Further studies on the mechanism of the mineralocorticoid action of licorice in humans

Journal of Endocrinological Investigation

Volumn 19, Issue 9, 1996, Pages 624-629

  Armanini, D ^a   Lewicka, S ^b   Pratesi, C ^a   Scali, M ^a   Zennaro, M C ^a   Zovato, S ^a   Gottardo, C ^a   Simoncini, M ^a   Spigariol, A ^a   Zampollo, V ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

11 hydroxysteroid dehydrogenase; Activity; Licorice; Plasma mineralocorticoid; Pseudohyperaldosteronism; Tetrahydrocortisol; Tetrahydrocortisone; Urinary free cortisol

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; GLYCYRRHIZIC ACID; MINERALOCORTICOID; MINERALOCORTICOID RECEPTOR; TETRAHYDROCORTISOL; TETRAHYDROCORTISONE;

ADULT; ALDOSTERONE BLOOD LEVEL; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROLYTE BLOOD LEVEL; ELECTROLYTE URINE LEVEL; ENZYME ACTIVITY; GLYCYRRHIZA; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PLASMA RENIN ACTIVITY; POTASSIUM BLOOD LEVEL; PSEUDOHYPOALDOSTERONISM; URINE LEVEL;

EID: 10544255355     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03349029     Document Type: Article

References (23)

1. Molhuysen J.A., Gerbandy J., De Vries L.A., De Jong J.C., Lenetra J.B., Turner K.P., Borst J.C.G. A licorice extract with desoxycorticosterone like action. Lancet 1: 381, 1950.
2. Ulmann A., Menard J., Corvol P. Binding of glycyrrhetinic acid to kidney mineralocorticoid and glucocorticoid receptors. Endocrinology 97: 46, 1975.
3. Armanini D., Karbowiak I., Funder J.W. Affinity of licorice derivatives for mineralocorticoid and glucocorticoid receptors. Clin. Endocrinol. (Oxf). 19: 606, 1983.
4. Armanini D., Karbowiak I., Krozowski Z., Funder J.W., Adam W.R. The mechanism of mineralocorticoid action of carbenoxolone. Endocrinology 111: 1683, 1982.
5. Armanini D., Wehling M., Weber P.C. Mineralocorticoid effector mechanism of licorice derivatives in human mononuclear leukocytes. J. Endocrinol. Invest. 12: 303, 1989.
6. Aterden L.M. Studies with glycyrrhetinic acid. Inhibition on metabolism of steroids in vitro. Biochem. J. 9: 75, 1958.
7. Tamura Y., Nishikawa T., Yamada K., Yamamoto M., Kumagai A. Effect of glycyrrhetinic acid and its derivatives on 4-Sulpha and 5 β reductase in rat liver. Arzneimittelforschung 229: 47, 1979.
8. Latif S.A., Conca T.J., Morris D.J. The effect of the licorice derivative glycyrrhetinic acid,on hepatic 3 α- and 3 β-hydroxysteroid dehydrogenase and 5 α and 5 β-reductase pathways of metabolism of aldosterone in male rats Steroids 55: 52, 1990.
9. Stewart P.M., Wallace A.M., Valentino R., Burt D., Shackleton C.H., Edward C.R.W. Mineralocorticoid activity of licorice 11β hydroxysteroid dehydrogenase deficiency comes of age. Lancet 1: 82, 1987.
10. Farese R.W., Biglieri E.G., Shackleton C.H.L., Irony I., Gomez-Fontes R. Licorice-induced hypermineralocorticism. N. Engl. J. Med. 325: 1223, 1991.
11. Funder J.W., Pearce P.T., Smith R., Smith A. Mineralocorticoid action: target tissue specificity is enzyme, not receptor mediated. Science 242: 583, 1988.
12. Edwards C.R.W., Stewart P.M., Burt D., Brett L., Mc Intyre L., Sutanto W.S., de Kloet E.R., Monder C. Localization of 11β hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptors. Lancet 2: 986, 1988.
13. Wilson R.C., Harbison M.D., Krozowski Z.S., Funder J.W., Shackleton C.H., Hanauske-Abel H.M., Wei J.Q., Hertecan J., Moran A., Neiberger R.E., Balfe J.W., Fattah A., Daneman D., Licholai T., New M. Several homozigous mutations in the gene for 11β-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess. J. Clin. Endocrinol. Metab. 80: 3145, 1995.
14. Bernardi M., D'Intino P., Trevisani F., Cantelli-Forti G.I., Raggi M.A., Turchetto E., Gasbarrini G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Life Science 55: 863, 1994.
15. Lan N.C., Matulich D.T., Stockigt J.R., Biglieri E.G., New M., Winter J.S.D., Mc Kenzie J.K., Baxter J.D. Radioreceptor assay of plasma mineralocorticoid activity. Circ. Res, 46 (suppl 1): 94, 1976.
16. Armanini D., Strasser T., Weber P.C. Characterization of aldosterone binding sites in human mononuclear leukocytes. Am. J. Physiol. 248: E388, 1985.
17. Ventura P., Visconti M., Pifferi G. A simple GLC. Analysis of ammonium glycyrrhizinate. Bollettino Chimico Farmaceutico 117: 217, 1978.
18. De Groot G., Koops R., Hogendorn E.A., Goewie C.E., Savelkoul T.J., Van Vloten P. Improvement of selectivity and sensitivity by column switching in the determination of glycyrrhizin and glycyrrhetinic acid in human plasma by high performance liquid chromatography. J. Chromatog. 456: 71, 1988.
19. Monder C., Shackleton C.H.L., Bradlow L., New M., Stoner E., Iohan F., Lakshmi V. The syndrome of apparent mineralocorticoid excess: its association with 11-β-hydroxysteroid-dehydrogenase and 5-β-reductase deficiency and some consequence for corticosteroid metabolism. J. Clin. Endocrinol. Metab. 63: 550, 1986.
20. Soro A., Ingram M.C., Tonolo G., Glorioso N., Fraser R. Evidence of coexisting changes in 11 hydroxysteroid dehydrogenase and 5-β-reductase activity in subjects with untreated essential hypertension. Hypertension 25: 67, 1995.
21. Armanini D., Witzgall H., Wehlig M., Kuhnle U., Weber P.C. Aldosterone receptors in different types of primary hyperaldosteronism. J. Clin. Endocrinol. Metab. 5: 101, 1987.
22. Armanini D., Zennaro M.C., Martella L., Pratesi C., Scali M., Zampollo V. Regulation of aldosterone receptors in hypertension. Steroids 58: 611, 1993.
23. Monder C., Shackleton C.H.L. 11-β-hydroxysteroid- dehydrogenase fact or fancy? Steroids 44: 383, 1986.