Production of highly homogeneous and structurally intact recombinant von Willebrand Factor multimers by furin-mediated propeptide removal in vitro

Biotechnology and Applied Biochemistry

Volumn 24, Issue 3, 1996, Pages 257-267

  Schlokat, Uwe ^a   Fischer, Bernhard E ^a   Herlitschka, Sabine ^a   Antoine, Gerhard ^a   Preininger, Alexandra ^a   Mohr, Gabriele ^a   Himmelspach, Michèle ^a   Kistner, Otfried ^a   Falkner, Falko G ^a   Dorner, Friedrich ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; VON WILLEBRAND FACTOR;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; OVARY CELL; RECOMBINANT DNA TECHNOLOGY; VON WILLEBRAND DISEASE;

ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; FURIN; HUMANS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SUBTILISINS; VON WILLEBRAND FACTOR;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 10544256184     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Ruggeri, Z.M. and Ware, J. (1993) FASEB J. 310, 308 316
2. Meyer, D. and Girma, J.P. (1993) Thromb. Haemostasis 70, 99 104
3. Rodeghiero, F., Castaman, G. and Dini, E. (1987) Blood 69, 454 459
4. Ginsburg, D. and Bowie, E.J.W. (1992) Blood 79 2507 2519
5. Castaman, G. and Rodeghiero, F. (1995) Drugs 50, 602 614
6. Foster, P.A. (1995) Thromb. Haemostasis 74, 1370 1378
7. Mannucci, P.M., Lattuada, A. and Ruggeri, Z.M. (1994) Blood 83, 3018 3027
8. Furlan, M., Robles, R., Affolter, D., Meyer, D., Baillod, P. and Lämmle, P. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7503 7507
9. Dent, J. A., Galbusera, M. and Ruggen, Z.M. (1991) J. Clin. Invest. 88, 774 782
10. Fischer, B., Mitterer, A., Schlokat, U., Den Bouwmeester, R. and Dorner, F. (1994) FEBS Lett. 351, 345 348
11. Fischer, B.L., Schlokat, U., Mitterer, A., Reiter, M., Mundt, W., Turecek, P.L., Schwarz, H.P. and Dorner, I. (1995) FEBS Lett. 375, 259 262
12. Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J, (1993) J. Biol. Chem. 267, 23435 23438
13. Vey, M., Schäfer, W., Berghöfer, S., Klenk, H.D., and Garten, W. (1994) J. Cell Biol. 127, 1829 1842
14. Molloy, S.S., Thomas, L., Van Slyke, J.K., Stenberg, P.E. and Thomas, G. (1994) EMBO J. 13, 18 33
15. Leduc, R., Molloy, S.S., Thorne, B.A. and Thomas, G. (1992) J. Biol. Chem. 267, 14304 14308
16. Bristol, J.A., Freedman, S.J., Furie, B.C. and Furie, B. (1994) Biochemistry 33, 14136 14143
17. Wasley, L.C., Rehemtulla, A., Bristol, J.A. and Kaufman, R.J. (1993) J. Biol. Chem. 268, 8458-8465
18. Rehemtulla, A. and Kaufman, R.J. (1992) Blood 79, 2349 2355
19. Rehemtulla, A., Dorner, A.J. and Kaufman, R.J. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 8235 8239
20. van de Ven, W.J.M., Voorberg, J., Fontijn, R., Pannekoek, H., Van den Ouweland, A.M.W., Van Duijnhoven, H.L.P., Roebroek, A.J.M. and Siezen, R.J. (1990) Mol. Biol. Rep. 14, 265 275
21. Wise, R.J., Barr, P.J., Wong, P.A., Kiefer, M.C., Brake, A.J. and Kaufman, R.J. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 9378 9382
22. Rehemtulla, A., Barr, P.J., Rhodes, C.J. and Kaufman, R.J. (1993) Biochemistry 32, 11586 11590
23. Kaufman, R.J., Wasley, L.C., Spiliotes, A.J., Gossels, S.D., Latt. S.A., Larsen, G.R. and Kay, R.M. (1985) Mol. Cell. Biol. 5, 1750 1759
24. Creemers, J.W.M. (1994) Ph.D. Thesis, University of Leuven
25. Takahashi, S., Hatsuzawa K., Watanabe, T., Murakami, K. and Nakayama, K. (1994) J. Biochem. (Tokyo) 116, 47 52
26. Stieneke-Gröber, A., Vey, M., Angliker, H., Shaw, E., Thomas, G., Roberts, C., Klenk, H.D. and Garten, W. (1992) EMBO J. 11, 2407 2414
27. Oda, K., Misumi, Y., Ikehara, Y., Brennan, S.O., Hatsuzawa, K. and Nakayama, K. (1992) Biochem. Biophys. Res. Commun. 189, 1353 1361
28. Bravo, D.A., Gleason, J.B., Sanchez, R.I., Roth, R.A. and Fuller, R.S. (1994) J. Biol. Chem. 269, 25830 25837
29. Molloy, S.S., Bresnahan, P.A., Kumpel, K., Leppla, L. and Thomas, G. (1992) J. Biol. Chem. 267, 16396 16402
30. Vidricaire, G., Denault, J.B. and Leduc, R. (1993) Biochem. Biophys. Res. Commun. 195, 1011 1018
31. Klimpel, K.R., Molloy, S.S., Thomas, G. and Leppla, S.H. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 10277 10281
32. MacGregor, G.R. and Caskey, C.T. (1989) Nucleic Acids Res. 17, 2365
33. Lee, F., Mulligan, R., Berg, P. and Ringold, G. (1981) Nature (London) 294, 228 232
34. Graham, F.L. and van der Eb. A.J. (1973) Virology 52, 456 467
35. Laemmli, U.K. (1970) Nature (London) 227, 680-685
36. van Duijnhoven, H.L.P., Creemers, J.W.M., Kranenborg, M.G.C., Timmer, F.D.J., Groeneveld, A., Van den Ouweland, A.M.W., Roebroek, A.J.M. and van de Ven, W.J.M (1992) Hybridoma 11, 71 86
37. Burnet, F.M. (1940) Aust. J. Exp. Biol. Med. Sci. 18, 353-360
38. Hirst, G.K. (1941) Science 94, 22 23
39. Urlaub, G. and Chasin, L.A. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 4216 4220
40. Hatsuzawa, K., Nagahama, M., Takahashi, S., Takada, K., Murakami, K. and Nakayama, K. (1992) J. Biol. Chem. 267, 16094 16099
41. Lazarowitz, S.G. and Choppin, P.W. (1975) Virology 68, 440-454
42. Klenk, H.D., Rott, R., Orlich, M. and Bloedorn, J. (1975) Virology 68, 426-439
43. Horimoto, T., Nakayama, K., Smeekens, S.P. and Kawaoka, Y. (1994) J. Virol. 68, 6074-6078
44. Morsy, J., Garten, W. and Rott, R. (1994) Virology 202, 988 99
45. Esmon, C.T. (1987) Science 235, 1348-1352
46. Boon, G.D. (1993) Toxicol. Pathol. 21, 170 179
47. Koppelman, S.J., Koedam, J.A., van Wijnen, M., Stern, D.M., Nawroth, P.P., Sixma, J.J. and Bouma, B.N. (1994) J. Lab. Clin. Med. 123, 585-593
48. Kaufman, R.J. (1992) Annu. Rev. Med. 43, 325-339