The role of fatty acid oxidation in cardiac ischemia and reperfusion

Advanced Studies in Medicine

Volumn 4, Issue 10 B, 2004, Pages

  Lopaschuk, Gary ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE; MALONYL COENZYME A; OXYGEN;

DISEASE EXACERBATION; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GLUCOSE OXIDATION; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HEART WORK; HOMEOSTASIS; HUMAN; MITOCHONDRIAL MEMBRANE; MUSCLE NECROSIS; NONHUMAN; REVIEW;

EID: 10644237915     PISSN: 15303004     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. Opie LH, Lopaschuk GD. Fuels: aerobic and anaerobic metabolism. In: Opie LH, ed. Heart Physiology from Cell to Circulation. 4th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2004:306-354.
2. Jafri MS, Dudycha SJ, O'Rourke B. Cardiac energy metabolism: models of cellular respiration. Annu Rev Biomed Eng. 2001;3:57-81.
3. Visser FC. Imaging of cardiac metabolism using radiola-belled glucose, fatty acids, and acetate. Coron Artery Dis. 2001;12(suppl 1):S12-S18.
4. Cruikshank EW, Kosterlitz HW. Utilization of fat by aglycaemic mammalian heart. J Physiol. 1941;99:208-223.
5. Bing RJ, Siegel A, Ungar I, Gilbert M. Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism. Am J Med. 1954;16(4):504-515.
6. Carvajal K, Moreno-Sánchez R. Heart metabolic disturbances in cardiovascular diseases. Arch Med Res. 2003; 34(2):89-99.
7. Balaban RS. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J Mol Cell Cardiol. 2002; 34(10):1259-1271.
8. Lopaschuk G. Regulation of carbohydrate metabolism in ischemia and reperfusion. Am Heart J. 2000;139(2, pt 3):S115-S119.
9. Lopaschuk GD. Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated? Coron Artery Dis. 2001;12(suppl 1):S8-S11.
10. Lopaschuk GD. Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism. Am J Cardiol. 1998;82(5A):14K-17K.
11. Lopaschuk GD, Collins-Nakai R, Olley PM, et al. Plasma fatty acid levels in infants and adults after myocardial ischemia. Am Heart J. 1994;128(1):61-67.
12. Mueller HS, Ayres SM. Metabolic response of the heart in acute myocardial infarction in man. Am J Cardiol. 1978; 42(3):363-371.
13. Wolff AA, Rotmensch HH, Stanley WC, Ferrari R. Metabolic approaches to the treatment of ischemic heart disease: the clinicians' perspective. Heart Fail Rev. 2002; 7(2):187-203.
14. Hopkins TA, Dyck JR, Lopaschuk GD. AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. Biochem Soc Trans. 2003;31(pt 1):207-212.
15. Sambandam N, Lopaschuk GD. AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart. Prog Lipid Res. 2003;42(3):238-256.
16. Liedtke AJ, Renstrom B, Nellis SH, Hall JL, Stanley WC. Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis. J Am Call Cardiol. 1995;26(3):815-825.
17. Liedtke AJ, Nellis SH, Mjos OD. Effects of reducing fatty acid metabolism on mechanical function in regionally ischemic hearts. Am J Physiol. 1984;247(3, pt 2):H387-H394.
18. Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1994;1213(3):263-276.
19. Stanley WC. Cardiac energetics during ischaemia and the rationale for metabolic interventions. Coron Artery Dis. 2001;12(suppl 1):S3-S7.
20. Das DK, Engelman RM, Rousou JA, Breyer RH. Aerobic vs anaerobic metabolism during ischemia in heart muscle. Ann Chir Gynaecol. 1987;76(1):68-76.
21. Renstrom B, Nellis SH, Liedtke AJ. Metabolic oxidation of pyruvate and lactate during early myocardial reperfusion. Circ Res. 1990;66(2):282-288.
22. Opie LH. The mechanism of myocyte death in ischemia. Eur Heart J. 1993;14(suppl G):31-33.
23. Opie LH, Sack MN. Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J Mol Cell Cardiol. 2002;34(9):1077-1089.
24. Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial dysfunction in cardiac disease: ischemia - reperfusion, aging, and heart failure. J Mol Cell Cardiol. 2001;33(6):1065-1089.
25. Wang QD, Pernow J, Sjoquist PO, Ryden L. Pharmacological possibilities for protection against myocardial reperfusion injury. Cardiovasc Res. 2002;55(1):25-37.
26. Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res. 1997;33(2):243-257.
27. Xie GH, Rah SY, Yi KS, et al. Increase of intracellular Ca (2+) during ischemia/reperfusion injury of heart is mediated by cyclic ADP-ribose. Biochem Biophys Res Commun. 2003;307(3):713-718.