Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis

Hepatology Research

Volumn 30, Issue 3, 2004, Pages 141-147

  Avni, Yona ^a   Shirin, Haim ^a   Aeed, Hussein ^a   Shahmurov, Mark ^a,b   Birkenfeld, Shlomo ^a   Bruck, Rafael ^a  

^a WOLFSON MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cytochrome P4502E1; Fatty liver; Fulminant hepatic failure; Thioacetamide

Indexed keywords

AMMONIA; CHOLINE; CYTOCHROME P450 2E1; LIPID; LIVER ENZYME; LIVER EXTRACT; MALONALDEHYDE; METHIONINE; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIETARY INTAKE; DISEASE MODEL; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG UTILIZATION; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIPID PEROXIDATION; LIVER INJURY; LIVER NECROSIS; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRITIONAL DEFICIENCY; OBESITY; PRIORITY JOURNAL; RAT; REMISSION; SURVIVAL RATE; WESTERN BLOTTING;

EID: 10644232975     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2004.08.004     Document Type: Article

References (51)

1. S. Sherlock Alcoholic liver disease Lancet 345 1995 227-229
2. C.P. Day S.J. Yeaman The biochemistry of alcoholic fatty liver Biochim Biophys Acta 1215 1994 33-48
3. C.S. Lieber Alcohol and the liver: 1994 update Gastroenterology 106 1994 1085-1105
4. B.R. Bacon M.J. Farahvash C.G. Janney B.A. Neuschwander-Tetri Nonalcoholic steatohepatitis: An expanded clinical entity Gastroenterology 107 1994 1103-1109
5. I.R. Wanless J.S. Lentz Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors Hepatology 12 1990 1106-1110
6. A.D. Burt R.N.M. MacSween T.J. Peters K.J. Simpson et al. Non-alcoholic fatty liver: Causes and complications 1st ed. In: N. McIntyre editor Oxford Textbook of Clinical Hepatology vol. 2 1991 Oxford University Press Oxford 865-871
7. A.M. Diehl Z. Goodman K.G. Ishak Alcohol-like disease in nonalcoholics Gastroenterology 95 1998 1056-1062
8. E.E. Powell W.G.E. Cooksley R. Hanson J. Searle J.W. Halliday L.W. Powell The natural history of nonalcoholic steatohepatitis: A follow up study of forty-two patients for up to 21 years Hepatology 11 1990 74-80
9. R.G. Lee Nonalcoholic steatohepatitis, a study of 49 patients Hum Pathol 20 1989 594-598
10. C.P. Day O.F.W. James Hepatic steatosis: Innocent bystander or guilty party? Hepatology 27 1998 1463-1466
11. M.R. Teli C.P. Day A.D. Burt M.K. Bennelt O.F.M. James Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver Lancet 346 1995 987-990
12. T. Takahashi J.M. Lasker A.S. Rosman C.S. Lieber Induction of cytochrome P4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA Hepatology 17 1993 236-245
13. M. Ingelman-Sundberg G. Ekstrom N. Tindberg Lipid peroxidation dependent on ethanol-inducible cytochrome P450 from rat liver Adv Biophys 71 1988 43-47
14. M. Ingelman-Sundberg I. Johansson H. Yin Y. Terelius E. Eliasson P. Clot E. Albano Ethanol-inducible cytochrome P4502E1: Genetic polymorphism regulation and possible role in the etiology of alcohol-induced liver disease Alcohol 10 1993 447-452
15. Y. Dai J. Rashba-Step A.L. Cederbaum Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and the production of reactive oxygen intermediates Biochemistry 32 1993 6928-6937
16. M.D. Weltman G.C. Farrell P. Hall M. Ingelman-Sundberg C. Liddle Hepatic cytochrome P4502E1 is increased in patients with nonalcoholic steatohepatitis Hepatology 27 1998 128-133
17. L.V. Favreau D.M. Malchoff J.E. Mole J.B. Schenkman Responses to insulin by two forms of rat hepatic microsomal cytochrome P450 that undergo major (RLM6) and minor (RLM56) elevations in diabetes J Biol Chem 262 1987 14319-14326
18. J.L. Raucy J.M. Lasker J.C. Kraner D.E. Salazar C.S. Lieber G.B. Corcoran Induction of cytochrome P4502E1 in the obese overfed rat Mol Pharmacol 39 1991 275-280
19. M.D. Weltman G.C. Farrell C. Liddle Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation Gastroenterology 111 1996 1645-1653
20. M.R. Teli O.F. James A.D. Burt M.K. Benett C.P. Day The natural history of nonalcoholic fatty liver Hepatology 22 1995 1714-1719
21. C.A. Matteoni Z.M. Younossi T. Gramlich N. Boparai Y.C. Liu A.J. McCullough Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity Gastroenterology 116 1999 1413-1419
22. C.P. Day O.F.W. James Steatohepatitis: A tale of two "hits";? Gastroenterology 114 1998 842-844
23. P. Letteron B. Fromenty B. Terris C. Degott D. Pessayre Acute and chronic hepatitic steatosis lead to in vitro lipid peroxidation in mice J Hepatol 24 1996 200-208
24. B. Fromenty A. Berson D. Pessayre Microvesicular steatosis and steatohepatitis: Role of mitochondrial dysfunction and lipid peroxidation J Hepatol 26 Suppl. 1 1997 13-22
