Phase I study of chemotherapy with carboplatin, epirubicin, and escalating dose of VP-16 with G-CSF support in extensive small cell lung cancer

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 19, Issue 6, 1996, Pages 589-591

  Gridelli, Cesare ^a,b   D'Aprile, Modesto ^a   Palmeri, Sergio ^a   Curcio, Carlo ^a   Rossi, Antonio ^a   Gebbia, Vittorio ^a   Veltri, Enzo ^a   Pepe, Rosario ^a   Pistillucci, Giorgio ^a   Bianco, Angelo Raffaele ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Chemotherapy; Small cell lung cancer; VP 16

Indexed keywords

CARBOPLATIN; EPIRUBICIN; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; BLOOD CELL COUNT; BONE MARROW TOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG SMALL CELL CANCER; MALE; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA;

ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW; CARBOPLATIN; CARCINOMA, SMALL CELL; CAUSE OF DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EPIRUBICIN; ETOPOSIDE; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEUTROPENIA; SEPSIS; THROMBOCYTOPENIA;

EID: 10544255341     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-199612000-00012     Document Type: Article

References (12)

1. Frei III E, Canellos GP. Dose: a critical factor in cancer chemotherapy. Am J Med 1980;69:585-94.
2. Fukuoka M, Masuda N, Takada M, Kodaura N, Kawahara M, Furuse K. Dose-intensity chemotherapy in extensive stage small cell lung cancer. Semin Oncol 1994;21:43-7.
3. Miles DW, Fogarty O, Ash CM, et al. Received dose-intensity: a randomized trial of weekly chemotherapy with and without granulocyte colony-stimulating factor in small cell lung cancer. J Clin Oncol 1994;12:77-82.
4. Gridelli C, D'Aprile M, Curcio C, et al. Carboplatin plus epirubicin plus VP-16, concurrent "split course" radiation therapy and adjuvant surgery for limited small cell lung cancer. Lung Cancer 1994;11:83-91.
5. Gridelli C, Ianniello GP, Maiorino A, et al. Carboplatin, epirubicin and VP-16 chemotherapy in the treatment of small cell lung cancer. Am J Clin Oncol 1994;17:160-2.
6. Johnson DH, Wolf SN, Hainsworth JD, et al. Extensive stage small cell bronchogenic carcinoma: intensive induction chemotherapy with high dose cyclophosphamide plus high dose etoposide. J Clin Oncol 1985;3:170-5.
7. Johnson DH, Hande KR, Porter LL, Hainsworth JD, Wolff SN, Greco FA. High-dose pilot studies in extensive stage small cell lung cancer. Semin Oncol 1986;13(suppl 3):37-9.
8. Murray N, Sham A, Osoba B, et al. Intensive weekly chemotherapy for the treatment of extensive stage small cell lung cancer. J Clin Oncol 1991;9:1632-8.
9. Humblet Y, Symann M, Bosly A. Late intensification chemotherapy with autologous bone marrow transplantation in selected small cell carcinoma of the lung: a randomized study. J Clin Oncol 1987;5:1864-73.
10. Bronchud MH, Scarffe JM, Thatcher N, et al. Phase I-II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 1987;56:809-13.
11. Crawford J, Ozer H, Stoller R, et al. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small cell lung cancer. N Engl J Med 1991;325:164-70.
12. Trillet-Lenoir V, Green J, Manegold C, et al. Recombinant granulocyte-colony stimulating factor reduces the infections complications of cytotoxic chemotherapy. Eur J Cancer 1993;29:319-24.