian, W.L. Xu, Determination of the content of ß-sitosterol and stigmasterol in phytosterol by IR spectra method, Spectrosc. Spectral Anal. (China) 23 (2003) 692.
16. W.L. Xu, O. Sha, J.H. Qian, X.X. Zhang, Determination of the content of ß-sitosterol and stigmasterol in phytosterol by UV spectra method, Spectrosc. Spectral Anal. (China) 23 (2003) 933.