25. C. Zimmermann P. Ferenci C. Pifl C. Yurdaydin J. Ebner H. Lassmann E. Roth H. Hortnagl Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: Characterization of an improved model and study of amino acid-ergic neurotransmission Hepatology 9 1989 595-601
26. F.S. Larsen G.M. Knudsen O.B. Paulson H. Vilstrup Cerebral blood flow autoregulation is absent in rats with thioacetamide-induced hepatic failure J Hepatol 21 1994 491-495
27. D. Geller An improved rat model of hepatic encephalopathy due to fulminant hepatic failure: The role of supportive therapy In: P.B. Soeters J.H.P. Wilson A.J. Meijer E. Holm (Eds.) Advances in Ammonia Metabolism and Hepatic Encephalopathy 1988 Elsevier Science Publishers Amsterdam p. 213-217
28. W.G. Niehaus J.R. Samuelsson E.D. Wills Lipid peroxide formation in microsomes Biochem J 113 1969 315-341
29. T. Yamakawa S.-I. Tanaka Y. Yamakawa Y. Kiuchi F. Isoda S. Kawamoto K. Sokuda et al. Augmented production of tumor necrosis factor - alpha in obese mice Immunol Immunopathol 75 1995 5-56
30. V. Paradis M. Kollinger M. Fabre A. Holstege T. Poynard P. Bedossa In situ detection of lipid peroxidation by products in chronic liver diseases Hepatology 26 1997 135-142
31. H.C. Pinto P. Felipe A. Baptista A. Fernandes E. Camilo F. Ramalho M.C. Moura Hepatic steatosis and lipid peroxidation in human chronic liver diseases [Abstract] Hepatology 24 1996 311A
32. Y. Hasumura R. Teschke C.S. Lieber Increased carbon tetrachloride hepatotoxicity and its metabolism, after chronic ethanol consumption Gastroentrology 66 1974 415-422
33. C.J. McClain J.P. Kromhout F.J. Peterson J.L. Holtzman Potentiation of acetaminophen hepatotoxicity by alcohol JAMA 244 1980 251-253
34. P.Y. Wang T. Kaneko Y. Wang A. Sato Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats Hepatology 29 1999 161-165
35. A.L. Buchman M.D. Dubin A.A. Moukarzel D.J. Jenden M. Roch K.M. Rice J. Gornbein M.E. Ament Choline deficiency: A cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation Hepatology 22 1995 1399-1403
36. E.J. Drenick J. Fisler D. Johnson Hepatic steatosis after intestinal bypass - prevention and reversal by metronidazole irrespective of protein-calorie malnutrition Gastroenterology 82 1982 535-548
37. E. Chieli G. Malvaldi Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide-S-oxide Toxicology 31 1984 41-52
38. W.R. Porter R.A. Neal Metabolism of thioacetamide and thioacetamide-S-oxide by rat liver microsomes Drug Metab Dispos 6 1978 379-388
39. T. Wang K. Shankar M.J.J. Ronis H.M. Mehendale Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1 Pharm Exp Ther 294 2000 473-479
40. K.R. Shashi A. Udayan M.M. Harihara Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats Drug Met Disp 29 2001 1088-1095
41. I.A. Leclercq G.C. Farrel J. Field D.R. Bell F.G. Gonzalez G.R. Robertson CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis J Clin Invest 105 2000 1067-1075
42. A.L. Hunter M.A. Holscher R.A. Neal Thioacetamide-induced hepatic necrosis. Involvement of the mixed-function oxidase enzyme system J Pharmacol Exp Ther 200 1977 439-448
43. S.C. Lu Z.Z. Huang H. Yang H. Tsukamoto Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the rat Toxicol Appl Pharmacol 159 3 1999 161-168
44. D. Muller M. Sommer M. Kretzschmar T. Zimmermann V.U. Buko O.J. Lukivskaya R. Dargel Lipid peroxidation in thioacetamide-induced macronodular rat liver cirrhosis Toxicology 65 1991 199-203
45. P. Rozental C. Biava H. Spencer H.J. Zimmerman Liver morphology and function tests in obesity and during total starvation Am J Dig Dis 12 1967 198-208
46. T. Andersen C. Gluud M.B. Franzmann P. Christoffersen Hepatic effects of dietary weight loss in morbidly obese subjects J Hepatol 12 1991 224-229
47. J.P. Capron J. Delamarre J.L. Dupas A. Braillon C. Degott C. Quenum Fasting in obesity: Another cause of liver injury with alcoholic hyaline? Dig Dis Sci 27 1982 265-268
48. E.J. Drenick F. Simmons J.F. Murphy Effect on hepatic morphology of treatment of obesity by fasting, reducing diets, and small bowel bypass N Engl J Med 282 1970 829-834
49. V. Biourge J.M. Groff C. Fisher D. Bee J.G. Morris Q.R. Rogers Nitrogen balance, plasma free amino acid concentrations and urinary orotic acid excretion during long-term fasting in cats J Nutr 124 1994 1094-1103
50. L.G. Lu M.D. Zeng J.Q. Li J. Hua J.G. Fan D.K. Qiu Study on the role of free fatty acids in proliferation of rat hepatic stellate cells(II) World J Gastroenterol 4 1998 500-502
51. F.H. Luyckx P.J. Lefebvre A.J. Scheen Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss Diabetes Metabol 26 2000 98-106